2020
DOI: 10.1016/j.ecoenv.2020.110662
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Exposure to PBDE47 affects mouse oocyte quality via mitochondria dysfunction-induced oxidative stress and apoptosis

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Cited by 35 publications
(17 citation statements)
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“…Mitochondria are important organelles for oxidative phosphorylation as well as ATP production and consumption in eukaryotic cells Yang et al ( 2019a , b ). The impairment of mitochondria can induce an increase in oxidative products, which in turn can further damage the cell, and induce apoptosis Sun et al ( 2020 ). In this study, at first, the ROS upregulated the expression of Caspase8 by suppressing anti-inflammatory-related signals of the extrinsic pathway, and ROS further promoted the expression of Bak1, Bax, and Cytc signaling, which regulate the mitochondrial apoptotic pathway (Sinha et al 2013 ; Tummers and Green 2017 ).…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondria are important organelles for oxidative phosphorylation as well as ATP production and consumption in eukaryotic cells Yang et al ( 2019a , b ). The impairment of mitochondria can induce an increase in oxidative products, which in turn can further damage the cell, and induce apoptosis Sun et al ( 2020 ). In this study, at first, the ROS upregulated the expression of Caspase8 by suppressing anti-inflammatory-related signals of the extrinsic pathway, and ROS further promoted the expression of Bak1, Bax, and Cytc signaling, which regulate the mitochondrial apoptotic pathway (Sinha et al 2013 ; Tummers and Green 2017 ).…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that a reduction in cytosolic Ca 2+ levels can prevent mitochondrial fragmentation ( Pinton et al, 2001 ; Tiwari et al, 2017a ); this could explain why the defect in mitochondrial fission and fusion processes might be caused by the increase of cytosolic Ca 2+ in oocytes; however, the detailed mechanism needs to be further explored. More evidence has demonstrated that oxidative stress can induce DNA damage and early apoptosis ( Zhang et al, 2019 ; Kello et al, 2020 ; Sun et al, 2020 ; Shi et al, 2021 ), resulting in a decline in oocyte quality and fertilization. In line with previous studies ( Chaube et al, 2008 ; Tiwari et al, 2017b ), we found that oocytes exposed to HES induced the accumulation of DNA damage and the occurrence of early apoptosis, which explains HES-induced decline in mouse oocyte quality.…”
Section: Discussionmentioning
confidence: 99%
“…The production of high-quality oocytes is vital for effective animal reproduction. Several studies have shown that harmful internal and external factors can decrease oocyte quality and in turn reduce embryonic developmental competence ( Liang et al, 2017b ; Nie et al, 2019 ; Sun et al, 2020 ). The negative effects of TBTO exposure on different types of cells in different species, especially germ cells, have also been reported ( Baken et al, 2007 ; Mochida et al, 2007 ; Osman and van Loveren, 2012 , 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondria play an essential role in oocyte maturation ( Babayev and Seli, 2015 ). However, mitochondrial dysfunction leads to declines in oocyte quality and induces embryonic development failure ( Babayev and Seli, 2015 ; Liang et al, 2017b ; Nie et al, 2019 ; Sun et al, 2020 ). There is increasing evidence that overproduction of intracellular ROS can cause mitochondrial dysfunction, thus inducing oxidative stress in oocytes ( Liang et al, 2017b ; Lan et al, 2020 ; Xu et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%