Exposure to tobacco smoke during the early postnatal period modifies receptors and enzymes of the endocannabinoid system in the brainstem and striatum in mice

Torres, Larissa Helena; Balestrin, Natalia T.; Spelta, Lídia Emmanuela Wiazowski; Duro, Stephanie de Oliveira; Pistis, Marco; Marcourakis, Tânia

doi:10.1016/j.toxlet.2018.12.002

Cited by 12 publications

(11 citation statements)

References 57 publications

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“…The brainstem is associated with respiratory and cardiovascular responses, therefore is related to pathogenesis of SIDS and it is susceptible to ETS exposure. Previous studies showed that exposure to ETS in the early postnatal period decreased myelin-specific proteins and alter receptors and enzymes of the endocannabinoid system in the brainstem (Torres et al, 2015a(Torres et al, , 2019a. The present study corroborates these findings since we observed that ETS exposure decreased 18 F-FDG uptake in ETS-exposed male mice compared with female mice and increased 18 F-FDG uptake in ETS-exposed female mice compared with control group.…”

Section: Discussionsupporting

confidence: 91%

Environmental Tobacco Smoke During the Early Postnatal Period of Mice Interferes With Brain 18 F-FDG Uptake From Infancy to Early Adulthood – A Longitudinal Study

et al. 2020

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Exposure to environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in childhood. Our aim was to evaluate the effects of postnatal ETS exposure in the brain 2-deoxy-2-[ 18 F]-fluoro-D-glucose (18 F-FDG) uptake of mice by positron emission tomography (PET) neuroimaging in a longitudinal study. C57BL/6J mice were exposed to ETS that was generated from 3R4F cigarettes from postnatal day 3 (P3) to P14. PET analyses were performed in male and female mice during infancy (P15), adolescence (P35), and adulthood (P65). We observed that ETS exposure decreased 18 F-FDG uptake in the whole brain, both left and right hemispheres, and frontal cortex in both male and female infant mice, while female infant mice exposed to ETS showed decreased 18 F-FDG uptake in the cerebellum. In addition, all mice showed reduced 18 F-FDG uptake in infancy, compared to adulthood in all analyzed VOIs. In adulthood, ETS exposure during the early postnatal period decreased brain 18 F-FDG uptake in adult male mice in the cortex, striatum, hippocampus, cingulate cortex, and thalamus when compared to control group. ETS induced an increase in 18 F-FDG uptake in adult female mice when compared to control group in the brainstem and cingulate cortex. Moreover, male ETS-exposed animals showed decreased 18 F-FDG uptake when compared to female ETS-exposed in the whole brain, brainstem, cortex, left amygdala, striatum, hippocampus, cingulate cortex, basal forebrain and septum, thalamus, hypothalamus, and midbrain. The present study shows that several brain regions are vulnerable to ETS exposure during the early postnatal period and these

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Section: Discussionsupporting

confidence: 91%

Environmental Tobacco Smoke During the Early Postnatal Period of Mice Interferes With Brain 18 F-FDG Uptake From Infancy to Early Adulthood – A Longitudinal Study

et al. 2020

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“…away from a caregiver who routinely smokes (level 1) 28 and clothing or objects that smell of smoke (thirdhand smoke) (level 5). 45 (In cases where the mother smokes, this will not be possible). 5.…”

Section: Place Infants To Sleep Away From Secondhand Smoke Andmentioning

confidence: 99%

Bedsharing and Breastfeeding: The Academy of Breastfeeding Medicine Protocol #6, Revision 2019

Blair

Ball

McKenna

et al. 2020

Breastfeeding Medicine

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A central goal of the Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient. Purpose B edsharing promotes breastfeeding initiation, 1 duration, 2-7 and exclusivity. 7,8 Medical and public health organizations in some countries recommend against bedsharing, citing concerns over increased risk of sleeprelated infant death. 9,10 However, bedsharing may only be a risk in hazardous circumstances as demonstrated by epidemiological study (Table 1). 11 We aim to clarify the currently available evidence regarding the benefits and risks of bedsharing, and offer evidence-based recommendations that promote infant and maternal health through increased breastfeeding duration. 12 The recommendations in this protocol apply to mother-infant dyads who have initiated breastfeeding and are in home settings, and are not intended for use in hospitals or birth centers.

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“…Place infants to sleep away from second-hand smoke and away from a caregiver who routinely smokes 28 (1) and clothing or objects that smell of smoke (third-hand smoke). 45 (5) (In cases where the mother smokes, this will not be possible). 5.…”

Section: Table 1 Hazardous Risk Factors or Circumstances During Bed Sharingmentioning

confidence: 99%

Bedsharing and Breastfeeding: The Academy of Breastfeeding Medicine Protocol #6, Revision 2019

et al. 2022

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Exposure to tobacco smoke during the early postnatal period modifies receptors and enzymes of the endocannabinoid system in the brainstem and striatum in mice

Cited by 12 publications

References 57 publications

Environmental Tobacco Smoke During the Early Postnatal Period of Mice Interferes With Brain 18 F-FDG Uptake From Infancy to Early Adulthood – A Longitudinal Study

Environmental Tobacco Smoke During the Early Postnatal Period of Mice Interferes With Brain 18 F-FDG Uptake From Infancy to Early Adulthood – A Longitudinal Study

Bedsharing and Breastfeeding: The Academy of Breastfeeding Medicine Protocol #6, Revision 2019

Bedsharing and Breastfeeding: The Academy of Breastfeeding Medicine Protocol #6, Revision 2019

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