Exposure to polycyclic aromatic hydrocarbon mixtures and early kidney damage in Mexican indigenous population

Flores-Ramírez, Rogelio; Ortega-Romero, Manolo; Christophe-Barbier, Olivier; Meléndez-Marmolejo, Jessica Guadalupe; Rodríguez-Aguilar, Maribel; Lee-Rangel, Héctor Aarón; León-Martínez, Lorena Díaz de

doi:10.1007/s11356-021-12388-w

Cited by 13 publications

(6 citation statements)

References 73 publications

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“…Consumption habits of some traditional elements, such as yopo, tobacco, conventional alcohol, and alcohol made from wine palm, were also analyzed. Yopo is a psychotropic preparation made from the seeds of Anadenanthera peregrina and used for ritual ceremonies, wherein communication with spiritual beings is used to solve problems, obtain food, or discover cures for illnesses of community members [ 13 ]. Depending on the use, yopo is usually mixed with other natural products, such as banana, honey, and snail.…”

Section: Resultsmentioning

confidence: 99%

“…PAHs comprise a broad group of organic pollutants that exhibit different types of metabolites resulting from their degradation. The determination of 1-OHP (a metabolite of pyrene) is one of the most widely used methodologies for the determination of PAH exposure [ 13 ]. Pyrene is non-carcinogenic but is present in most work environments with the potential release of PAHs.…”

Section: Resultsmentioning

confidence: 99%

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Genetic Instability among Hitnü People Living in Colombian Crude-Oil Exploitation Areas

Galeano-Páez

Ricardo-Caldera

Jiménez-Vidal

et al. 2022

IJERPH

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Oil exploitation, drilling, transportation, and processing in refineries produces a complex mixture of chemical compounds, including polycyclic aromatic hydrocarbons (PAHs), which may affect the health of populations living in the zone of influence of mining activities (PZOI). Thus, to better understand the effects of oil exploitation activities on cytogenetic endpoint frequency, we conducted a biomonitoring study in the Hitnü indigenous populations from eastern Colombia by using the cytokinesis micronucleus cytome assay (CBMN-cyt). PAH exposure was also measured by determine urine 1-hydroxypyrene (1-OHP) using HPLC. We also evaluated the relationship between DNA damage and 1-OHP levels in the oil exploitation area, as well as the modulating effects of community health factors, such as Chagas infection; nutritional status; and consumption of traditional hallucinogens, tobacco, and wine from traditional palms. The frequencies of the CBMN-cyt assay parameters were comparable between PZOI and Hitnü populations outside the zone of influence of mining activities (POZOI); however, a non-significant incremental trend among individuals from the PZOI for most of the DNA damage parameters was also observed. In agreement with these observations, levels of 1-OHP were also identified as a risk factor for increased MN frequency (PR = 1.20) compared to POZOI (PR = 0.7). Proximity to oil exploitation areas also constituted a risk factor for elevated frequencies of nucleoplasmic bridges (NPBs) and APOP-type cell death. Our results suggest that genetic instability and its potential effects among Hitnü individuals from PZOI and POZOI could be modulated by the combination of multiple factors, including the levels of 1-OHP in urine, malnutrition, and some traditional consumption practices.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Genetic Instability among Hitnü People Living in Colombian Crude-Oil Exploitation Areas

Galeano-Páez

Ricardo-Caldera

Jiménez-Vidal

et al. 2022

IJERPH

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“…However, as previously stated, our study may have still been limited by reverse causation due to the population already having diminished kidney function. Still, this design allowed us to obtain measurements of PAHs over time, which is important given their nonpersistence 19 and in contrast to other studies that have investigated impacts on renal function using just one spot urine measurement of PAHs [15][16][17][18] . This study represents the first exploration of serially measured PAHs in relation to kidney function and allowed for a careful examination of these biomarkers over time.…”

Section: Discussionmentioning

confidence: 99%

“…14 In contrast, two other cross-sectional studies using NHANES data found associations between urinary PAH metabolites and decreased eGFR 15 and increased albuminuria. 16 Two other cross-sectional studies among highly exposed indigenous populations in Mexico reported conflicting results: one found positive associations between PAH metabolites and kidney injury biomarkers including neutrophil gelatinase-associated lipocalin (NGAL) 17 whereas the other found no such correlation. 18 To our knowledge, no longitudinal studies have been conducted on PAH exposure in relation to renal function.…”

Section: Introductionmentioning

confidence: 99%

Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation?

Jacobson¹,

Wu²,

Liu³

et al. 2022

Kidney360

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Background: Air pollution, which results in the formation of polycyclic aromatic hydrocarbons (PAH), has been identified as a cause of renal function decline and a contributor to chronic kidney disease (CKD). However, the results of cross-sectional studies investigating personal, integrated biomarkers of PAHs have been mixed. Longitudinal studies may be better suited to evaluate environmental drivers of kidney decline. The purpose of this study was to examine associations of serially measured urinary PAH metabolites with clinical and subclinical measures of kidney function over time among children with CKD. Methods: This study was conducted among 618 participants in the CKD in Children study, a cohort study of pediatric CKD patients from the US and Canada, between 2005 and 2015. In serially collected urine samples over time, nine PAH metabolites were measured. Clinical outcomes measured annually included estimated glomerular filtration rate (eGFR), proteinuria, and blood pressure. Subclinical biomarkers of tubular injury (kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)) and oxidant stress (8-hydroxy-2'- deoxyguanosine (8-OHdG) and F2-isoprostane) were assayed in urine samples. Results: Children were followed over an average of 3.0 years (standard deviation (SD)=1.6) and 2469 study visits (mean=4.0, SD=1.6). Hydroxynaphthalene (NAP) or hydroxyphenanthrene (PHEN) metabolites were detected in >99% of samples and NAP concentrations were greater than PHEN concentrations. PHEN metabolites, driven by 3-PHEN, were associated with increased eGFR and reduced proteinuria, diastolic blood pressure z-score, and NGAL concentrations over time. However, PAH metabolites were consistently associated with increased KIM-1 and 8-OHdG concentrations. Conclusions: Among children with CKD, these findings provoke the potential explanation of reverse causation where renal function affects measured biomarker concentrations even in the setting of a longitudinal study. Additional work is needed to determine if elevated KIM-1 and 8-OHdG excretion reflects site-specific injury to the proximal tubule mediated by low-grade oxidant stress.

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“…The most abundant was determined to be 1-hydroxypyrene (Supplemental Figure 2A) through co-chromatography with a standard compound. 1-Hydroxypyrene is a human urinary metabolite of pyrene that is frequently monitored to assess PAH exposure in humans 31,32 . The most abundant peak in the Supplemental Figure 2 mass spectra was the molecule ion at m/z 290.…”

Section: Pyrenementioning

confidence: 99%

Looking For Polycyclic Aromatic Hydrocarbon Metabolizing Microorganisms In The Oral Cavity of Smokers

Tao¹,

Pavlová³

et al. 2021

Preprint

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Certain soil microbes resist and metabolize polycyclic aromatic hydrocarbons (PAHs). The same is true for certain skin microbes. Oral microbes have the potential to oxidize tobacco PAHs to increase their ability to cause cancer. We hypothesized that oral microbes that resist high levels of PAH in smokers exist and can be identified based on their resistance to PAHs. We isolated bacteria and fungi that survived long term in minimal media with PAHs as the sole carbon source from the oral cavity in 11 of 14 smokers and only 1 of 6 nonsmokers. Of bacteria genera that included species that survived harsh PAH exposure in vitro, all were found at trace levels on the oral mucosa, except for Staphylococcus and Actinomyces. Two PAH-resistant strains of Candida albicans (C. albicans) were isolated from smokers. C. albicans is found orally at high levels in tobacco users and some Candida species can metabolize PAHs. The two C. albicans strains were tested for metabolism of two model PAH substrates, pyrene and phenanthrene. The result showed that the PAH-resistant C. albicans strains did not metabolize the two PAHs. In conclusion, evidence for large scale oral microbial metabolism of tobacco PAHs by common oral microbes remains lacking.

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Exposure to polycyclic aromatic hydrocarbon mixtures and early kidney damage in Mexican indigenous population

Cited by 13 publications

References 73 publications

Genetic Instability among Hitnü People Living in Colombian Crude-Oil Exploitation Areas

Genetic Instability among Hitnü People Living in Colombian Crude-Oil Exploitation Areas

Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation?

Looking For Polycyclic Aromatic Hydrocarbon Metabolizing Microorganisms In The Oral Cavity of Smokers

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