Expression Analysis of Several Lymphoma-specific Genes in Human Fibroblasts Immortalized with SV40

Nenasheva, Valentina V.; Николаев, А. И.; Dubovaya, V. I.; Иноземцева, Л. С.; Manuilova, Ekaterina; Martynenko, A. V.; Tarantul, V. Z.

doi:10.1023/b:mbil.0000023738.02092.ab

Cited by 2 publications

(3 citation statements)

References 35 publications

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“…These changes evolve over the lifecycle of the malignant cell and its milieu. Indeed, low grade gliomas show evidence of mtDNA increases, which was also noted by Nenasheva et al (24) in other haematologic neoplasms. In contrast, varying results have been reported in hepatocellular, lung, colorectal and gastric cancers, where some, but not all, types showed an amplification of mtDNA (141,151).…”

Section: Discussionsupporting

confidence: 77%

“…Jia et al (21) showed increases in mtDNA levels with the mdr-1 genotype, and Tarantul et al (22) found evidence for amplified mitochondrial sequences in SIVinfected primate non-Hodgkin lymphoma (NHL). Similarly, Nikolaev et al (23) showed mtDNA increases in simian NHL, and Nenasheva et al (24) found that such sequences increased in SV40-transformed fibroblasts, observations suggesting that such modifications serve as early markers for the development and/or the pathogenesis of malignancy. However, Dani et al (25) evaluated breast, colorectal, gastric and head and neck tumours for the mtDNA 4977 deletion ('common deletion'), and concluded that cells of these tumour types are essentially free of this mutation; similarly, Kiebish and Seyfried (26) did not find significant mtDNA mutations in mouse brain tumours and concluded that these mutations do not play a role in either chemically-induced or spontaneous mouse brain tumours.…”

Section: Alterations Of Mitochondrial Dnamentioning

confidence: 90%

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The importance of mitochondria in the tumourigenic phenotype: Gliomas as the paradigm (Review)

Liang¹

2011

Int J Mol Med

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Abstract. Cancer arises from the accumulation of nuclear and cytoplasmic abnormalities, a phenomenon allowing for the expression of the tumourigenic phenotype. Gliomas represent the most frequently diagnosed tumours of the central nervous system in adults. Warburg hypothesized the importance of glycolysis in cancer cells, and implicated additional roles of mitochondria in neoplasia. Recent data have shown the importance of mitochondria in the tumourigenic phenotype, in particular, within the apoptotic process. There have been a variety of studies conducted on brain tumours revealing significant alterations of mitochondria within the tumourigenic phenotype. This review describes some of the more recent findings of mitochondria and gliomas, correlating findings to those observed in other cancers. Alterations in mitochondrial DNA copy number and location, as well as dependence of the cancer cell phenotype on mitochondria are emphasised. In addition to its role in apoptosis, the mitochondrion serves as an important element in the tumourigenic phenotype, and clinical approaches targeting this organelle have potential for the development of effective treatment regimens for patients with glioma and other neoplastic diseases.

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Section: Discussionsupporting

confidence: 77%

Section: Alterations Of Mitochondrial Dnamentioning

confidence: 90%

The importance of mitochondria in the tumourigenic phenotype: Gliomas as the paradigm (Review)

Liang¹

2011

Int J Mol Med

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“…It is difficult to discriminate whether this phenomenon is a cause or a consequence of oncogenesis. But our experiments with immortalized fibroblasts, used as a model of early stage of oncogenesis, suggest that enhanced transcription of mitochondrial genes can be associated with the early stages of oncogenesis 34 .…”

Section: Discussionmentioning

confidence: 79%

Differential gene expression in HIV/SIV-associated and spontaneous lymphomas

Nenasheva¹,

Николаев²,

Martynenko³

et al. 2005

Int. J. Med. Sci.

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Diffuse large B-cell lymphoma (DLBCL) is more prevalent and more often fatal in HIV-infected patients and SIV-infected monkeys compared to immune-competent individuals. Molecular, biological, and immunological data indicate that virus-associated lymphomagenesis is similar in both infected hosts. To find genes specifically overexpressed in HIV/SIV-associated and non-HIV/SIV-associated DLBCL we compared gene expression profiles of HIV/SIV-related and non-HIV-related lymphomas using subtractive hybridization and Northern blot analysis. Our experimental approach allowed us to detect two genes (a-myb and pub) upregulated solely in HIV/SIV-associated DLBCLs potentially involved in virus-specific lymphomagenesis in human and monkey. Downregulation of the pub gene was observed in all non-HIV-associated lymphomas investigated. In addition, we have found genes upregulated in both non-HIV- and HIV-associated lymphomas. Among those were genes both with known (set, ND4, SMG-1) and unknown functions. In summary, we have demonstrated that simultaneous transcriptional upregulation of at least two genes (a-myb and pub) was specific for AIDS-associated lymphomas.

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Expression Analysis of Several Lymphoma-specific Genes in Human Fibroblasts Immortalized with SV40

Cited by 2 publications

References 35 publications

The importance of mitochondria in the tumourigenic phenotype: Gliomas as the paradigm (Review)

The importance of mitochondria in the tumourigenic phenotype: Gliomas as the paradigm (Review)

Differential gene expression in HIV/SIV-associated and spontaneous lymphomas

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