Exposure to Phthalates and Breast Cancer Risk in Northern Mexico

López‐Carrillo, Lizbeth; Hernández-Ramírez, Raúl Ulises; Calafat, Antònia M.; Torres‐Sánchez, Luisa; Galván-Portillo, Marcia; Needham, Larry L.; Ruíz-Ramos, Rubén; Cebrián, Mariano E.

doi:10.1289/ehp.0901091

Cited by 324 publications

(189 citation statements)

References 46 publications

(60 reference statements)

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…Recently Lopez-Carrillo and co-workers [68] examined the association between urinary concentrations of phthalate metabolites and breast cancer in Mexican women [68]. MEP urinary concentrations were positively associated with breast cancer.…”

Section: Thyroid Function In Childrenmentioning

confidence: 99%

Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies

Jurewicz

Hanke

2011

International Journal of Occupational Medicine and Environmental Health

251

138

View full text Add to dashboard Cite

Phthalates are a family of industrial chemicals that have been used for a variety of purposes. As the potential consequences of human exposure to phthalates have raised concerns in the general population, they have been studied in susceptible subjects such as pregnant women, infants and children. This article aims at evaluating the impact of exposure to phthalates on reproductive outcomes and children health by reviewing most recent published literature. Epidemiological studies focusing on exposure to phthalates and pregnancy outcome, genital development, semen quality, precocious puberty, thyroid function, respiratory symptoms and neurodevelopment in children for the last ten years were identified by a search of the PubMed, Medline, Ebsco, Agricola and Toxnet literature bases. The results from the presented studies suggest that there are strong and rather consistent indications that phthalates increase the risk of allergy and asthma and have an adverse impact on children's neurodevelopment reflected by quality of alertness among girls, decreased (less masculine) composite score in boys and attention deficit hyperactivity disorder. Results of few studies demonstrate negative associations between phthalate levels commonly experienced by the public and impaired sperm quality (concentration, morphology, motility). Phthalates negatively impact also on gestational age and head circumference; however, the results of the studies were not consistent. In all the reviewed studies, exposure to phthalates adversely affected the level of reproductive hormones (luteinizing hormone, free testosterone, sex hormone-binding globulin), anogenital distance and thyroid function. The urinary le vels of phthalates were significantly higher in the pubertal gynecomastia group, in serum in girls with premature thelarche and in girls with precocious puberty. Epidemiological studies, in spite of their limitations, suggest that phthalates may affect reproductive outcome and children health. Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented.

show abstract

Section: Thyroid Function In Childrenmentioning

confidence: 99%

Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies

Jurewicz

Hanke

2011

International Journal of Occupational Medicine and Environmental Health

251

138

View full text Add to dashboard Cite

show abstract

“…It has been implicated in the development of male breast cancer and may cause reproductive problems among both men and women who work in PVC fabricating operations [146,147]. Elevated breast cancer risk among women in phthalate-exposed population in northern Mexico was reported by López-Carrillo et al [148].…”

Section: Phthalatesmentioning

confidence: 93%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

View full text Add to dashboard Cite

Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well.

show abstract

“…Phthalates are associated with breast cancer risk (Lopez-Carrillo et al 2010, Hsieh et al 2012a. BBP and DBP induced EMT in R2d cells, an estrogen-responsive breast stem cell line.…”

Section: Endocrine Disruptors and Cscsmentioning

confidence: 99%

Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease

Kopras

Potluri

Bermúdez

et al. 2013

Endocrine-Related Cancer

View full text Add to dashboard Cite

Development and fate of the stem cell are regulated by extrinsic signals from the environment. Endocrine-disrupting chemicals which perturb hormonal signaling in utero and during early childhood may cause deregulation of multiple developmental processes, ranging from breakdown of stem cell niche architecture, developmental reprograming and altered stem cell fate to impaired organ and gonad development and sexual differentiation. Therefore, study of the environmental effects on stem cell integrity and normal development is a new and emerging focus for developmental biologists and cell toxicologists. When combined with new human and mouse stem cell-based models, stem cell differentiation dynamics can be studied in more biologically relevant ways. In this study, we review the current status of our understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stem cell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis.

show abstract

Exposure to Phthalates and Breast Cancer Risk in Northern Mexico

Cited by 324 publications

References 46 publications

Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies

Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease

Contact Info

Product

Resources

About