Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans

Gooley, Joshua J.; Chamberlain, Kyle; Smith, Kurt A.; Khalsa, Sat Bir S.; Rajaratnam, Shanthakumar M W; Reen, Eliza Van; Zeitzer, Jamie M.; Czeisler, Charles A.; Lockley, Steven W.

doi:10.1210/jc.2010-2098

Cited by 406 publications

(225 citation statements)

References 50 publications

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“…In the PVT, with preceding DL exposure, reaction times in the morning were faster under MBL than under CTRL. These results indicate a sensitization effect of prior (low) light history, similar to the effects on melatonin suppression [21], subjective sleepiness, and melatonin secretion during the night [23,34]. Such a physiological light “sensitization” effect takes place when exposure to low-intensity light leads to a stronger response during a subsequent exposure.…”

Section: Discussionmentioning

confidence: 61%

“…Melanopic light effects comprise a variety of physiological and behavioral functions, and they vary with time of day, previous light history, exposure duration, and the spectral composition of light [13,14,15,16,17,18]. The effects of light history lead to stronger or weaker effects in response to light on the same or the next day, demonstrated by melatonin secretion, subjective alertness, and cognitive performance [19,20,21,22,23]. Nowadays, different light-emitting electronic devices are widely used (late) in the evenings, and this affects subjective sleepiness, cognitive performance, sleep, and alertness the next morning [8,24,25,26].…”

Section: Introductionmentioning

confidence: 99%

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Blue-Enriched Morning Light as a Countermeasure to Light at the Wrong Time: Effects on Cognition, Sleepiness, Sleep, and Circadian Phase

Münch

Nowozin²,

Regente³

et al. 2016

Neuropsychobiology

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Light during the day and darkness at night are crucial factors for proper entrainment of the human circadian system to the solar 24-h day. However, modern life and work styles have led to much more time spent indoors, often with lower daytime and higher evening/nighttime light intensity from electrical lighting than outdoors. Whether this has long-term consequences for human health is being currently investigated. We tested if bright blue-enriched morning light over several days could counteract the detrimental effects of inadequate daytime and evening lighting. In a seminaturalistic, within-between subject study design, 18 young participants were exposed to different lighting conditions on 3 evenings (blue-enriched, bright orange, or dim light), after exposure to 2 lighting conditions (mixed blue-enriched light and control light, for 3 days each) in the mornings. Subjective sleepiness, reaction times, salivary melatonin concentrations, and nighttime sleep were assessed. Exposure to the blue-enriched morning lighting showed acute wake-promoting effects and faster reaction times than with control lighting. Some of these effects persisted until the evening, and performance improved over several days. The magnitude of circadian phase shifts induced by combinations of 3 different evening and 2 morning lighting conditions were significantly smaller with the blue-enriched morning light. During the night, participants had longer total sleep times after orange light exposure than after blue light exposure in the evening. Our results indicate that bright blue-enriched morning light stabilizes circadian phase, and it could be an effective counterstrategy for poor lighting during the day and also light exposure at the wrong time, such as in the late evening.

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Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Blue-Enriched Morning Light as a Countermeasure to Light at the Wrong Time: Effects on Cognition, Sleepiness, Sleep, and Circadian Phase

Münch

Nowozin²,

Regente³

et al. 2016

Neuropsychobiology

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“…The circulating levels of both display robust diurnal patterns (Migeon et al 1956, Ralph et al 1971. Using the CR and FD experimental protocols, the secretion rhythms of cortisol (el-Hajj Fuleihan et al 1997, Wehr et al 2001, Aeschbach et al 2003, Scheer et al 2010) and melatonin (Dijk et al 1999, Wehr et al 2001, Cain et al 2010, Gooley et al 2011 have been shown to be under direct regulation by the circadian clock. Not surprisingly, both hormones also act as major hormonal output pathways that propagate the time signal from the SCN to various other tissues.…”

Section: Endocrine Rhythms: Clock Vs Behavioral Regulationmentioning

confidence: 99%

Interactions between endocrine and circadian systems

Tsang¹,

Barclay

Oster

2013

Journal of Molecular Endocrinology

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In most species, endogenous circadian clocks regulate 24-h rhythms of behavior and physiology. Clock disruption has been associated with decreased cognitive performance and increased propensity to develop obesity, diabetes, and cancer. Many hormonal factors show robust diurnal secretion rhythms, some of which are involved in mediating clock output from the brain to peripheral tissues. In this review, we describe the mechanisms of clock-hormone interaction in mammals, the contribution of different tissue oscillators to hormonal regulation, and how changes in circadian timing impinge on endocrine signalling and downstream processes. We further summarize recent findings suggesting that hormonal signals may feed back on circadian regulation and how this crosstalk interferes with physiological and metabolic homeostasis.

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“…Secretion of melatonin exhibits circadian rhythms and is suppressed by bright light (Burgess et al, 2001;Kubota, 2002). Even room lights such as fluorescent lamps can attenuate melatonin excretion duration at night (Harada, 2004;Gooley et al, 2011). This evening lights might include lights with high color temperature from the monitor of PC, TV-game, and mobile phone.…”

Section: Melatonin Synthesis From Serotonin Can Be Suppressed By Evenmentioning

confidence: 99%

Epidemiological Evaluation of Intervention Program to Promote Mental and Sleep Health of Sports Athletes

Harada¹,

Wada²,

Akimitsu³

et al. 2013

IJPS

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Our research group has went on several intervention programs which were applied to infants, elementary school and junior high school students and university sports-club students and also people who suffered disaster of Hanshin-Awaji Great Earthquake in 1995. All intervention programs were performed and are now going on to promote mental and physical health. The current intervention program focuses on the intervention which is based on a newly constructed series-of-leaflets for promoting sleep health entitled "Three great benefits due to 'Go to Bed Early, Get up Early and Do not Forget Breakfast!". These leaflets consist of four versions for parents of small children, athletes, women and people who suffered great disasters. In this study, we would like to focus on the results of three intervention studies to promote the athletes who are the members of succor team of Kochi University held in November of 2008), 2010 (Wada et al., submitted) and 2011 Harada et al.,. unpublished). All the three kinds of intervention seem to be effective for athletes to change their chronotype into morning-typed one, promote the sleep and mental health and finally improve their performance in playing sports.

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Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans

Cited by 406 publications

References 50 publications

Blue-Enriched Morning Light as a Countermeasure to Light at the Wrong Time: Effects on Cognition, Sleepiness, Sleep, and Circadian Phase

Blue-Enriched Morning Light as a Countermeasure to Light at the Wrong Time: Effects on Cognition, Sleepiness, Sleep, and Circadian Phase

Interactions between endocrine and circadian systems

Epidemiological Evaluation of Intervention Program to Promote Mental and Sleep Health of Sports Athletes

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