Expressing Optogenetic Actuators Fused to N‐terminal Mucin Motifs Delivers Targets to Specific Subcellular Compartments in Polarized Cells
Jiali Wang,
Eric Platz‐Baudin,
Erik Noetzel
et al.
Abstract:Optogenetics is a powerful approach in neuroscience research. However, other tissues of the body may benefit from controlled ion currents and neuroscience may benefit from more precise optogenetic expression. The present work constructs three subcellularly‐targeted optogenetic actuators based on the channelrhodopsin ChR2‐XXL, utilizing 5, 10, or 15 tandem repeats (TR) from mucin as N‐terminal targeting motifs and evaluates expression in several polarized and non‐polarized cell types. The modified channelrhodop… Show more
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