Exposures to chemical contaminants: What can we learn from reproduction and development endpoints in the amphibian toxicology literature?

Slaby, Sylvain; Marin, Matthieu; Marchand, Guillaume; Lemière, Sébastien

doi:10.1016/j.envpol.2019.02.014

Cited by 43 publications

(12 citation statements)

References 101 publications

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“…There are advantages to using organisms such as D. rerio or Xenopus sp. in environmental toxicology studies [ 97 , 98 , 99 ]. Both models share a short life cycle [ 100 , 101 ], which can be studied from the oogenesis period to the late development in controlled conditions.…”

Section: Perspectives: Interests Of Biological Models To Study the Effects Of Aluminium On The Nervous System Of Aquatic Vertebratesmentioning

confidence: 99%

Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review

Closset

Cailliau

Slaby

et al. 2021

IJMS

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Aluminium (Al) is the most common natural metallic element in the Earth’s crust. It is released into the environment through natural processes and human activities and accumulates in aquatic environments. This review compiles scientific data on the neurotoxicity of aluminium contamination on the nervous system of aquatic organisms. More precisely, it helps identify biomarkers of aluminium exposure for aquatic environment biomonitoring in freshwater aquatic vertebrates. Al is neurotoxic and accumulates in the nervous system of aquatic vertebrates, which is why it could be responsible for oxidative stress. In addition, it activates and inhibits antioxidant enzymes and leads to changes in acetylcholinesterase activity, neurotransmitter levels, and in the expression of several neural genes and nerve cell components. It also causes histological changes in nerve tissue, modifications of organism behaviour, and cognitive deficit. However, impacts of aluminium exposure on the early stages of aquatic vertebrate development are poorly described. Lastly, this review also poses the question of how accurate aquatic vertebrates (fishes and amphibians) could be used as model organisms to complement biological data relating to the developmental aspect. This “challenge” is very relevant since freshwater pollution with heavy metals has increased in the last few decades.

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Section: Perspectives: Interests Of Biological Models To Study the Effects Of Aluminium On The Nervous System Of Aquatic Vertebratesmentioning

confidence: 99%

Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review

Closset

Cailliau

Slaby

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…(Cushman, 2006;Shuman-Goodier et al, 2017;Pounds et al, 2006); Falaschi et al, 2020;Alford et al, 2007). To be susceptible to contamination because of their semipermeable skins is another disadvantage of amphibians (Egea-Serrano et al, 2012;Slaby et al, 2019). The other major threating factors on amphibian populations are fertilizers and other agrochemicals such as nitrogenous compounds (Krishnamurthy and Smith, 2010;2011;Trudeau et al, 2020;Van Meter et al, 2019;Marco and Ortiz-Santaliestra, 2009;Baker et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of Environmentally Relevant Ammonium Nitrate Levels Caused by Agricultural Activities on Four Amphibian Species in The Eastern Black Sea Region

Karaoglu

2022

Turkish JAF Sci.Tech.

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Within the scope of this research, the chronic effects of ammonium nitrate, which is the most widely used fertilizer worldwide, on the tadpoles of Marsh Frog (Pelophylax ridibundus), the Iranian Long-Legged Frog (Rana macrocnemis), the Caucasian Parsley Frog (Pelodytes caucasicus) and the Variable Green Toad (Bufotes variabilis) were examined. To assess the chronic effects of the fertilizer, the tadpoles of all the species were exposed to 0, 5, 10, 15, 20, 25 mg/L concentrations in same conditions. The chronic concentrations were applied from the 25th developmental stage to the 42nd developmental stage. It was defined at the end of the experiments that although there were some variability between different populations of the same species or between different species in the observed effects, chronic levels of ammonium nitrate caused decreased growth rate, prolonging in time to complete metamorphosis, increased abnormalities, and mortality in general. Among the 4 amphibian species, the Variable Green Toad was the most damaged one in terms of growth reduction (on average 31-41 %), abnormality rates (on average 50-75 %), prolonged time to complete metamorphose (14-21 days on average) and mortality rates (%54-100). The most adaptive species and the least damaged one was an Iranian long-legged frog for growth reduction (on average 0-15 %), prolonged time to complete metamorphose (7-9 days on average), and mortality rates (%9-15). All the harmful effects of chronic fertilizer levels caused by agricultural activities in the region had very important for examined species in our researches and it can be said that important environmental and biodiversity problems may occur if certain precautions are not taken regarding the use of the fertilizers and if the attitudes of the farmers on this issue cannot be changed.

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“…(Shuman-Goodier et al, 2017;Pounds et al, 2006;Falaschi et al, 2020;Alford et al, 2007). To be susceptible to contamination because of their semi-permeable skins is another disadvantage of amphibians (Egea-Serrano et al, 2012;Slaby et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effects of Acute Ammonium Nitrate Levels Caused by Agricultural Activities on Four Amphibian Species in The Eastern Black Sea Region

Karaoglu

2022

Turkish JAF Sci.Tech.

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The tadpoles of four amphibian species, namely the Marsh Frog (Pelophylax ridibundus), the Iranian Long-Legged Frog (Rana macrocnemis), the Caucasian Parsley Frog (Pelodytes caucasicus) and the Variable Green Toad (Bufotes variabilis), were exposed to acute concentrations (0 to 500 mg/L) of ammonium nitrate to assess the lethal effects (larval growth, abnormalities, mortality, and LC50 values). Eggs of each species were obtained from clean and polluted habitats in the same region and the tadpoles for experiments were provided from those eggs in the laboratory conditions. Although there was some variability between different populations of the same species or between different species in the observed effects, acute levels of ammonium nitrate caused decreased growth rate and increased abnormalities and mortality in general. Among the 4 amphibian species, the Variable Green Toad was the most damaged one in terms of growth reduction (on average 77-83%), and abnormality rates, and the most damaged one in terms of mortality rates was the Marsh Frog (on average 61-72%). Additionally, the species with the lowest concentration of ammonium nitrate, which killed half of its population, was the Marsh Frog. LC50 values for two populations of Marsh Frog were 37 and 59 mg/L. As a result of our research, it was determined that the acute fertilizer levels caused by agricultural activities in the region had very important harmful effects for all the species we examined. In this context, it can be said that very important environmental and biodiversity problems may occur if certain precautions are not taken regarding the use of the fertilizers and if the awareness of the farmers using these fertilizers cannot be raised.

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Exposures to chemical contaminants: What can we learn from reproduction and development endpoints in the amphibian toxicology literature?

Cited by 43 publications

References 101 publications

Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review

Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review

Effects of Environmentally Relevant Ammonium Nitrate Levels Caused by Agricultural Activities on Four Amphibian Species in The Eastern Black Sea Region

Effects of Acute Ammonium Nitrate Levels Caused by Agricultural Activities on Four Amphibian Species in The Eastern Black Sea Region

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