Exposure to prenatal excess or imbalanced micronutrients leads to long‐term perturbations in one‐carbon metabolism, trimethylamine‐N‐oxide and DNA methylation in Wistar rat offspring
Gia V. Shelp,
Jianzhang Dong,
Nikolai O. Orlov
et al.
Abstract:Prenatal multivitamins, including folic acid, are commonly consumed in excess, whereas choline, an essential nutrient and an important source of labile methyl groups, is underconsumed. Here, we characterized profiles of one‐carbon metabolism and related pathways and patterns of DNA methylation in offspring exposed to excess or imbalanced micronutrients prenatally. Pregnant Wistar rats were fed either recommended 1× vitamins (RV), high 10× vitamins (HV), high 10× folic acid with recommended choline (HFolRC), or… Show more
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