Exposure to static electric fields leads to changes in biogenic amine levels in the brains of<i>Drosophila</i>

Newland, Philip L.; Ghamdi, Mesfer S. Al; Sharkh, Suleiman M.; Aonuma, Hitoshi; Jackson, Chris

doi:10.1098/rspb.2015.1198

Cited by 20 publications

(14 citation statements)

References 48 publications

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“…It was shown, i.e., that octopamine may participate in the increase in cockroach behavioral activity induced by EMF exposure 40 . Also, another study showed that the static electric eld exposure elevated biogenic amine levels, including octopamine in the Drosophila brain 45 . The increase in motor activity after EMF exposure observed in the present study can also be associated with the octopamine level increase.…”

Section: Discussionmentioning

confidence: 98%

Electromagnetic field and TGF-β enhance the compensatory plasticity after sensory nerve injury in cockroach Periplaneta americana

Jankowska

Klimek

Valsecchi

et al. 2020

Preprint

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Recovery of function after sensory nerves injury involves compensatory plasticity, which can be observed in invertebrates. The aim of the study was the evaluation of compensatory plasticity in the cockroach (Periplaneta americana) nervous system after the sensory nerve injury and assessment of the effect of electromagnetic field exposure (EMF, 50 Hz, 7 mT) and TGF-β on this process. The bioelectrical activities of nerves (pre-and post-synaptic parts of sensory path) were recorded under wind stimulation of the cerci before and after right cercus ablation and in insects exposed to EMF and treated with TGF-β. Ablation of the right cercus caused an increase of activity of the left presynaptic part of the sensory path. Exposure to EMF and TGF-β induced an increase of activity in both parts of sensory path. This suggests strengthening effects of EMF and TGF-β on the insect ability to recognize stimuli after one cercus ablation. Data from locomotor tests proved electrophysiological results. The takeover of the function of one cercus by the second one proves the existence of compensatory plasticity in the cockroach escape system, which makes it a good model for studying compensatory plasticity. We recommend further research on EMF as a useful factor in neurorehabilitation.

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Section: Discussionmentioning

confidence: 98%

Electromagnetic field and TGF-β enhance the compensatory plasticity after sensory nerve injury in cockroach Periplaneta americana

Jankowska

Klimek

Valsecchi

et al. 2020

Preprint

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“…aegypti use visual cues to locate their host [37]. It is therefore possible that they are more aware of the electric grid [38] or are unable to pick up as many short-range cues such as thermal and water-vapour cues [39,40].…”

Section: Traps and Hlc Measure Similar Protective Effect Of Trans Uthmentioning

confidence: 99%

Comparison between the human landing catch (HLC), an exposure-free mosquito-electrocuting trap (MET) and a BG-Sentinel trap (BGS) for evaluation of transfluthrin emanator against Aedes aegypti using choice and no-choice tests in a semi-field system

Tambwe

Saddler

Kibondo

et al. 2021

Preprint

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Background The human landing catch (HLC) measures human exposure to mosquito bites and evaluates the efficacy of vector control tools. However, it may expose volunteers to potentially infected mosquitoes. The mosquito electrocuting trap (MET) and BG-Sentinel traps (BGS) represent alternative, exposure-free methods for sampling host-seeking mosquitoes. This study investigates whether these methods can be effectively used as alternatives to HLC for measuring the efficacy transfluthrin against Aedes aegypti. Methods The protective efficacy (PE) of freestanding passive transfluthrin emanators (FTPEs), measured by HLC, MET and BGS were compared in no-choice and choice tests. The methods were located 2 m from an experimental hut with FTPEs positioned 3 m on either side of them. For the choice experiment, a competitor HLC was included 10 m from the first collection point. One hundred laboratory-reared Ae. aegypti mosquitoes were released and collected for three consecutive hours. Results In the no-choice test, each method measured similar PE; HLC: 66% (95% confidence interval [CI]: 50–82), MET: 55% (95% CI: 48–63) and BGS: 64% (95% CI: 54–73). The proportion of mosquitoes recaptured was consistent between methods (20–24%) in treatment and varied (47–71%) in the control. However, in choice tests, the PE measured by each method varied; HLC: 37% (95% CI: 25–50%), MET: 76% (95% CI: 61–92) and BGS trap: 0% (95% CI: 0–100). Recaptured mosquitoes were no longer consistent between methods in treatment (2–26%) and remained variable in the control (7–42%). FTPE provided 50% PE to the second HLC 10 m away. In the control, the MET and the BGS were less efficacious in collecting mosquitoes in the presence of a second HLC. Conclusions Measurement of the PE in isolation was fairly consistent for HLC, MET and BGS. Because HLC is not advisable, it is reasonable to use MET / BGS as a proxy for HLC for testing VP in areas of active arboviruses endemic areas. The presence of a human host in close proximity invalidated the PE estimates from BGS and METs. Findings also indicated that transfluthrin can protect multiple people in the peridomestic area and that at short-range mosquitoes select humans over the BGS.

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“…After centrifugation of the homogenate at 17 000 g for 30 min at 4°C, the supernatant was collected. DA was measured using a C18 reverse phase column in a Hitachi 655A HPLC autosampler with a Coulochem M 5100A electrochemical detector (Newland et al, 2015). To control for dietary DA, we tried to detect DA in fly diet but the levels were below detection thresholds.…”

Section: Da Content Quantitationmentioning

confidence: 99%

Disruption of dopamine homeostasis has sexually dimorphic effects on senescence characteristics of Drosophila melanogaster

Bednářová

Hanna

Rakshit

et al. 2017

Eur J of Neuroscience

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The neurotransmitter dopamine (DA) is known to be involved in a multitude of physiological processes. We investigated sexually dimorphic effects of disruptions in DA homeostasis and its relationship to senescence using three different Drosophila melanogaster mutants namely Catsup (Catsup26) with elevated DA levels, and pale (ple2), Punch (PuZ22) with depleted DA levels. In all genotypes including controls, DA levels were significantly lower in old (45-50 day old) flies compared to young (3-5 day old) in both sexes. Interestingly, females had lower DA content than males at young age whereas this difference was not observed in old age, suggesting that males had a larger decline in DA levels with age. Females, in general, were longer lived compared to males in all genotypes except ple2 mutants with depleted DA levels. This phenotype was abolished in the ple2 rescue flies. Interestingly, females also demonstrated marked age-related decline in circadian locomotor activity compared to males. Old Catsup26 males with elevated DA levels accumulated significantly lower levels of lipid peroxidation product 4-hydroxy 2-nonenal (4-HNE) compared to age-matched wild type, ple2 and PuZ22 mutant males. In Catsup26 revertant lines this phenomenon was absent. We also observed a sexually dimorphic response in the expression levels of key stress and aging associated and/or related transcription factor genes across genotypes with elevated or depleted DA levels which was reverted to wild type levels in specific rescue lines. Taken together, our results reveal a novel sexually dimorphic involvement of DA in senescence characteristics of D. melanogaster.

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Exposure to static electric fields leads to changes in biogenic amine levels in the brains ofDrosophila

Cited by 20 publications

References 48 publications

Electromagnetic field and TGF-β enhance the compensatory plasticity after sensory nerve injury in cockroach Periplaneta americana

Electromagnetic field and TGF-β enhance the compensatory plasticity after sensory nerve injury in cockroach Periplaneta americana

Comparison between the human landing catch (HLC), an exposure-free mosquito-electrocuting trap (MET) and a BG-Sentinel trap (BGS) for evaluation of transfluthrin emanator against Aedes aegypti using choice and no-choice tests in a semi-field system

Disruption of dopamine homeostasis has sexually dimorphic effects on senescence characteristics of Drosophila melanogaster

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