Expresión de la osteocalcina en el ligamento periodontal al inducir fuerzas ortodóncicas

Brito, Maritere Villarreal; Pérez, Mario Arturo Ortíz; Rodríguez, Francisco Javier Marichi

doi:10.1016/s1870-199x(13)72030-5

Cited by 1 publication

(1 citation statement)

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“…Periostin can directly bind to collagen type I, enhancing the collagen fibrillogenesis and therefore the mechanical properties of connective tissues ( 43 ). OCN is the most abundant non-collagenous protein expressed in periodontal tissues, and it may serve as a biological index reflecting the activity of osteoblasts during bone formation ( 44 , 45 ). Moreover, since the development of vasculature is essential for osteogenesis to take place, expression of an angiogenic marker vWF, which is routinely used for identification of blood vessel formation ( 46 , 47 ), was analysed.…”

Section: Discussionmentioning

confidence: 99%

Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament

Yang

Pullisaar

Stunes

et al. 2023

European Journal of Orthodontics

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Summary Objectives Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in vivo. Materials and methods The maxillary right first molars of male Wistar rats (n = 21) were moved mesially for 14 days, with submucosal injection of two dosages of irisin (0.1 or 1 μg) or phosphate-buffered saline (control) every third day. OTM was recorded by feeler gauge and micro-computed tomography (μCT). Alveolar bone and root volume were analysed using μCT, and plasma irisin levels by ELISA. Histological characteristics of PDL tissues were examined, and the expression of collagen type I, periostin, osteocalcin (OCN), von Willebrand factor (vWF) and fibronectin type III domain-containing protein 5 (FNDC5) in PDL was evaluated by immunofluorescence staining. Results Repeated 1 μg irisin injections suppressed OTM on days 6, 9, and 12. No significant differences were observed in OTM in the 0.1 μg irisin group, or in bone morphometric parameters, root volume or plasma irisin, compared to control. Resorption lacunae and hyalinization were found at the PDL-bone interface on the compression side in the control, whereas they were scarce after irisin administration. The expression of collagen type I, periostin, OCN, vWF, and FNDC5 in PDL was enhanced by irisin administration. Limitations The feeler gauge method may overestimate OTM. Conclusions Submucosal irisin injection reduced OTM by enhancing osteogenic potential of PDL, and this effect was more significant on the compression side.

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