Exposure to tobacco smoke increases leukotriene E4–related albuterol usage and response to montelukast

Rabinovitch, Nathan; Strand, Matthew; Stuhlman, Kate; Gelfand, Erwin W.

doi:10.1016/j.jaci.2008.03.016

Cited by 48 publications

(33 citation statements)

References 41 publications

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“…There is an increased predictive value of using combinations of biomarkers to predict therapeutic responses. A recent study demonstrated that a high ratio of urinary LTE 4 to FeNO was associated with increased responsiveness to LT receptor antagonists compared to inhaled corticosteroids [31]. This group of subjects with comparatively higher cys-LT / FeNO ratio tended to have less allergic, more neutrophil driven airway disease as seen in rhinovirus infections, and smokers [32,33].…”

Section: Introductionmentioning

confidence: 94%

Relationship between cysteinyl leukotrienes and nitric oxide in the pathogenesis of asthma in obesity

Coffey¹,

Torretti²,

Baptist³

2017

J Allergy Asthma

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Background: Obesity has become a lot more prevalent recently, and its involvement with pathogenesis of asthma is frequently investigated. Aims: We hypothesize that altered plasma adipoikines and exhaled nitric oxide (NO) levels in obese subjects upregulate inflammation in asthmatics. We examined the hypothesis that the inflammatory mediators, cysteinyl leukotrienes (cys-LT) which are regulated by leptin and NO, play a role in the pathogenesis of airway inflammation in obese asthmatics. Methods: We studied asthmatics (n=59) and non-asthmatics (n=58), both obese and non-obese, and further analyzed by gender. We examined plasma leptin, and fractional exhaled nitric oxide (FeNO), in obese and non-obese asthmatics and non-asthmatics. In addition, we measured urinary cys-LT levels in these subjects. Results: Plasma leptin was increased in asthmatics compared to non-asthmatics (34.5±31 vs. 27.0±26, p=0.038), specifically in obese female asthmatics compared to obese male asthmatics (65.1±22.5 vs. 26.2±15.9 ng/ml, p=0.01). FeNO were decreased in obese compared to non-obese asthmatics (17.8±9.3 vs. 29.5±22.4, p=0.04), an effect that was most noted in female asthmatics. Urinary cys-LT levels were elevated in female asthmatic (7.2±2.9 vs. 5.0±1.8, p=0.002), especially in older heavier subjects. The ratio of urinary cys-LT to FeNO was elevated in obese female asthmatics. Conclusions: Pro-inflammatory leptin and anti-inflammatory NO are altered in obese asthmatics. These mediators may regulate cys-LT. The group of subjects with elevated cys-LT/FeNO ratios may be a target for selective therapy.

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Section: Introductionmentioning

confidence: 94%

Relationship between cysteinyl leukotrienes and nitric oxide in the pathogenesis of asthma in obesity

Coffey¹,

Torretti²,

Baptist³

2017

J Allergy Asthma

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“…In addition, their levels might be increased in nonallergic asthma patients such as passive exposure to smoke or virus-induced wheezing. 22,23 They cause edema by increasing vascular permeability, and are also responsible for the mucous secretions, bronchoconstruction, and cellular infiltration seen in asthma clinics. Selective Cys-LT receptor antagonists are effective in some asthma patients.…”

Section: Discussionmentioning

confidence: 99%

Urine Leukotriene E4 Levels in Children with Nonspecific Isolated Chronic Dry Cough

Asilsoy¹,

Bayram²,

Can³

2013

Pediatric Allergy, Immunology, and Pulmonology

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Chronic cough is the most common complaint during childhood. Various pathophysiologic mechanisms may cause cough. Knowledge of the mechanisms underlying chronic cough plays an important role in the choice of treatment to evaluate the role of leukotrienes in children with nonspecific isolated chronic dry cough. The patient group consisted of children with isolated chronic dry cough persisting for > 4 weeks and the control group included healthy children. Medical histories were elicited and physical examinations were performed, then respiratory function testing was done and chest X-rays were obtained. Patients were given inhaled corticosteroid. The urine leukotriene E4 (uLTE4) levels in the patient and control groups was measured by enzyme immunoassay. The patient group included 55 patients, 25 of them were males between 6 and 12 years old. The control group included 25 healthy children between 6 and 12 years old, 12 of them were males. There were no pathologic findings on physical examinations, pulmonary function testing, and chest X-rays. The complaints of cough in 50 patients were resolved after treatment. The median level of uLTE4 was 73.1 ng/mmol creatinine (range, 15.59-787.55 ng/mmol creatinine) in the patient group, and 64.2 ng/mmol creatinine (range, 12-282 ng/ mmol creatinine) in the control group. No significant difference was detected between the 2 groups with respect to age, gender, and uLTE4 levels. Different pathophysiologic mechanisms are known to influence nonspecific isolated chronic dry cough. Various mechanisms, other than leukotrienes, may also give rise to dry cough.

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“…After 2.5 months, treatment with montelukast significantly reduced albuterol usage, especially in girls and in children with higher cotinine levels ( Figure 5). In addition, children with high LTE 4 levels relative to FENO demonstrated significant declines in albuterol usage [124]. In an 18-week study, Szefler and colleagues evaluated markers associated with clinical response to ICS and LTRA in 126 children (aged 6-17 years) with mild-tomoderate persistent asthma in a double-blind, two-way crossover study, including 8 weeks' treatment with either fluticasone (100 µg twice daily) or montelukast (5-10 mg once daily).…”

Section: Montelukast In the Treatment Of Asthma And Beyondmentioning

confidence: 98%

“…Use of albuterol was monitored daily. During the baseline interval, urine LTE 4 levels in all subjects were strongly associated with increased albuterol use Redrawn with permission from [124].…”

Section: Montelukast In the Treatment Of Asthma And Beyondmentioning

confidence: 99%

Montelukast in the treatment of asthma and beyond

Diamant¹,

Mantzouranis

Bjermer

2009

Expert Review of Clinical Immunology

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Exposure to tobacco smoke increases leukotriene E4–related albuterol usage and response to montelukast

Cited by 48 publications

References 41 publications

Relationship between cysteinyl leukotrienes and nitric oxide in the pathogenesis of asthma in obesity

Relationship between cysteinyl leukotrienes and nitric oxide in the pathogenesis of asthma in obesity

Urine Leukotriene E4 Levels in Children with Nonspecific Isolated Chronic Dry Cough

Montelukast in the treatment of asthma and beyond

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