Exposure to perfluoroalkyl substances during fetal life and hospitalization for infectious disease in childhood: A study among 1,503 children from the Odense Child Cohort

Dalsager, Louise; Christensen, Nikolas I.; Halekoh, Ulrich; Timmermann, Clara Amalie Gade; Nielsen, Flemming; Kyhl, Henriette Boye; Husby, Steffen; Grandjean, Philippe; Jensen, Tina Kold; Andersen, Helle Raun

doi:10.1016/j.envint.2021.106395

Cited by 45 publications

(26 citation statements)

References 33 publications

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“…Associations between PFAA exposure and various disease states in exposed human populations have been uncovered in myriad epidemiological studies, indicating that PFAAs can induce cancer and reduce immune response. However, the results are mixed with regard to the types of immunological changes and degree of vaccine suppression [ 15 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. The findings of these epidemiological studies are strengthened when combined with toxicological evidence from experimental animals.…”

Section: Discussionmentioning

confidence: 99%

Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure

Woodlief

Vance

et al. 2021

Toxics

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Novel per- and polyfluoroalkyl substances (PFAS) were recently identified in drinking water sources throughout North Carolina. These include the perfluoroether acids (PFEAs) perfluoro-2-methoxyacetic acid (PFMOAA), perfluoro-2-methoxypropanoic acid (PFMOPrA), and perfluoro-4-methoxybutanioc acid (PFMOBA). Little toxicological data exist for these PFEAs. Therefore, the present study described signs of toxicity and immunotoxicity following oral exposure. Adult male and female C57BL/6 mice were exposed once/day for 30 days to PFMOAA (0, 0.00025, 0.025, or 2.5 mg/kg), PFMOPrA, or PFMOBA (0, 0.5, 5, or 50 mg/kg). A dose of 7.5 mg/kg of perfluorooctanoic acid (PFOA) was used as a positive control. Terminal body weights, and absolute liver, spleen, or thymus weights did not differ by dose for any compound; exposure to 50 mg/kg of PFMOBA increased relative liver weights in males. Changes in splenic cellularity were observed in males exposed to PFMOPrA and decreased numbers of B and natural killer (NK) cells were observed in males and females exposed to PFMOBA. Exposure did not alter NK cell cytotoxicity or T cell-dependent antibody responses at doses administered. Our results indicate that these “understudied” PFAS have toxicological potential but require additional investigation across endpoints and species, including humans, to understand health effects via drinking water exposure.

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Section: Discussionmentioning

confidence: 99%

Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure

Woodlief

Vance

et al. 2021

Toxics

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“…After controlling for maternal age, child age, parity, and education level, a positive association was observed between prenatal exposure to PFOS and PFOA and the frequency of fever. Dalsager et al. (2021) later conducted a similar study examining prenatal PFAS levels (at 8–16 weeks gestation) and the rate of child infectious diseases resulting in hospitalization.…”

Section: Resultsmentioning

confidence: 99%

“…Attempting to define the role of immune function by measuring occurrence of infection, length of symptoms, and hospitalization need consider controlling for known confounders and effect modifiers that may contribute to infectious disease susceptibility. Most relevant studies examined controlled for breastfeeding, age, SES and sex ( Dalsager et al., 2016 ; Dalsager et al., 2021 ; Fei et al., 2010 ) and family history was not controlled in any studies examining infectious disease outcomes ( Table 4 ). Other factors minimally explored in this literature are the roles of prenatal stress, BMI, and nutrition on immune development ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…(2017) X X X X X X X Zhu et al. (2016) X X X X X X Zhou et al., 2017b , Zhou et al., 2017a X X X X X X Zhou et al., 2017b , Zhou et al., 2017a X X X X X X X Immune Outcome: Infectious Diseases and Symptoms of Infection Dalsager et al., 2016 X X X X X X X Dalsager et al. (2021) X X X X X Fei et al.…”

Section: Discussionmentioning

confidence: 99%

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Perfluoroalkyl substances exposure and immunity, allergic response, infection, and asthma in children: review of epidemiologic studies

Holst¹,

Nayak²,

Dembek

et al. 2021

Heliyon

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Some pollutants are toxic to the immune system. For example, perfluoroalkyl acids have been associated with reduced antibody responses to vaccines, 35 increased risk in children for hospitalisation with infectious disease, 36 and increased severity of COVID19 infections. 37 Exposure to trafficrelated air pollution 38 has been associated with increased mortality from COVID19 and exposure to cadmium 39 has been associated with increased mortality from influenza.…”

Section: Immunotoxicity Of Chemicals and Implications For Communicabl...mentioning

confidence: 99%

Pollution and health: a progress update

Fuller

Landrigan

Balakrishnan

et al. 2022

The Lancet Planetary Health

898

349

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Exposure to perfluoroalkyl substances during fetal life and hospitalization for infectious disease in childhood: A study among 1,503 children from the Odense Child Cohort

Cited by 45 publications

References 33 publications

Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure

Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure

Perfluoroalkyl substances exposure and immunity, allergic response, infection, and asthma in children: review of epidemiologic studies

Pollution and health: a progress update

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