Exposure to perchlorate, nitrate and thiocyanate was associated with the prevalence of cardiovascular diseases

Wang, Long; Fu, Zhi; Zheng, Jie; Wang, Shuai; Yan, Peng; Gao, Beibei; Mo, Xuming; Liang, Ping; Huang, Jinyu

doi:10.1016/j.ecoenv.2022.113161

Cited by 12 publications

(3 citation statements)

References 25 publications

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“…The NHANES data have been used in many public health and epidemiology studies. [26][27][28][29][30][31][32] Demographic, physical examination, prescription drug (RXD) and dietary supplement (DS) use 8 , and health insurance information were extracted from NHANES for survey years 2003 -2014 (6 survey cycles). This is the same cycle used in a previous study 33 regarding DS use which allowed for comparison.…”

Section: Methodsmentioning

confidence: 99%

Assessing the Use of Prescription Drugs in Obese Respondents in the National Health and Nutrition Examination Survey

Barrett

Xing

Steidley

et al. 2021

Preprint

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IntroductionObesity is a common disease and a known risk factor for many other conditions such as hypertension, type 2 diabetes, and cancer. Treatment options for obesity include lifestyle changes, pharmacotherapy, and surgical interventions such as bariatric surgery. In this study, we examine the use of prescription drugs and dietary supplements by the individuals with obesity.MethodsWe conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) data 2003-2014. We used multivariate logistic regression to analyze the correlations of demographics and obesity status with the use of prescription drugs and dietary supplement use. We also built machine learning models to predict prescription drug and dietary supplement use using demographic data and obesity status.ResultsIndividuals with obesity are more likely to take cardiovascular agents (OR=1.265, 95% CI 1.222-1.311) and metabolic agents (OR=1.398, 95% CI 1.343-1.456) than individuals without obesity. The best performing prediction model for predicting prescription drugs had the accuracy of 74.5% and the AUROC of 0.817.ConclusionsThis study can inform clinical practice and patient education of the use of prescription drugs and dietary supplements and their correlation with obesity.

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Section: Methodsmentioning

confidence: 99%

Assessing the Use of Prescription Drugs in Obese Respondents in the National Health and Nutrition Examination Survey

Barrett

Xing

Steidley

et al. 2021

Preprint

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“…However, the beneficial roles of PNT have also been reported. For example, some studies have demonstrated that dietary nitrate might have a cardiovascular protective effect [16,17] . However, to date, no epidemiological studies have illustrated clear associations between PNT exposure and renal function in the general population.…”

Section: Introductionmentioning

confidence: 99%

Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to chronic kidney disease in the general US population, NHANES 2005–2016

et al. 2023

Chinese Medical Journal

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Background: Few studies have explored the impact of perchlorate, nitrate, and thiocyanate (PNT) on kidney function. This study aimed to evaluate the association of urinary levels of PNT with renal function as well as the prevalence of chronic kidney disease (CKD) among the general population in the United States. Methods: This analysis included data from 13,373 adults (≥20 years) from the National Health and Nutrition Examination Survey 2005 to 2016. We used multivariable linear and logistic regression, to explore the associations of urinary PNT with kidney function. Restricted cubic splines were used to assess the potentially non-linear relationships between PNT exposure and outcomes. Results: After traditional creatinine adjustment, perchlorate (P-traditional) was positively associated with estimated glomerular filtration rate (eGFR) (adjusted β: 2.75; 95% confidence interval [CI]: 2.25 to 3.26; P < 0.001), and negatively associated with urinary albumin-to-creatinine ratio (ACR) (adjusted β: −0.05; 95% CI: −0.07 to −0.02; P = 0.001) in adjusted models. After both traditional and covariate-adjusted creatinine adjustment, urinary nitrate and thiocyanate were positively associated with eGFR (all P values <0.05), and negatively associated with ACR (all P values <0.05); higher nitrate or thiocyanate was associated with a lower risk of CKD (all P values <0.001). Moreover, there were L-shaped non-linear associations between nitrate, thiocyanate, and outcomes. In the adjusted models, for quartiles of PNT, statistically significant dose–response associations were observed in most relationships. Most results were consistent in the stratified and sensitivity analyses. Conclusions: Exposures to PNT might be associated with kidney function, indicating a potential beneficial effect of environmental PNT exposure (especially nitrate and thiocyanate) on the human kidney.

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“…1,2 One such example is the nitrate (NO 3 − ) anion; it has widespread use in munitions/explosives manufacturing and chemical fertilizer preparation, 3–5 and an abundance of nitrate found in livestock as well as organic wastes 6 has led to groundwater and food supply contamination and raised public health concerns. Epidemiologic studies have associated continued NO 3 − exposure via ingestion with multiple medical issues that include spontaneous abortions in pregnant women, 7 birth defects of the central nervous system and intrauterine growth restriction in children, 8 and cardiovascular effects 9 and gastric cancer in adults. 10 According to recent World Health Organization (WHO) reports, NO 3 − concentrations in surface waters have increased significantly over the last 30–40 years, 11 emphasizing a growing need for its rapid in situ detection and prompting the United States Environmental Protection Agency (US-EPA) to set the ambient water quality limit of NO 3 − at 10 ppm.…”

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confidence: 99%

Optical sensing of aqueous nitrate anion by a platinum(ii) triimine salt based solid state material

et al. 2022

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Exposure to perchlorate, nitrate and thiocyanate was associated with the prevalence of cardiovascular diseases

Cited by 12 publications

References 25 publications

Assessing the Use of Prescription Drugs in Obese Respondents in the National Health and Nutrition Examination Survey

Assessing the Use of Prescription Drugs in Obese Respondents in the National Health and Nutrition Examination Survey

Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to chronic kidney disease in the general US population, NHANES 2005–2016

Optical sensing of aqueous nitrate anion by a platinum(ii) triimine salt based solid state material

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