Exposure to Traffic-Related Air Pollution and Noise and the Development of Respiratory Diseases in Children

Ising, H; Lange-Asschenfeldt, H; Lieber, Gert-Friedhelm; Moriske, Heinz-Jörn; Weinhold, H

doi:10.3109/15417060490906477

Cited by 12 publications

(10 citation statements)

References 13 publications

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“…Even though there was a statistically significant slope for IL-5 as a function of metals at the 150m site while the slope at 50 m was not statistically significant, the numerical value of the slope at 50 m was slightly greater than that at 150 m. The significant slope could be a chance occurrence or there could be a proallergenic effect of metal ions. Our data are consistent with, and support, epidemiological findings that people living near heavily trafficked roadways are more likely to exhibit symptoms of asthma and other respiratory diseases than will individuals living at greater distances from roadways (Edwards et al, 1994;Ciccone et al, 1998;English et al, 1999;Ising et al, 2003).…”

Section: Discussionsupporting

confidence: 94%

Inhalation of Concentrated Ambient Particulate Matter Near a Heavily Trafficked Road Stimulates Antigen-Induced Airway Responses in Mice

Kleinman

Sioutas

Froines

et al. 2007

Inhalation Toxicology

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Motor vehicle exhaust emissions are known to exacerbate asthma and other respiratory diseases. Several studies have demonstrated significant associations between living near highly trafficked roadways and increased incidence of asthma and increased severity of asthma-related symptoms, medication usage, and physician visits. This study tested the hypotheses that (1) exposure to particulate matter (PM) near a heavily trafficked Los Angeles freeway would enhance inflammatory and allergic responses in ovalbumin (OVA)-sensitized BALB/c mice compared to sensitized, clean air controls, and (2) there would be differences in response at two distances downwind of heavily traveled freeways because of greater toxicity of PM closest to the freeway. An ambient particle concentrator was used to expose ovalbumin (OVA)-treated BALB/c mice to purified air, to concentrated fine ambient particles, and to concentrated ultrafine airborne particles (CAPs) at 2 distances, 50 m and 150 m, downwind of a roadway that is impacted by emissions from both heavy-duty diesel and light duty gasoline vehicles. Tissues and biological fluids from the mice were analyzed after exposures for 5 days/wk in 2 consecutive weeks. The biomarkers of allergic or inflammatory responses that were assessed included cytokines released by Type 2 T-helper cells (interleukin [IL]-5 and IL-13), OVA-specific immunoglobulin E (IgE), OVA-specific immunoglobulin G1 (IgG1), and pulmonary infiltration of polymorphonuclear leukocytes and eosinophils. IL-5 and IgG1 were significantly increased in mice exposed to CAPs 50 m downwind of the road, compared to responses in mice exposed to purified air, providing evidence of allergic response. No significant increases in allergy-related responses were observed in mice exposed to CAPs 150 m downwind of the road. The biological responses at the 50-m site were significantly associated with organic and elemental carbon components of fine and ultrafine particles (p < or = .05). The primary source of these contaminants at the roadway sites was motor vehicle emissions, suggesting that particulate matter from motor vehicle fuel combustion could exert adjuvant effects and promote the development of allergic airway diseases.

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Section: Discussionsupporting

confidence: 94%

Inhalation of Concentrated Ambient Particulate Matter Near a Heavily Trafficked Road Stimulates Antigen-Induced Airway Responses in Mice

Kleinman

Sioutas

Froines

et al. 2007

Inhalation Toxicology

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“…The association of L eqt with respiratory causes is apparently surprising but it has been reported before in other recent studies (Ising et al 2003(Ising et al , 2004, in which the combined effects of chronic exposure to traffic-related air pollution and noise upon the risk of skin and respiratory diseases in children and adults (Niemann and Maschke 2004) were studied. The results obtained suggest that the associations indicating the short-term effects of exposure to high noise levels are nonspurious and point out that the current levels of environmental noise have a considerable epidemiological impact on the emergency hospital admission of children due to organic and respiratory causes.…”

Section: Discussionmentioning

confidence: 76%

“…Noise levels can also be considered an environmental pollutant and in the last decade an increasing number of studies have focussed on the role of environmental noise on health (Ising et al 2003;Ising et al 2004). But there are really few studies analysing the impact of noise on children.…”

Section: Introductionmentioning

confidence: 98%

Impact of urban air pollutants and noise levels over daily hospital admissions in children in Madrid: a time series analysis

Linares

Díaz

Tobías

et al. 2005

Int Arch Occup Environ Health

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“…[16][17][18][19][20] Despite the recognized need to consider noise and stress as potential confounders of air pollution effects, 15 relatively few studies of traffic impacts on health have considered noise in risk models. 17,21 Urban air pollution monitoring studies in New York City (NYC) have indicated significant spatial variation in traffic-related air pollutants, 22,23 but less data is available to characterize intraurban spatial variation in noise. An understanding of the shared patterns of noise and air pollution exposures within complex urban environments such as NYC could help inform exposure assessment and epidemiologic research.…”

Section: Introductionmentioning

confidence: 99%

Spatial Variation in Environmental Noise and Air Pollution in New York City

et al. 2014

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Exposure to environmental noise from traffic is common in urban areas and has been linked to increased risks of adverse health effects including cardiovascular disease. Because traffic sources also produce air pollutants that increase the risk of cardiovascular morbidity, associations between traffic exposures and health outcomes may involve confounding and/or synergisms between air pollution and noise. While prior studies have characterized intraurban spatial variation in air pollution in New York City (NYC), limited data exists on the levels and spatial variation in noise levels. We measured 1-week equivalent continuous sound pressure levels (L eq ) at 56 sites during the fall of 2012 across NYC locations with varying traffic intensity and building density that are routinely monitored for combustion-related air pollutants. We evaluated correlations among several noise metrics used to characterize noise exposures, including L eq during different time periods (night, day, weekday, weekend), L dn (day-night noise), and measures of intermittent noise defined as the ratio of peak levels to median and background levels. We also examined correlations between sound pressure levels and co-located simultaneous measures of nitric oxide (NO), nitrogen dioxide (NO 2 ), fine particulate matter (PM 2.5 ), and black carbon (BC) as well as estimates of traffic and building density around the monitoring sites. Noise levels varied widely across the 56 monitoring sites; 1-week L eq varied by 21.6 dBA (range 59.1-80.7 dBA) with the highest levels observed during the weekday, daytime hours. Indices of average noise were well correlated with each other (r9 0.83), while indices of intermittent noise were not well correlated with average noise levels (rG0.41). One-week L eq correlated well with NO, NO 2 , and EC levels (r=0.61 to 0.68) and less so with PM 2.5 levels (r=0.45). We observed associations between 1-week noise levels and traffic intensity within 100 m of the monitoring sites (r = 0.58). The high levels of noise observed in NYC often exceed recommended guidelines for outdoor and personal exposures, suggesting unhealthy levels in many locations. Associations between noise, traffic, and combustion air pollutants suggest the possibility for confounding and/or synergism in intraurban epidemiological studies of traffic-related health effects. The different spatial pattern of intermittent noise compared to average noise level may suggest different sources.Kheirbek, Ito, Kim, Johnson, and Matte are with the New York City

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Exposure to Traffic-Related Air Pollution and Noise and the Development of Respiratory Diseases in Children

Cited by 12 publications

References 13 publications

Inhalation of Concentrated Ambient Particulate Matter Near a Heavily Trafficked Road Stimulates Antigen-Induced Airway Responses in Mice

Inhalation of Concentrated Ambient Particulate Matter Near a Heavily Trafficked Road Stimulates Antigen-Induced Airway Responses in Mice

Impact of urban air pollutants and noise levels over daily hospital admissions in children in Madrid: a time series analysis

Spatial Variation in Environmental Noise and Air Pollution in New York City

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