Exposure to the Chinese Famine in Childhood Increases Type 2 Diabetes Risk in Adults

Wang, Jing; Li, Yaru; Han, Xu; Liu, Bing; Hu, Hua; Wang, Fei; Li, Xiulou; Yang, Kun; Yuan, Jing; Yao, Ping; Miao, Xiaoping; Wei, Sheng; Wang, Youjie; Liang, Yuan; Zhang, Xiaomin; Guo, Huan; Yang, Handong; Hu, Frank B.; Wu, Tangchun; He, Meian

doi:10.3945/jn.116.234575

Cited by 81 publications

(93 citation statements)

References 33 publications

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“…Similar findings have been demonstrated in previous studies of large populations subject to prolonged periods of famine and distress during times of war . Holocaust survivors with posttraumatic stress disorder (PTSD) had higher rates of myocardial infarction, chronic diseases, and cancer than individuals with PTSD from other traumatic events .…”

Section: Discussionsupporting

confidence: 82%

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Cardiovascular Morbidity and Risk Factors in Holocaust Survivors in Israel

Zamstein

Biderman

Sherf

et al. 2018

J American Geriatrics Society

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Section: Discussionsupporting

confidence: 82%

“…Other studies assessing morbidity in Dutch famine survivors found higher body mass index and higher cardiovascular mortality in exposed women but not men. Similar sex‐related findings were found in famine studies conducted in Biafra, China, and Austria …”

mentioning

confidence: 99%

Cardiovascular Morbidity and Risk Factors in Holocaust Survivors in Israel

Zamstein

Biderman

Sherf

et al. 2018

J American Geriatrics Society

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“…Animal studies have reported that prolonged postnatal malnutrition impairs β‐cell development . Some studies on the Great Chinese Famine also showed that famine in childhood was related to an increased risk of adulthood T2DM and hyperglycemia …”

Section: Discussionmentioning

confidence: 70%

“…Several studies on the association between the Great Chinese Famine and the risk of T2DM or metabolic syndrome have been published . Unfortunately, few studies were conducted nationwide.…”

Section: Introductionmentioning

confidence: 99%

Association between famine exposure in early life and type 2 diabetes mellitus and hyperglycemia in adulthood: Results from the China Health And Retirement Longitudinal Study (CHARLS)

Sun

Zhang

Duan

et al. 2018

Journal of Diabetes

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For females, the risk of hyperglycemia was higher for famine-exposed than not exposed cohort (odds ratios [OR] 1.34 and 95% confidence intervals [CIs]: 1.34 [1.04-1.74], 1.48 [1.15-1.90], 1.38 [1.06-1.79], and 1.57 [1.25-1.98] for fetal, early, middle, and late childhood exposure, respectively), and this association was even stronger in female participants who lived in rural areas before the age of 16 years. In males, the risk of T2DM was lower for the early and late childhood exposure than no exposure cohorts (OR [95% CIs]: 0.65 [0.49-0.86] and 0.74 [0.56-0.98], respectively). [Correction added on 23 July 2018, after first online publication: Parts of the above 'Results' section have been corrected to interchange the citation of the words 'late' and 'early'.] CONCLUSION: Exposure to famine during early life can increase the risk of hyperglycemia in female adults, but may decrease the risk of T2DM in males.

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“…A significant interaction between the level of famine severity in the areas of exposure throughout the prenatal and childhood periods and the risk of T2D in adulthood has been observed. In another Chinese population, 1.44-fold higher risk of T2D development in the middle-childhood-exposed group, and 1.5-fold higher risks of hyperglycaemia in both the middle- and late-childhood-exposed groups were demonstrated compared to the unexposed group [72]. Remarkably, those individuals who experienced more severe famine in childhood had a 38% higher risk of T2D development than those exposed to less severe famine.…”

Section: Quasi-experimental Design In Studying the Developmental Omentioning

confidence: 99%

Early-Life Nutritional Programming of Type 2 Diabetes: Experimental and Quasi-Experimental Evidence

Vaiserman

2017

Nutrients

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Consistent evidence from both experimental and human studies suggest that inadequate nutrition in early life can contribute to risk of developing metabolic disorders including type 2 diabetes (T2D) in adult life. In human populations, most findings supporting a causative relationship between early-life malnutrition and subsequent risk of T2D were obtained from quasi-experimental studies (‘natural experiments’). Prenatal and/or early postnatal exposures to famine were demonstrated to be associated with higher risk of T2D in many cohorts around the world. Recent studies have highlighted the importance of epigenetic regulation of gene expression as a possible major contributor to the link between the early-life famine exposure and T2D in adulthood. Findings from these studies suggest that prenatal exposure to the famine may result in induction of persistent epigenetic changes that have adaptive significance in postnatal development but can predispose to metabolic disorders including T2D at the late stages of life. In this review, quasi-experimental data on the developmental programming of T2D are summarized and recent research findings on changes in DNA methylation that mediate these effects are discussed.

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Exposure to the Chinese Famine in Childhood Increases Type 2 Diabetes Risk in Adults

Abstract: Exposure to the Chinese famine in childhood was related to an increased risk of adulthood T2D and hyperglycemia, particularly in women.

Cited by 81 publications

References 33 publications

Cardiovascular Morbidity and Risk Factors in Holocaust Survivors in Israel

Cardiovascular Morbidity and Risk Factors in Holocaust Survivors in Israel

Association between famine exposure in early life and type 2 diabetes mellitus and hyperglycemia in adulthood: Results from the China Health And Retirement Longitudinal Study (CHARLS)

Early-Life Nutritional Programming of Type 2 Diabetes: Experimental and Quasi-Experimental Evidence

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