This study examines whether the sociocultural context moderates the relationship between families' expressed emotion and clinical outcomes in schizophrenia. In a sample of 60 Mexican-American caregivers and their ill relatives, we first assessed whether expressed emotion (EE), and its indices (criticism, EOI and warmth), relate to relapse. Secondly, we extended the analysis of EE and its indices to a longitudinal assessment of symptomatology. Last, we tested whether bidimensional acculturation moderates the relationship between EE (and its indices) and both relapse and symptom trajectory over time. Results indicated that EOI was associated with increased relapse and that criticism was associated with increased symptomatology. Additionally as patients' Mexican enculturation (Spanish language and media involvement) decreased, EE was increasingly related to relapse. For symptomatology, as the patient's U.S. acculturation (English language and media involvement) increased, EE was associated with increased symptoms longitudinally. Our results replicate and extend past research on how culture might shape the way family factors relate to the course of schizophrenia.