Exposure to PM2.5 during Pregnancy and Fetal Growth in Eastern Massachusetts, USA

Leung, Michael; Weisskopf, Marc G.; Laden, Francine; Coull, Brent A.; Modest, Anna M.; Hacker, Michele R.; Wylie, Blair J.; Wei, Yaguang; Schwartz, Joel; Papatheodorou, Stefania

doi:10.1289/ehp9824

Cited by 22 publications

(11 citation statements)

References 54 publications

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“…Yuchi et al found that road proximity was associated with incidence of Alzheimer’s disease, and this association may be partially mediated by air pollution [ 27 ]. Michael et al also reported that higher gestational exposure to PM 2.5 exposure in the first 16 wk was associated with smaller fetal growth measures, where associations were particularly strong for biparietal diameter (BPD), abdominal circumference (AC), and birth weight [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Associations between PM2.5 exposure and Alzheimer’s Disease prevalence Among elderly in eastern China

Wan

et al. 2022

Environ Health

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Background Studies showed that PM2.5 might be associated with various neurogenic diseases such as Alzheimer’s Disease (AD). However, this topic had been little studied in Zhejiang province of China. Methods In 2018, we established a cohort of AD high-risk population with 1,742 elderly aged 60 and above. In 2020, the cohort was followed up, a total of 1,545 people participated the 2 surveys. Data collection included questionnaires and basic physical examinations. The average residential exposure to PM2.5 for each participant, that in a 5-years period prior to the first survey, was estimated using a satellite-based spatial statistical model. We determined the association between PM2.5 and AD prevalence by cox proportional hazards regression model. Results This study showed that an increase in the PM2.5 level was an important associated risk factor that contributed to AD. The average PM2.5 exposure levels among the study population ranged from 32.69 μg/m3 to 39.67 μg/m3 from 2013 to 2017, which were much higher than 5 μg/m3 that specified in the WHO air quality guidelines. There was an association between PM2.5 exposure and AD, and the correlations between PM2.5 and Mini-Mental State Examination, Montreal cognitive assessment scale scores were statistically significant. An increase in the PM2.5 level by 10 μg/m3 elevated the risk of AD among residents by 2%-5% (HR model 2-model 4 = 1.02 to 1.05, CI model 2-model 4 = 1.01–1.10). The subgroups of male, with old age, with low education levels, used to work as farmers or blue-collar workers before retirement, overweight and obese were associated with a higher effect of PM2.5. Conclusions Reducing PM2.5 exposure might be a good way to prevent AD.

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Section: Discussionmentioning

confidence: 99%

Associations between PM2.5 exposure and Alzheimer’s Disease prevalence Among elderly in eastern China

Wan

et al. 2022

Environ Health

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“…Our results are consistent with four studies that have assessed the impacts of prenatal PM 2.5 exposure across averaged time windows on in utero fetal growth [ 34 , 38 – 40 ]. Leung et al assessed spatiotemporal modeled PM 2.5 exposure and fetal growth among predominately non-Hispanic white participants in Eastern Massachusetts [ 39 ]. They found average PM 2.5 from conception through 16 weeks of gestation was associated with reduced abdominal circumference measured at both < 24 weeks and 24 weeks.…”

Section: Discussionmentioning

confidence: 99%

Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort

et al. 2022

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Background It is well documented that persons of color experience disproportionate exposure to environmental contaminants, including air pollution, and have poorer pregnancy outcomes. This study assessed the critical windows of exposure to ambient air pollution on in utero fetal growth among structurally marginalized populations in urban Los Angeles. Methods Participants (N = 281) from the larger ongoing MADRES pregnancy cohort study were included in this analysis. Fetal growth outcomes were measured on average at 32 $$\pm$$ ± 2 weeks of gestation by a certified sonographer and included estimated fetal weight, abdominal circumference, head circumference, biparietal diameter and femur length. Daily ambient air pollutant concentrations were estimated for four pollutants (particulate matter less than 2.5 µm (PM2.5) and less than 10 µm (PM10) in aerodynamic diameter, nitrogen dioxide (NO2), and 8-h maximum ozone (O3)) at participant residences using inverse-distance squared spatial interpolation from ambient monitoring data. Weekly gestational averages were calculated from 12 weeks prior to conception to 32 weeks of gestation (44 total weeks), and their associations with growth outcomes were modeled using adjusted distributed lag models (DLMs). Results Participants were on average 29 years $$\pm$$ ± 6 old and predominately Hispanic (82%). We identified a significant sensitive window of PM2.5 exposure (per IQR increase of 6 $$\mathrm{\mu g}/\mathrm{m}$$ μ g / m 3) between gestational weeks 4–16 for lower estimated fetal weight $$\beta$$ β averaged4-16 = -8.7 g; 95% CI -16.7, -0.8). Exposure to PM2.5 during gestational weeks 1–23 was also significantly associated with smaller fetal abdominal circumference ($$\beta$$ β averaged1-23 = -0.6 mm; 95% CI -1.1, -0.2). Additionally, prenatal exposure to PM10 (per IQR increase of 13 $$\mathrm{\mu g}/\mathrm{m}$$ μ g / m 3) between weeks 6–15 of pregnancy was significantly associated with smaller fetal abdominal circumference ($$\beta$$ β averaged6-15 = -0.4 mm; 95% CI -0.8, -0.1). Discussion These results suggest that exposure to particulate matter in early to mid-pregnancy, but not preconception or late pregnancy, may have critical implications on fetal growth.

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“…[ 80 ]). A very recent study showed that higher exposure to PM 2.5 in the first 16 weeks of pregnancy was associated with a significantly lower birth weight among other smaller fetal growth measures [ 81 ]. These observations may have a particular resonance in the context of the early origins of COPD.…”

Section: Air Pollution As An Early Determinant Of Copdmentioning

confidence: 99%

Air pollution as an early determinant of COPD

Coll

Maître

et al. 2022

Eur Respir Rev

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COPD is a progressive and debilitating disease often diagnosed after 50 years of age, but more recent evidence suggests that its onset could originate very early on in life. In this context, exposure to air pollution appears to be a potential contributor. Although the potential role of air pollution as an early determinant of COPD is emerging, knowledge gaps still remain, including an accurate qualification of air pollutants (number of pollutants quantified and exact composition) or the “one exposure–one disease” concept, which might limit the current understanding. To fill these gaps, improvements in the field are needed, such as the use of atmosphere simulation chambers able to realistically reproduce the complexity of air pollution, consideration of the exposome, as well as improving exchanges between paediatricians and adult lung specialists to take advantage of reciprocal expertise. This review should lead to a better understanding of the current knowledge on air pollution as an early determinant of COPD, as well as identify the existing knowledge gaps and opportunities to fill them. Hopefully, this will lead to better prevention strategies to scale down the development of COPD in future generations.

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Exposure to PM2.5 during Pregnancy and Fetal Growth in Eastern Massachusetts, USA

Cited by 22 publications

References 54 publications

Associations between PM2.5 exposure and Alzheimer’s Disease prevalence Among elderly in eastern China

Associations between PM2.5 exposure and Alzheimer’s Disease prevalence Among elderly in eastern China

Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort

Air pollution as an early determinant of COPD

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