Exposure to the Chinese Famine in Early Life and the Risk of Metabolic Syndrome in Adulthood

Li, Yanping; Lai, Jianghua; Jaddoe, Vincent W. V.; Zhang, Jian; Qi, Lü; Fu, Ping; He, Yao; Yang, Xiaoguang; Wang, Dong; Hu, Frank B.

doi:10.1097/ogx.0b013e31822b32a5

Cited by 44 publications

(67 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the evidence is conflicting, it may be that the detrimental effects of the Dutch famine extended into the following generation, with the offspring of women born in the famine found to have a lower birth weight [161,181]. Similar associations between early-life famine exposure and subsequent elevated chronic disease risk were reported following the Biafran conflict of 1968 to 1970 [182], and the Chinese famine of 1959 to 1961 [183][184][185][186]. In the latter, early-life exposure was also associated with increased risk of schizophrenia [187,188].…”

Section: Intergenerational Associationssupporting

confidence: 49%

Emotional Abuse Towards Children by Schoolteachers in Aden Governorate, Yemen: A Cross-Sectional Study

2015

Childhood Adversity and Developmental Effects

View full text Add to dashboard Cite

Background: The short-and medium-term effects of conflict on population health are reasonably well documented. Less considered are its consequences across generations and potential harms to the health of children yet to be born. Discussion: Looking first at the nature and effects of exposures during conflict, and then at the potential routes through which harm may propagate within families, we consider the intergenerational effects of four features of conflict: violence, challenges to mental health, infection and malnutrition. Conflict-driven harms are transmitted through a complex permissive environment that includes biological, cultural and economic factors, and feedback loops between sources of harm and weaknesses in individual and societal resilience to them. We discuss the multiplicative effects of ongoing conflict when hostilities are prolonged. Summary: We summarize many instances in which the effects of war can propagate across generations. We hope that the evidence laid out in the article will stimulate research and -more importantly -contribute to the discussion of the costs of war; particularly in the longer-term in post-conflict situations in which interventions need to be sustained and adapted over many years.

show abstract

Section: Intergenerational Associationssupporting

confidence: 49%

Emotional Abuse Towards Children by Schoolteachers in Aden Governorate, Yemen: A Cross-Sectional Study

2015

Childhood Adversity and Developmental Effects

View full text Add to dashboard Cite

show abstract

“…Existing studies based on the GLFF either relied on simple cohort comparison (Gorgens, Meng, and Vaithianathan 2011;Li et al 2011;Song 2009Song , 2010St Clair et al 2005) or DD analysis that utilised two sources of variation (Chen and Zhou 2007;Huang et al 2010a;Huang et al 2010b;Song 2013). The validity of the simple cohort comparison method rests on the assumption that, in the counterfactual absence of the famine influence, there is no cohort difference in the outcome of interest between the famine and non-famine cohorts.…”

Section: Methodsmentioning

confidence: 99%

Prenatal malnutrition and subsequent foetal loss risk: Evidence from the 1959-1961 Chinese famine

Song¹

2013

DemRes

View full text Add to dashboard Cite

BACKGROUNDScientists disagree on whether prenatal malnutrition has long-term influences on women's reproductive function, and empirical evidence of such long-term effects remains limited and inconsistent. METHODSUsing the retrospective pregnancy history of 12,567 Chinese women collected in a nationally representative sample survey in 2001, this study conducted difference-indifferences analyses to investigate the relationship between prenatal exposure to the 1959-1961 Great Leap Forward Famine in China and the subsequent risk of involuntary foetal loss, including miscarriage and stillbirth, and how this relationship changes between the rural and urban populations. RESULTSPrenatal exposure to the Great Leap Forward Famine had no long-term effect on women's risk of miscarriage. Such an exposure increased the risk of stillbirth among urban women but not among rural women. CONCLUSIONSThe results support the foetal origins hypothesis. The significant urban-rural difference in the effect of prenatal famine exposure on stillbirth suggests the presence of a longterm negative foetal origins effect and a strong selection effect caused by famineinduced population attrition.

show abstract

“…Many studies in human and animals reported that the adverse effects of prenatal malnutrition on the development of brain function, hypertension, metabolic syndrome in the adulthood [12][13][14][15]. In order to supply sufficient nutrients to the embryo, it is required for young women to have proper dietary habits and take sufficient nutrients for having healthy offspring.…”

Section: Introductionmentioning

confidence: 99%

Low Energy Intake Impairs Glucose Regulation And Stamina In Japanese Young Women

Kaneko

Ōtsuki

2016

IJN

View full text Add to dashboard Cite

Energy intake has been decreasing these ten years in Japan, and low energy intake is remarkable especially among young women. We attempted to show the dietary habits and physiological function including glucose tolerance and stamina for endurance-running in contemporary young Japanese women who take insufficient energy. 85 healthy women aged 20.5±1.1 years were enrolled in the present study. Subjects were categorized in two groups; Group I (n=70) with higher energy intake, and Group II (n=15) with lower energy intake than the basal metabolic rate (BMR). Actual energy intake in Group I was 1598.8±282.1 kcal/day, and it was 1019.9±127.1 kcal/day in Group II (p<0.01). Standard 75-g oral glucose-tolerance test was performed, and the capillary glucose value was measured at the fingertip. In Group I, glucose values at fasting, 30, 60 and 120 min were 75.0±9.1, 132.1±25.2, 120.5±27.4, 105.3±19.5 mg/dl, and those in Group II were 78.9±7.7, 155.8±26.6, 142.2±26.6, 112.3±16.0 mg/dl, respectively. The values of Group II at 30 and 60 min showed significantly high (p< 0.01). Stamina and the intake of protein in Group II were significantly lower than those in Group I (p<0.05), and muscle mass and grip strength were less in Group II than in Group I, though there was no significant difference. We indicated with these results that low skeletal muscle was considered to be responsible for the impairment of glucose regulation in Group II. This study showed that young women with low energy intake should take sufficient energy and build skeletal muscle to prevent the impairment of glucose regulation.

show abstract

Exposure to the Chinese Famine in Early Life and the Risk of Metabolic Syndrome in Adulthood

Cited by 44 publications

References 13 publications

Emotional Abuse Towards Children by Schoolteachers in Aden Governorate, Yemen: A Cross-Sectional Study

Emotional Abuse Towards Children by Schoolteachers in Aden Governorate, Yemen: A Cross-Sectional Study

Prenatal malnutrition and subsequent foetal loss risk: Evidence from the 1959-1961 Chinese famine

Low Energy Intake Impairs Glucose Regulation And Stamina In Japanese Young Women

Contact Info

Product

Resources

About