Expression and clinical implication of cyclooxygenase-2 and E-cadherin in oral squamous cell carcinomas

Santoro, Angela; Bufo, Pantaleo; Russo, Giuseppe; Cagiano, Simona; Papagerakis, Silvana; Bucci, Paolo; Aquino, Gabriella; Longo, Francesco; Feola, Antonia; Giordano, Antonio; Carlo, Angelina Di; Domenico, Marina Di; Pannone, Giuseppe

doi:10.1080/15384047.2015.1071741

Cited by 18 publications

(16 citation statements)

References 54 publications

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“…Many proinflammatory mediators play a critical role in the suppression of apoptosis, proliferation, angiogenesis, invasion, and metastasis, including TNF superfamily, interleukins, chemokines, MMP-9, VEGF, COX-2 and 5-LOX [35][36][37].…”

Section: Action Of Phlogistic Mediators In Cancer Developmentmentioning

confidence: 99%

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Contaldo

Boccellino

Zannini

et al. 2020

Journal of Oncology

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Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via genetic and epigenetic factors.

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Section: Action Of Phlogistic Mediators In Cancer Developmentmentioning

confidence: 99%

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Contaldo

Boccellino

Zannini

et al. 2020

Journal of Oncology

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“…Anesthesia and analgesia may affect EMT [ 25 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Studies have reported that propofol suppressed EMT in esophageal cancer, choriocarcinoma, breast cancer, thyroid cancer, lung cancer, gastric cancer, hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), prostate cancer, and oral squamous cell carcinoma cells [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ].…”

Section: Tumor Factors: Emt Hypoxia-inducible Factor-1α (Hif-1α) Matr...mentioning

confidence: 99%

Pancreatic Cancer and Microenvironments: Implications of Anesthesia

Lai

Kuo

Huang

et al. 2022

Cancers

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Pancreatic malignancy is a lethal neoplasm, as well as one of the leading causes of cancer-associated mortality, having a 5-year overall survival rate of less than 10%. The average life expectancy of patients with advanced pancreatic cancer does not exceed six months. Although surgical excision is a favorable modality for long-term survival of pancreatic neoplasm, metastasis is initially identified in nearly 80% of the patients by the time of diagnosis, making the development of therapeutic policy for pancreatic cancer extremely daunting. Emerging evidence shows that pancreatic neoplastic cells interact intimately with a complicated microenvironment that can foster drug resistance, metastasis, or relapse in pancreatic cancer. As a result, the necessity of gaining further insight should be focused on the pancreatic microenvironment contributing to cancer progression. Numerous evidence reveals that perioperative factors, including surgical manipulation and anesthetics (e.g., propofol, volatile anesthetics, local anesthetics, epidural anesthesia/analgesia, midazolam), analgesics (e.g., opioids, non-steroidal anti-inflammatory drugs, tramadol), and anesthetic adjuvants (such as ketamine and dexmedetomidine), might alter the tumor microenvironment and cancer progression by affecting perioperative inflammatory or immune responses during cancer surgery. Therefore, the anesthesiologist plays an important role in perioperative management and may affect surgical outcomes. However, the literature on the impact of anesthesia on the pancreatic cancer microenvironment and progression is limited. This review summarizes the current knowledge of the implications of anesthesia in the pancreatic microenvironment and provides future anesthetic strategies for improving pancreatic cancer survival rates.

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“…COX-2 decreases the expression of E-cadherin and leads to phenotypic changes in epithelial cells enhancing their carcinogenic potential. This study was performed by a tissue microarray of oral squamous cell carcinomas from human patients [102].…”

Section: Prostaglandins In Other Cancermentioning

confidence: 99%

The Role of Prostaglandins in Different Types of Cancer

Jara-Gutiérrez

Baladrón

2021

Cells

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The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have been linked to inflammation, female reproductive cycle, vasodilation, or bronchodilator/bronchoconstriction. Recent studies have highlighted the involvement of these lipids in cancer. In this review, existing information on the prostaglandins associated with different types of cancer and the advances related to the potential use of them in neoplasm therapies have been analyzed. We can conclude that the effect of prostaglandins depends on multiple factors, such as the target tissue, their plasma concentration, and the prostaglandin subtype, among others. Prostaglandin D2 (PGD2) seems to hinder tumor progression, while prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2α) seem to provide greater tumor progression and aggressiveness. However, more studies are needed to determine the role of prostaglandin I2 (PGI2) and prostaglandin J2 (PGJ2) in cancer due to the conflicting data obtained. On the other hand, the use of different NSAIDs (non-steroidal anti-inflammatory drugs), especially those selective of COX-2 (cyclooxygenase 2), could have a crucial role in the fight against different neoplasms, either as prophylaxis or as an adjuvant treatment. In addition, multiple targets, related to the action of prostaglandins on the intracellular signaling pathways that are involved in cancer, have been discovered. Thus, in depth research about the prostaglandins involved in different cancer and the different targets modulated by them, as well as their role in the tumor microenvironment and the immune response, is necessary to obtain better therapeutic tools to fight cancer.

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Expression and clinical implication of cyclooxygenase-2 and E-cadherin in oral squamous cell carcinomas

Cited by 18 publications

References 54 publications

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Pancreatic Cancer and Microenvironments: Implications of Anesthesia

The Role of Prostaglandins in Different Types of Cancer

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