Expression alteration and dysfunction of ion channels/transporters in the parietal cells induces gastric diffused mucosal injury

Zhao, Yingying; Deng, Zilin; Ma, Zhiyuan; Zhang, Minglin; Wang, Hu; Tuo, Biguang; Li, Taolang; Liu, Xuemei

doi:10.1016/j.biopha.2022.112660

Cited by 2 publications

(2 citation statements)

References 89 publications

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“…Low Aqp4 expression may represent a good biomarker for spasmolytic polypeptideexpressing metaplasia (SPEM) (a regenerative lesion of the gastric mucosa that can evolve towards cancer). The lowered gastrin levels in SPEM [139,140] may account for the decreased Aqp4 expression as gastrin can regulate Aqp4 expression [141].…”

Section: Pathophysiological Involvement Of Aqps In Gastric Diseasesmentioning

confidence: 99%

Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Calamita,

Delporte

2023

Cells

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Aquaporins (AQPs), transmembrane proteins permeable to water, are involved in gastrointestinal secretion. The secretory products of the glands are delivered either to some organ cavities for exocrine glands or to the bloodstream for endocrine glands. The main secretory glands being part of the gastrointestinal system are salivary glands, gastric glands, duodenal Brunner’s gland, liver, bile ducts, gallbladder, intestinal goblet cells, exocrine and endocrine pancreas. Due to their expression in gastrointestinal exocrine and endocrine glands, AQPs fulfill important roles in the secretion of various fluids involved in food handling. This review summarizes the contribution of AQPs in physiological and pathophysiological stages related to gastrointestinal secretion.

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Section: Pathophysiological Involvement Of Aqps In Gastric Diseasesmentioning

confidence: 99%

Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Calamita,

Delporte

2023

Cells

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“…And the damaging agents that accompany with GMBF can reach the lamina propria, causing gastric hydrochloric acid-related disorders mediated by parietal cells that penetrate into the interior of the lamina propria. As a result, GMI is deeply exacerbated by counter diffusing hydrochloric acid and diffuse injury occurs ( Zhao, et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury

Jia,

He,

et al. 2023

Front. Pharmacol.

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Introduction: The gastric mucosa (GM) is the first barrier and vital interface in the stomach that protects the host from hydrochloric acid in gastric juice and defends against exogenous insults to gastric tissues. The use of traditional Chinese medications (TCMs) for the treatment of gastric mucosal injury (GMI) has long-standing history and a good curative effect. Whereas there are poor overall reports on the intrinsic mechanisms of these TCM preparations that pharmacology uses to protect body from GMI, which is crucial to treating this disease. These existing reviews have deficiencies that limit the clinical application and development of both customary prescriptions and new drugs.Methods: Further basic and translational studies must be done to elucidate the intrinsic mechanisms of influence of these TCM preparations. Moreover, well-designed and well-conducted experiences and clinical trials are necessary to ascertain the efficacy and mechanisms of these agents. Therefore, this paper presents a focused overview of currently published literature to assess how TCMs action that facilitates the cures for GMI. It offers a whole train of current state of pharmacological evidence, identifies the pharmacological mechanisms of TCMs on GM, and highlights that remarkable capacity of TCMs to restore GM after damage.Results: These TCMs preparations promote the repair of multicomponent targets such as the gastric mucus, epithelial layer, blood flow (GMBF) and lamina propria barrier.Summary: Overall, this study has summarized the essential regulatory mechanisms and pharmacological efficacy of TCMs on new and productive therapeutic targets.Discussion: This review provides an avenue for studying various drugs with potentially promising effects on mucosal integrity, as well as subsequent pharmacological studies, clinical applications, and new drug development.

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Expression alteration and dysfunction of ion channels/transporters in the parietal cells induces gastric diffused mucosal injury

Cited by 2 publications

References 89 publications

Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury

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