Exposure to ultraviolet radiation: association with susceptibility and age at presentation with prostate cancer

Luscombe, Christopher J.; Fryer, Anthony A.; French, Morris L. V.; Liu, Samson; Saxby, Mark F.; Jones, Peter W.; Strange, Richard C.

doi:10.1016/s0140-6736(01)05788-9

Cited by 193 publications

(147 citation statements)

References 4 publications

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“…Thus, it was concluded that UVB had a protective effect against development of prostate cancer. 28 In 1992, Hanchette and Schwartz 22 proposed that sunlight and vitamin D may play a role in prostate cancer. Mortality rates in the United States from prostate cancer showed a negative correlation with UVB exposure.…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

“…21 Both body mass index and lean body mass were positively associated with the risk of prostate cancer and were more strongly related to mortality than to incidence. Other factors that influence the occurrence of the disease are dietary habits (diet that includes a high intake of fat, meat and dairy products), 22,23 pattern of sexual behavior, alcohol consumption, 24 exposure to ultraviolet radiation, 22,[25][26][27][28] occupational exposure 29 and familial genetic inheritance. 5,[30][31][32][33][34][35] Finally, factors such as smoking, 36 vasectomy 37 and physical activity 38 have been investigated in several studies, but the general consensus is that they do not affect risk of prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D and prostate cancer risk: a review of the epidemiological literature

Gupta

Lammersfeld

Trukova

et al. 2009

Prostate Cancer Prostatic Dis

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Prostate cancer is the most commonly diagnosed cancer in the United States. Prostate cells contain vitamin D receptors as well as enzymes necessary for vitamin D metabolism. Vitamin D metabolites have an antiproliferative and a pro-differentiating effect on prostate cancer cell lines in vitro and in vivo. As a result, there has been an emerging interest in the potential role of vitamin D in the etiology of prostate cancer. This review summarizes all available epidemiological literature on the association between dietary vitamin D, circulating levels of vitamin D and sunlight exposure in relation to prostate cancer risk. To place these studies in context, we also provide some background information on vitamin D, such as its dietary sources, metabolism, optimal levels, hypovitaminosis and relationship with the prostate.

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Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D and prostate cancer risk: a review of the epidemiological literature

Gupta

Lammersfeld

Trukova

et al. 2009

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

show abstract

“…Based on the observation that the descriptive epidemiology of prostate cancer resembles that of vitamin D insufficiency, Schwartz and Hulka (1990) proposed that vitamin D maintained the differentiated phenotype of prostate cells and that low levels of vitamin D increase the risk for prostate cancer. Many subsequent epidemiologic (Ahonen et al, 2000;Luscombe et al, 2001) and laboratory studies (Feldman et al, 2000) have supported this hypothesis. For example,1a,25(OH) analogues exhibit significant growth-inhibitory, proapoptotic, anti-invasive and antimetastatic effects on prostate tumour cell lines in vitro and in vivo (Miller et al, 1992;Peehl et al, 1994;Schwartz et al, 1995Schwartz et al, , 1997Skowronski et al, 1995;Asou et al, 1998;Lokeshwar et al, 1999;Blutt et al, 2000;Seol et al, 2000).…”

mentioning

confidence: 93%

1α,25-Dihydroxyvitamin D3 (calcitriol) and its analogue, 19-nor-1α,25(OH)2D2, potentiate the effects of ionising radiation on human prostate cancer cells

et al. 2003

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Radiotherapy with external beam radiation or brachytherapy is an established therapeutic modality for prostate cancer. Approximately 30% of patients with localised prostate cancer relapse at the irradiated site. Secondary effects of ionising radiation (IR), for example, bowel and bladder complications, are common. Thus, the search for biological response modifiers that could potentiate the therapeutic effects of radiation and limit the occurrence of serious side effects is an important task in prostate cancer therapy.

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“…Although data are sparse, some evidence suggests that prostate cancer risk may be influenced by sun exposure early in life (6,7). Most previous studies have focused on the effect of sun exposure during adulthood, and the effect of sun exposure in early life has been little explored.…”

Section: Introductionmentioning

confidence: 99%

Sun Exposure and Prostate Cancer Risk: Evidence for a Protective Effect of Early-Life Exposure

John

Koo

Schwartz

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Mounting experimental and epidemiologic evidence supports the hypothesis that vitamin D reduces the risk of prostate cancer. Some evidence suggests that prostate cancer risk may be influenced by sun exposure early in life. We analyzed data from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study to examine associations of prostate cancer risk with early-life and adult residential sun exposure and adult sun exposures that were assessed through self-report, physician report, and dermatologic examination. We used solar radiation in the state of birth as a measure of sun exposure in early life. Follow-up from 1971Follow-up from to 1975 to 1992 identified 161 prostate cancer cases (102 nonfatal and 59 fatal) among non-Hispanic white men for whom sun exposure data were available. Significant inverse associations were found for men born in a region of high solar radiation (relative risk, 0.49, 95% confidence interval, 0.27-0.90 for high versus low solar radiation), with a slightly greater reduction for fatal than for nonfatal prostate cancer. Frequent recreational sun exposure in adulthood was associated with a significantly reduced risk of fatal prostate cancer only (relative risk, 0.47; 95% confidence interval, 0.23-0.99). These findings suggest that, in addition to sun exposure in adulthood, sun exposure in early life protects against prostate cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1283 -6)

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Exposure to ultraviolet radiation: association with susceptibility and age at presentation with prostate cancer

Cited by 193 publications

References 4 publications

Vitamin D and prostate cancer risk: a review of the epidemiological literature

Vitamin D and prostate cancer risk: a review of the epidemiological literature

1α,25-Dihydroxyvitamin D3 (calcitriol) and its analogue, 19-nor-1α,25(OH)2D2, potentiate the effects of ionising radiation on human prostate cancer cells

Sun Exposure and Prostate Cancer Risk: Evidence for a Protective Effect of Early-Life Exposure

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