Exposure to polychlorinated biphenyls and levels of thyroid hormones in children.

Osius, Nadia; Karmaus, Wilfried; Kruse, Hermann; Witten, Jutta

doi:10.1289/ehp.99107843

Cited by 162 publications

(91 citation statements)

References 27 publications

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“…Consistent with our results was a recent Canadian study of 149 pregnant women found a significant inverse relationship between low, environmental levels of HCB, PCB 153 and ΣPCBs in plasma and total T 3 , but no associations with free T 4 and TSH (Takser et al 2005). Likewise, inverse associations between PCBs and T 3 levels were also previously observed in the wives of Swedish fishermen (Hagmar et al 2001b) and in German schoolchildren (Osius et al 1999), while another study among Dutch women reported an inverse association with T 3 that was also accompanied by an inverse association with T 4 and a positive association with TSH (Sala et al 2001). Other studies have reported an inverse association between PCBs, and T 4 and/or a positive association between PCBs and TSH, with no association between PCBs and total T 3 (Schell et al 2004;Hagmar 2003;Persky et al 2001;Emmett et al 1988), while another reported no associations between PCBs and thyroid hormones among 160 neonates from North Carolina from 1978 to 1982 (Longnecker et al 2000).…”

Section: Discussionsupporting

confidence: 92%

“…In addition, several human studies have investigated associations between levels of these compounds in the body and thyroid hormone levels (Takser et al 2005;Schell et al 2004;Bloom et al 2003;Hagmar 2003;Pelletier et al 2002;Hagmar et al 2001a;2001b;Persky et al 2001;Sala et al 2000;Longnecker et al 2000;Osius et al 1999;Koopman-Esseboom et al 1994;Emmett et al 1988). However, study populations have differed greatly and results have not been consistent across studies.…”

Section: Introductionmentioning

confidence: 99%

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Serum PCBs, p,p′-DDE and HCB predict thyroid hormone levels in men

Meeker

Altshul²,

Hauser

2007

Environmental Research

124

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Polychlorinated biphenyls (PCBs) and some organochlorine pesticides, which continue to be measurable in a high proportion of samples from the general population, have been found to alter thyroid hormone levels in animals and humans. However, studies of these relationships in adult men are limited and results across studies have been inconsistent. In the present study, we measured serum levels of 57 PCB congeners, dichlorodiphenyldichloroethylene (p,p′-DDE, a stable metabolite of DDT), and hexachlorobenzene (HCB), as well as free T 4 , total T 3 , and TSH, in 341 adult men recruited from an infertility clinic from 2000-2003. In multivariate linear regression, there were positive associations between p,p′-DDE and both free T 4 and total T 3 , and an inverse association between p,p′-DDE and TSH. Conversely, for PCBs there was only a suggestive inverse association between PCB 153 and total T 3 when potential confounding variables were considered. However, when results were additionally adjusted for p,p′-DDE, inverse associations with T 3 were significant for PCB 138, PCB 153, sum of PCBs and three different PCB groupings, and HCB, while the positive associations between p,p′-DDE and T 3 also remained. In conclusion, serum concentrations of PCBs, p,p′-DDE and HCB were associated with circulating thyroid hormone levels in adult men.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Serum PCBs, p,p′-DDE and HCB predict thyroid hormone levels in men

Meeker

Altshul²,

Hauser

2007

Environmental Research

124

View full text Add to dashboard Cite

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“…Increase in TSH level or decrease in T3 (free or total) or total T4 have been observed in most studies (Alvarez-Pedrerol et al 2008b;Darnerud et al 2010;Herbstman et al 2008;Koopman et al 1994;Osius et al 1999), except in Matsuura et al (2001) and Dallaire et al (2009).…”

Section: Introductionmentioning

confidence: 82%

Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: The Timoun cohort study in Guadeloupe (French West Indies)

Cordier

Bouquet

Warembourg

et al. 2015

Environmental Research

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Background: Perinatal exposure to endocrine-disrupting chemicals may affect thyroid hormones homeostasis and impair brain development. Chlordecone, an organochlorine insecticide widely used in the French West Indies has known estrogenic and progestin properties, but no data is available, human or animal, on its action on thyroid hormone system. Objectives: Our aim was to evaluate the impact of perinatal exposure to chlordecone on the thyroid hormone system of a sample of infants from the Timoun mother-child cohort in Guadeloupe and their further neurodevelopment.Methods: Chlordecone was measured in cord blood and breast milk samples. Thyroid stimulating hormone (TSH), free tri-iodothyronine (FT3), free thyroxine (FT4) were determined in child blood at 3 months (n = 111). Toddlers were further assessed at 18 months using an adapted version of the Ages and Stages Questionnaire (ASQ). Results:Cord chlordecone was associated with an increase in TSH in boys, whereas postnatal exposure was associated with a decrease in FT3 overall, and in FT4 among girls. Higher TSH level at 3 months was positively associated with the ASQ score of fine motor development at 18 months among boys, but TSH did not modify the association between prenatal chlordecone exposure and poorer ASQ fine motor score. Conclusions:Perinatal exposure to chlordecone may affect TSH and thyroid hormone levels at 3 months, differently according to the sex of the infant. This disruption however did not appear to intervene in the pathway between prenatal chlordecone exposure and fine motor child development.

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“…No consistent associations with a specific thyroid hormone have been observed, although positive results of some sort have been found in several studies (Hagmar et al 2001;Koopman-Esseboom et al 1994;Osius et al 1999;Persky et al 2001). In animal experiments, PCBs decrease serum levels of thyroxine (Brouwer et al 1999).…”

Section: Endocrine Disruption As a Hypothesis In Human Studiesmentioning

confidence: 98%

An approach to assessment of endocrine disruption in the National Children's Study.

Longnecker

Bellinger

Crews

et al. 2003

Environ Health Perspect

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In this article we consider the importance of assessing endocrine disruption in a large new cohort that has been proposed, the National Children's Study (NCS). We briefly review evidence that endocrine disruption is a potentially important hypothesis for human studies and weigh the need to assess endocrine disruption in the NCS. We note the salient features of earlier, similar cohort studies that serve as reference points for the design of the NCS. Finally, we discuss features of the NCS that would allow or enhance assessment of endocrine disruption, even if endocrine disruption were not a primary hypothesis motivating the study. At this time, the evidence supporting endocrine disruption in humans with background-level exposures is not strong. Thus, a compelling rationale for the NCS will probably need to be based on core hypotheses that focus on other issues. Nonetheless, if properly designed, the NCS could serve as an excellent resource for investigating future hypotheses regarding endocrine disruption.

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Exposure to polychlorinated biphenyls and levels of thyroid hormones in children.

Cited by 162 publications

References 27 publications

Serum PCBs, p,p′-DDE and HCB predict thyroid hormone levels in men

Serum PCBs, p,p′-DDE and HCB predict thyroid hormone levels in men

Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: The Timoun cohort study in Guadeloupe (French West Indies)

An approach to assessment of endocrine disruption in the National Children's Study.

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