Expression and characterization of a novel recombinant cytotoxin II from Naja naja oxiana venom: A potential treatment for breast cancer

Derakhshani, Afshin; Silvestris, Nicola; Hajiasgharzadeh, Khalil; Mahmoudzadeh, Sara; Fereidouni, Mohammad; Paradiso, Angelo; Brunetti, Oronzo; Atarod, Deyhim; Safarpour, Hossein; Baradaran, Behzad

doi:10.1016/j.ijbiomac.2020.06.130

Cited by 9 publications

(3 citation statements)

References 35 publications

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“…The extrinsic pathway involves activation of caspase 8 and caspase 3. Some 3FTx (e.g., rCT3) can induce both intrinsic and extrinsic apoptotic pathways as demonstrated by PLA2 and LAAO toxins (Derakhshani et al, 2020). Another toxin, DIS, interacts with integrins and disrupts cancer cells adhesion, invasion, migration, angiogenesis and actin cytoskeletal reorganisation by inhibiting several pathways through focal adhesion kinases (FAK) (Kolvekar et al, 2023).…”

Section: Other Snake Venom Toxins Anticancer Activitiesmentioning

confidence: 99%

“…CT2 had a minimal effect against the normal MCF10A cell lines with IC 50 18.12 ± 2.56 μg/ml. On the other hand, the recombinant cytotoxin 3 (rCT3) (IC 50 3.66 μg/ml) from the same snake showed anti‐proliferative and enhanced apoptosis through the intrinsic and extrinsic pathways in MCF‐7 cells (Derakhshani et al, 2020).…”

Section: Anticancer Effects Of Individual Snake Venom Toxinsmentioning

confidence: 99%

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Snake venom toxins: Potential anticancer therapeutics

Offor,

Piater

2023

J of Applied Toxicology

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Snake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment of these diseases. In this regard, Captopril used in the treatment of cardiovascular diseases was the first animal venom toxin‐based drug approved by the US Food and Drug Administration and the European Medicines Agency. Cancers cause morbidity and mortality worldwide. Due to side effects associated with the current cancer treatments including chemotherapy, radiotherapy, immunotherapy, hormonal therapy and surgery, there is a need to improve the efficacy of current treatments and/or develop novel drugs from natural sources including animal toxin‐based drugs. There is a long history of earlier and ongoing studies implicating snake venom toxins as potential anticancer therapies. Here, we review the role of crude snake venoms and toxins including phospholipase A2, L‐amino acid oxidase, C‐type lectin and disintegrin as potential anticancer agents tested in cancer cell lines and animal tumour models in comparison to normal cell lines. Some of the anti‐tumour activities of snake venom toxins include induction of cytotoxicity, apoptosis, cell cycle arrest and inhibition of metastasis, angiogenesis and tumour growth. We thus propose the advancement of multidisciplinary approaches to more pre‐clinical and clinical studies for enhanced bioavailability and targeted delivery of snake venom toxin‐based anticancer drugs.

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Section: Other Snake Venom Toxins Anticancer Activitiesmentioning

confidence: 99%

Section: Anticancer Effects Of Individual Snake Venom Toxinsmentioning

confidence: 99%

Snake venom toxins: Potential anticancer therapeutics

Offor,

Piater

2023

J of Applied Toxicology

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“…Additionally, macrovipecetin, a C-type lectin from Macrovipera lebetina, suppressed the migration, invasion and proliferation of the human melanoma cell line SK-MEL-28 [94]. Crotoxin, a toxin derived from Crotalus durissus terrificus and cytotoxin 2 derived from Naja naja oxiana decreased the viability of MCF7aro cells via the inhibition of the extracellular signal-regulated kinase (ERK) pathway, inhibited cell migration by inducing the apoptosis of MCF7 cells, and showed an anticancer effect on lung cancer cells in A549 cells through the activation of the caspase-3 and p38 pathways [95][96][97]. Daboialectin, a C-type lectin derived from Daboia russelii, effectively inhibited cell motility by promoting the cytoskeletal damage and apoptosis of A549 cells [98].…”

Section: Venommentioning

confidence: 99%

Reptiles as Promising Sources of Medicinal Natural Products for Cancer Therapeutic Drugs

2022

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Natural products have historically played an important role as a source of therapeutic drugs for various diseases, and the development of medicinal natural products is still a field with high potential. Although diverse drugs have been developed for incurable diseases for several decades, discovering safe and efficient anticancer drugs remains a formidable challenge. Reptiles, as one source of Asian traditional medicines, are known to possess anticancer properties and have been used for a long time without a clarified scientific background. Recently, it has been reported that extracts, crude peptides, sera, and venom isolated from reptiles could effectively inhibit the survival and proliferation of various cancer cells. In this article, we summarize recent studies applying ingredients derived from reptiles in cancer therapy and discuss the difficulties and prospective development of natural product research.

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