Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway

Ding, Wenjie; Zhao, Zixuan; Zheng, Yudan; Wang, Rui; Zhang, Zeyao; Zhang, Ziyang; Wang, Xiangdong; Yu, Shali; Liu, Lei; Huang, Rongrong; Zhao, Xinyuan; Wu, Qianhui

doi:10.1016/j.ecoenv.2022.114268

Cited by 12 publications

(2 citation statements)

References 38 publications

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“…The detailed procedure was conducted as our previous description [ 22 ]. Total RNAs were extracted from mouse kidney samples by the Trizol reagent.…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Alkaline Mineral Water on Calcium Oxalate‐Induced Kidney Injury in Mice

Liu,

Lin,

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. Kidney stone disease induces chronic renal insufficiency by crystal-induced renal tubular epithelial cell injury. It has been reported that the prevalence of kidney stone disease is increasing, accompanied by the high recurrence rate. Alkaline mineral water has been reported to possess beneficial effects to attenuate inflammation. Here, we explored the potential protective effects and underlying mechanisms of alkaline mineral water against calcium oxalate-induced kidney injury. Methods. We performed the mice kidney stone model by administering glyoxylate at 100 mg/kg once daily for 7 days. To assess the effects of alkaline mineral water on oxalate-induced kidney injury, mice drank different water (distilled water, natural mineral water at pH = 8.0, as well as natural mineral water at pH = 9.3) for 7 days, respectively, followed by glyoxylate exposure. After collection, crystal formation, kidney injury and cell apoptosis, fibrosis, oxidative stress, as well as inflammation were measured. Results. Our results showed that glyoxylate treatment led to kidney crystal formation and fibrosis, which can be attenuated by drinking alkaline mineral water. Furthermore, alkaline mineral water also reduced kidney injury and cell apoptosis, oxidative stress, and inflammation. Conclusion. Alkaline mineral water supplement prevents progression of glyoxylate-induced kidney stones through alleviating oxidative stress and inflammation.

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“…The detailed procedure was conducted as our previous description [ 22 ]. Total RNAs were extracted from mouse kidney samples by the Trizol reagent.…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Alkaline Mineral Water on Calcium Oxalate‐Induced Kidney Injury in Mice

Liu,

Lin,

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…Our previous study has confirmed that SCCPs can result in astrocyte activation and inflammatory reaction via the JAK2/STAT3 signaling pathway. 13 However, it is not clear how SCCPs ingested by the digestive tract result in astrocyte activation and inflammatory reaction.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota from Short-Chain Chlorinated Paraffin-Exposed Mice Promotes Astrocyte Activation by Disrupting the Intestinal Tight Junction via Zonulin Upregulation

Zhao,

Zhang,

Zheng

et al. 2023

J. Agric. Food Chem.

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Short-chain chlorinated paraffins (SCCPs) are novel toxicants in food and are reported to possess neurotoxicity. Here, we investigated the mechanism of SCCP-induced astrocyte activation and neuroinflammation. SCCP gavage induced astrocyte activation and neuronal cell death with the changes of gut microbiome and metabolites. Antibiotic cocktail administration to deplete the gut microbiome ameliorated the astrocyte activation and inflammation induced by SCCPs. In fecal microbiota transplantation (FMT) assays, mice that received transplanted gut microbiome from SCCP-treated mice showed increased astrocyte activation and elevated inflammatory response. In addition, SCCP exposure promotes zonulin expression and tight junction injury, and antibiotic cocktail administration inhibited that in the intestinal tract. Increased zonulin and tight junction injury were also observed in SCCPs_FMT mice. The zonulin inhibition protected the tight junction in the intestinal tract from SCCP exposure and suppressed astrocyte activation. In summary, this study proposes a novel possibility for SCCP-induced astrocyte activation and neurotoxicity by the gut microbiome-mediated zonulin expression and tight junction.

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Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats

Fan,

Lin,

Luo

et al. 2024

Neurotox Res

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Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway

Cited by 12 publications

References 38 publications

Protective Effect of Alkaline Mineral Water on Calcium Oxalate‐Induced Kidney Injury in Mice

Protective Effect of Alkaline Mineral Water on Calcium Oxalate‐Induced Kidney Injury in Mice

Gut Microbiota from Short-Chain Chlorinated Paraffin-Exposed Mice Promotes Astrocyte Activation by Disrupting the Intestinal Tight Junction via Zonulin Upregulation

Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats

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