Exposure to Rifampicin Is Strongly Reduced in Patients with Tuberculosis and Type 2 Diabetes

Nijland, Hanneke M. J.; Ruslami, Rovina; Stalenhoef, Janneke E.; Nelwan, Erni Juwita; Alisjahbana, Bachti; Nelwan, R.H.H.; Ven, A.J.A.M. van der; Danusantoso, Halim; Aarnoutse, Rob E.; Crevel, Reinout van

doi:10.1086/507543

Cited by 210 publications

(161 citation statements)

References 21 publications

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“…The studies done earlier had shown a high percentage of sputum positivity and a higher rate of pulmonary TB than extra pulmonary tuberculosis in diabetic patients. 1,6,9,10 It is because glucose stimulates the mycobacterial growth 5 and uncontrolled DM is responsible for poor clinical response to anti-TB therapy 6 which also increases the susceptibility to mycobacterial growth.…”

Section: 10mentioning

confidence: 99%

Effect of Anti-tubercular Drugs and Impact of Glycemic Status in Patients with Tuberculosis and Concomitant Diabetic- Tuberculosis Patients

John¹,

George²,

Poornachary³

2017

IJOPP

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India is a key nation which is endemic and epidemic to tuberculosis and diabetes. An association between diabetes and TB is biological plausible, where diabetes impairs the immune system and making it harder for the body to fight against infection. Methodology: Patients on DOTS therapy in continuation phase of anti-TB therapy, Patients with TB and Diabetes and Patients with TB alone were included in the study. Blood samples were collected and Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG) and Glycated Hemoglobin (HbA1c) were measured to understand the glycemic status and its impact on TB treatment outcomes. Results: Our study confirms the fact that type II diabetes is a strong risk factor for tuberculosis and is associated with a slower response to TB treatment and a higher mortality rate. Incidence of TB is greatest among those with conditions impairing immunity such as DM. Diabetes impairs the immune system, making it harder for the body to fight against infection.

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Section: 10mentioning

confidence: 99%

Effect of Anti-tubercular Drugs and Impact of Glycemic Status in Patients with Tuberculosis and Concomitant Diabetic- Tuberculosis Patients

John¹,

George²,

Poornachary³

2017

IJOPP

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“…Plasma concentrations of rifampicin have been found to be twofold lower in TB patients with DM compared to those without. 23 Integration of the management of these two conditions when co-existent would clearly be beneficial to optimise outcomes.…”

Section: Dual Managementmentioning

confidence: 99%

‘The tubercular diabetic': the impact of diabetes mellitus on tuberculosis and its threat to global tuberculosis control

Bailey

Grant

2011

Clinical Medicine

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-The incidence and prevalence of diabetes mellitus (DM) is rapidly increasing across the globe. Tuberculosis (TB), meanwhile, remains a significant problem in low and middle income countries fuelled by high rates of HIV/AIDS. This article explores the long recognised but underappreciated connection between the two, revealing that DM makes a substantial contribution to the burden of incident TB around the world and may also worsen TB severity and treatment outcome. The dual management of the diseases may be challenging but must be addressed, both in low and high income settings, because the rising worldwide diabetes burden poses a threat to global TB control.

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“…[12,13] Level of rifampicin found two times lower in TB with DM patients than patients with only TB. [14] Hence, it is important to focus on proper management of DM among TB patient for better outcome.…”

Section: Resultsmentioning

confidence: 99%

Comparison of development of sputum positive pulmonary tuberculosis in controlled and uncontrolled 50 cases of diabetes mellitus

Chauhan¹,

Patel²,

Sisodia³

et al. 2017

Int J Med Sci Public Health

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Exposure to Rifampicin Is Strongly Reduced in Patients with Tuberculosis and Type 2 Diabetes

Abstract: Exposure (AUC(0-6 h)) to rifampicin was 53% lower in Indonesian patients with TB and DM, compared with patients with TB only. Patients with TB and DM who have a higher body weight may need a higher dose of rifampicin.

Cited by 210 publications

References 21 publications

Effect of Anti-tubercular Drugs and Impact of Glycemic Status in Patients with Tuberculosis and Concomitant Diabetic- Tuberculosis Patients

Effect of Anti-tubercular Drugs and Impact of Glycemic Status in Patients with Tuberculosis and Concomitant Diabetic- Tuberculosis Patients

‘The tubercular diabetic': the impact of diabetes mellitus on tuberculosis and its threat to global tuberculosis control

Comparison of development of sputum positive pulmonary tuberculosis in controlled and uncontrolled 50 cases of diabetes mellitus

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