Exposure to serum perfluoroalkyl substances and biomarkers of liver function: The Korean national environmental health survey 2015–2017

Kim, Okjin; Seyoung, Kim; Park, Eun Young; Oh, Jin Kyoung; Jung, Sun Kyoung; Park, Soyoung; Hong, Sooyeon; Jeon, Hye Li; Kim, Hyun‐Jin; Bohyun, Park; Park, Sohee; Kim, Suejin; Kim, Byungmi

doi:10.1016/j.chemosphere.2023.138208

Cited by 14 publications

(11 citation statements)

References 45 publications

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“…4(b) illustrates the XPS spectra of Sn in 3d of SnO 2 , showing two distinct peaks at 487.08 and 495.48 eV for Sn 3d 5/2 and Sn 3d 3/2 states, respectively. 30 Similarly, in SnO 2 /PPS, these peaks are located at 486.78 and 495.28 eV, respectively. It should be noted here that the observed bindings energies for Sn 3d 5/2 and Sn 3d 3/2 states in SnO 2 /PPS have lower values, which could be attributed to the complexation of SnO 2 with PPS.…”

Section: Resultsmentioning

confidence: 95%

Performance and stability enhancement of perovskite photodetectors by additive and interface engineering using a dual-functional PPS zwitterion

Khan,

Kumar,

Jung

et al. 2023

Nanoscale Horiz.

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Section: Resultsmentioning

confidence: 95%

Performance and stability enhancement of perovskite photodetectors by additive and interface engineering using a dual-functional PPS zwitterion

Khan,

Kumar,

Jung

et al. 2023

Nanoscale Horiz.

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“…The results are consistent with other cross-sectional and longitudinal studies of the association of ALT with PFOA and other PFAS exposure [ 13 ]. Recent literature from the Korean NHANES adult population ( n = 1404, survey years 2015–2017) has shown that higher PFAS mixture concentrations including PFOA, PFOS, and PFNA are associated with higher ALT, as well as AST and GGT biomarker levels [ 21 ], but did not address abnormal cutoffs. It is reasonable to anticipate that more physiologic cutoffs for additional biomarkers for ALT as well as AST and GGT applied to other populations will also be consistently associated with still more abnormal results for PFOA (as well as with other PFASs associated with higher liver enzyme biomarkers) but perhaps the impact of reanalysis could be less apparent in populations with a narrower range of PFOA exposures, or in smaller populations.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated cholesterol is relevant to the discussion of hepatotoxicity because the liver is the principle organ site for the control of cholesterol homeostasis [ 16 ]. The combination of consistently higher serum cholesterol and higher biomarkers of liver damage such as aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), and especially ALT is suggests a toxicant-induced nonalcoholic fatty liver disease (NAFLD) mechanism for PFAS hepatoxicity [ 8 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Adult human evidence for an association of PFAS exposure with higher liver transaminases including ALT has been present in the human literature since 2007, and pertains to populations from North America, Europe, and the Asia-Pacific region including Japan, China, and Korea [ 1 , 21 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. The human population evidence is mostly but not entirely consistent.…”

Section: Introductionmentioning

confidence: 99%

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Perfluorooctanoic Acid (PFOA) Exposure and Abnormal Alanine Aminotransferase: Using Clinical Consensus Cutoffs Compared to Statistical Cutoffs for Abnormal Values

Ducatman

Tan

Nadeau

et al. 2023

Toxics

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Background: Per- and polyfluoroalkyl substances (PFASs) including perfluorooctanoic acid (PFOA) are ubiquitous environmental contaminants. Prior analysis in the large “C8 Health Project” population defined abnormal alanine aminotransferase (ALT) with statistically derived cutoffs (>45 IU/L in men, >34 IU/L in women). Objective: To explore the degree to which PFOA was associated with modern, clinically predictive ALT biomarker cutoffs in obese and nonobese participants, excluding those with diagnosed liver disease. Methods: We reevaluated the relationship of serum PFOA to abnormal ALT using predictive cutoff recommendations including those of the American College of Gastroenterology (ACG). Evaluations modeled lifetime cumulative exposure and measured internal PFOA exposure. Results: ACG cutoff values (≥34 IU/L for males, ≥25 IU/L for females) classified 30% of males (3815/12,672) and 21% of females (3359/15,788) above ALT cutoff values. Odds ratios (OR) for above cutoff values were consistently associated with modeled cumulative and measured serum PFOA. Linear trends were highly significant. ORs by quintile showed near monotonic increases. Trends were stronger for the overweight and obese. However, all weight classes were affected. Conclusion: Predictive cutoffs increase the OR for abnormal ALT results. Obesity increases ORs, yet association with abnormal ALT pertains to all weight classes. The results are discussed in context of current knowledge about the health implications of PFOA hepatotoxicity.

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“…The nature of these associations varied depending on factors such as sex and obesity. When considering the combined exposure to multiple PFAS, a positive relationship was observed with liver enzyme levels [98]. Recently, it was found that PAH and VOC increased non-alcoholic fatty liver disease (NAFLD) among South Korean adolescents.…”

Section: Other Reported Diseasesmentioning

confidence: 99%

Effect of Persistent Organic Pollutants on Human Health in South Korea: A Review of the Reported Diseases

Rokni,

Rezaei,

Rafieizonooz

et al. 2023

Sustainability

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Persistent organic pollutants (POPs) usually originate from human activities and have been released into the environment for several decades. They are highly resistant to natural decomposition and can accumulate in an organism’s tissues and in all environmental components. Due to their unique characteristics, they have an ability to bio-magnify and bio-accumulate in animals, through the food chain and via inhalation, severely endangering the health of people. As reported, the exposure of humans to POPs causes various health problems such as cancers, diabetes, birth defects, endocrine disruption, cardiovascular diseases and dysfunctional immune and reproductive systems. The residents of South Korea are likely to face a high risk of diseases because of the existence of POPs in the environment. For instance, South Korea’s atmosphere has been reported as a hotspot for POP pollution. Besides, South Koreans’ high amount of seafood consumption is considered another source of POPs. Therefore, this article reviews the status of POP contamination in food and the health impact of POPs in South Korea. Based on the findings, the most-reported diseases were obesity and diabetes, which positively correlated to age, food habits, body index, and level of exposure to POPs. In addition, cancer and metabolic diseases are at an alarming level. Therefore, the public health impacts of POPs need continuous assessment in South Korea over the next decade.

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Exposure to serum perfluoroalkyl substances and biomarkers of liver function: The Korean national environmental health survey 2015–2017

Cited by 14 publications

References 45 publications

Performance and stability enhancement of perovskite photodetectors by additive and interface engineering using a dual-functional PPS zwitterion

Performance and stability enhancement of perovskite photodetectors by additive and interface engineering using a dual-functional PPS zwitterion

Perfluorooctanoic Acid (PFOA) Exposure and Abnormal Alanine Aminotransferase: Using Clinical Consensus Cutoffs Compared to Statistical Cutoffs for Abnormal Values

Effect of Persistent Organic Pollutants on Human Health in South Korea: A Review of the Reported Diseases

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