Exposures to IARC Carcinogenic Agents in Work Settings Not Traditionally Associated with Sinonasal Cancer Risk: The Experience of the Italian National Sinonasal Cancer Registry

Binazzi, Alessandra; Mensi, Carolina; Miligi, Lucia; Marzio, Davide Di; Zajacovà, Jana; Galli, Paolo; Camagni, Angela; Calisti, Roberto; Balestri, Anna; Murano, Stefano; Piro, Sara; d’Errico, Angelo; Bonzini, Matteo; Massacesi, Stefania; Sorasio, Denise; Marinaccio, Alessandro; Working, on behalf of ReNaTuNS

doi:10.3390/ijerph182312593

Cited by 5 publications

(2 citation statements)

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“…The most frequent agents were wood and leather dust. This result was also confirmed in a subsequent study of the Italian SNC Registry exploring jobs where an association with such carcinogens is unusual [ 22 ].…”

Section: Discussionsupporting

confidence: 66%

Sinonasal cancer incidence in Lombardy, Italy, 2008–20

Consonni,

Stoppa,

Binazzi

et al. 2024

Occupational Medicine

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Background Epithelial sinonasal cancers (SNC) are rare tumours with recognized associations with known/suspected occupational carcinogens (wood/leather dust, nickel/chromium compounds and formaldehyde). In Italy, a national SNC registry organized as a network of regional registries was established by law in 2008. Aims To describe SNC time trends, occupational exposures and geographical distribution in Lombardy, North-West Italy, based on population registry data (2008–20). Methods The Lombardy SNC Registry records epithelial SNCs using various sources. Interviews to collect occupational history are performed using a standardized questionnaire. Using several standard populations, we calculated yearly crude and age-standardized rates (ASRs per 100,000 person-years). Standardized incidence ratios (SIR) at municipality level were calculated, and Bayesian models were fitted to produce smoothed SIR maps. Results We recorded 827 cases (553 men, 274 women). Crude (world standardized) ASRs were 0.9 (0.4) in men and 0.4 (0.2) in women, with no time trends. Interviews were obtained for 485 (88%) men and 223 (81%) women. Among men, 217 (45%) had been exposed to occupational carcinogens (wood/leather dust: 150/65 cases, 31%/13%), while only 36 women (16%) were exposed. Among 201 men with adenocarcinoma, exposure to wood/leather dust occurred in 103/50 cases (75%/50%). Areas with elevated SIRs associated with leather dust were found in the Western areas. Exposure to wood dust was more widespread. Conclusions This study found a high frequency of occupational exposures (wood and leather dust), particularly in men with SNC. Employment in shoe industries clustered in the Western part, while work in furniture industries was less spatially structured.

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Section: Discussionsupporting

confidence: 66%

Sinonasal cancer incidence in Lombardy, Italy, 2008–20

Consonni,

Stoppa,

Binazzi

et al. 2024

Occupational Medicine

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“…Due to the strong association of SNCs with exposure to occupational carcinogens, in Italy a specific nationwide population-based epidemiological surveillance system of SNC cases was implemented (law 81/2008) through a national SNC cancer registry (ReNaTuNS: Registro Nazionale Tumori Naso-Sinusali) [ 7 , 13 ]. The reporting of SNC cases to the national SNC registry is compulsory.…”

Section: Introductionmentioning

confidence: 99%

Survival of Patients with Sinonasal Cancers in a Population-Based Registry, Lombardy, Italy, 2008–2023

Consonni,

Stella,

Denaro

et al. 2024

Cancers

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Sinonasal cancers (SNCs) are rare malignancies associated with occupational exposures. The aim of this study was to analyse the survival of SNC patients using data from the population-based SNC registry of the Lombardy region (10 million people), Italy. We included epithelial SNC cases registered in 2008–2020 and followed-up for vital status until 31 July 2023. Multivariate flexible parametric models with time-dependent covariates were fitted to calculate excess hazard ratios (EHRs) and 95% confidence intervals (CIs) of death. Based on 827 cases (553 males, 274 females) and 514 deaths (345 males, 169 females), the 5-year observed survival was 49% and the net survival was 57%. Age had a substantial impact on survival, particularly within the first year (EHR, 1.35; 95% CI, 1.12–1.51 per 10 years). Compared with the nasal cavity, the EHR for paranasal sinuses was 4.70 (95% CI, 2.96–7.47) soon after diagnosis. Compared with squamous cell carcinomas, the EHR was 0.69 (95% CI, 0.52–0.91) for adenocarcinomas, 1.68 (95% CI, 1.20–2.35) for undifferentiated and unspecified carcinomas, and 1.78 (95% CI, 1.07–2.95) for neuroendocrine carcinomas. Age and cancer site showed time-dependent effects on prognosis, especially within the first month after diagnosis. Prognosis was also markedly affected by cancer morphology. No associations were found for gender and period of diagnosis.

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Dermato-allergological risks in beauty operators

Lauriola

Corazza

2023

Ital J Dermatol Venereol

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Exposures to IARC Carcinogenic Agents in Work Settings Not Traditionally Associated with Sinonasal Cancer Risk: The Experience of the Italian National Sinonasal Cancer Registry

Cited by 5 publications

References 24 publications

Sinonasal cancer incidence in Lombardy, Italy, 2008–20

Sinonasal cancer incidence in Lombardy, Italy, 2008–20

Survival of Patients with Sinonasal Cancers in a Population-Based Registry, Lombardy, Italy, 2008–2023

Dermato-allergological risks in beauty operators

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