Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat

Haddadi, Asma; Kessabi, Kaouthar; Boughammoura, Sana; Rhouma, Mariem Ben; Mlouka, Rania; Bannı, Mohamed; Messaoudi, Imed

doi:10.1007/s11356-021-18218-3

Cited by 40 publications

(32 citation statements)

References 59 publications

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“…In addition, estrous cycle disruption due to exposure to MPs has also been reported in female rats (Haddadi et al, 2022). PS-MPs (5 µm) led to a significant decrease in the duration of the fourth estrus cycle and reduced the duration of the metestrus phase compared to control rats (Haddadi et al, 2022). Further, the continuous exposure to PS-MPs (30 mg/kg) for 35 days impaired the follicles development, quality, and maturation of oocytes in the ovaries of mice (Liu Z. et al, 2022).…”

Section: Mps-induced Female Reproductive Toxicitymentioning

confidence: 96%

“…The combined effect of MPs with heavy metals in medaka fishes ( Oryzias melastigma ) has been shown to perturb similar changes such as irregular oocytes, partly adhesion, and empty follicle in the ovaries of female medaka ( Yan et al, 2020 ). Moreover, PS-MPs (5 µm) exposure (0.1 mg/day) for 24–26 days by oral gavage has perturbs folliculogenesis such as disrupted follicles maturation, differentiation, and increased number of atretic and cyst follicles in Wistar rats ( Haddadi et al, 2022 ). In addition, estrous cycle disruption due to exposure to MPs has also been reported in female rats ( Haddadi et al, 2022 ).…”

Section: Reproductive Toxic Effects Of Mps Exposurementioning

confidence: 99%

“…Moreover, PS-MPs (5 µm) exposure (0.1 mg/day) for 24–26 days by oral gavage has perturbs folliculogenesis such as disrupted follicles maturation, differentiation, and increased number of atretic and cyst follicles in Wistar rats ( Haddadi et al, 2022 ). In addition, estrous cycle disruption due to exposure to MPs has also been reported in female rats ( Haddadi et al, 2022 ). PS-MPs (5 µm) led to a significant decrease in the duration of the fourth estrus cycle and reduced the duration of the metestrus phase compared to control rats ( Haddadi et al, 2022 ).…”

Section: Reproductive Toxic Effects Of Mps Exposurementioning

confidence: 99%

“…Indeed, micro- and nano-particles of plastics may pose more risk to the reproductive system. Various studies have been conducted on animals in order to understand the effect of MPs on male and female fertility ( Hou B. et al, 2021 ; Haddadi et al, 2022 ; Wei et al, 2022 ). Moreover, MPs may also affect the growth of offspring when the mother is exposed for a longer duration, suggesting the detrimental effects of MPs on development and growth ( Luo et al, 2019 ; Wang et al, 2019 ; Hu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Developmental and reproductive toxic effects of exposure to microplastics: A review of associated signaling pathways

2022

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Microplastics (MPs), small pieces of plastic (∼5 mm), are released into the environment not only as a result of the decomposition of large-sized plastics but also from day-to-day use of plastic products. Chronic exposure to MPs has been attributed to harmful effects on aquatic organisms and rodents. Effects include gastrointestinal toxicity, hepatotoxicity, neurotoxicity, and reproductive and developmental toxicities. Exposure to MPs may also potentially affect human health. Herein, we reviewed the impact of MPs on male and female reproductive systems and the associated mechanisms involved in the reproductive and developmental toxicities of MPs. We performed a literature search in Google Scholar and PubMed using the following keywords: MPs and reproductive toxicity; MPs and developmental studies; MPs and infertility; MPs and aquatics; and MPs and rodents. Evidence of MPs accumulation has been reported in many organs of humans and experimental models. The harmful effects of MPs have been manifested in male and female reproductive systems of mammalian and aquatic animals, including developmental effects on gametes, embryos, and their offspring. This review describes various signaling pathways involved in MPs-associated male and female reproductive and developmental toxicities.

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Section: Mps-induced Female Reproductive Toxicitymentioning

confidence: 96%

Section: Reproductive Toxic Effects Of Mps Exposurementioning

confidence: 99%

Section: Reproductive Toxic Effects Of Mps Exposurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Developmental and reproductive toxic effects of exposure to microplastics: A review of associated signaling pathways

2022

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“…Research has shown MPs accumulation in rat’s ovaries and granulosa cells, reducing the growth of the follicles, decreasing the level of anti-Mullerian hormone [AMH] ( 99 ), estradiol, and causing an irregular estrous cycle and abnormal folliculogenesis ( 101 ). Granulosa cells are the essential somatic cells of the ovary responsible for normal ovarian development and maturation and play a significant role in folliculogenesis ( 102 ).…”

Section: Effects Of Mps Nps and Their Associated Chemicals On The Fem...mentioning

confidence: 99%

A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals

et al. 2023

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Over the years, the vaste expansion of plastic manufacturing has dramatically increased the environmental impact of microplastics [MPs] and nanoplastics [NPs], making them a threat to marine and terrestrial biota because they contain endocrine disrupting chemicals [EDCs] and other harmful compounds. MPs and NPs have deleteriouse impacts on mammalian endocrine components such as hypothalamus, pituitary, thyroid, adrenal, testes, and ovaries. MPs and NPs absorb and act as a transport medium for harmful chemicals such as bisphenols, phthalates, polybrominated diphenyl ether, polychlorinated biphenyl ether, organotin, perfluorinated compounds, dioxins, polycyclic aromatic hydrocarbons, organic contaminants, and heavy metals, which are commonly used as additives in plastic production. As the EDCs are not covalently bonded to plastics, they can easily leach into milk, water, and other liquids affecting the endocrine system of mammals upon exposure. The toxicity induced by MPs and NPs is size-dependent, as smaller particles have better absorption capacity and larger surface area, releasing more EDC and toxic chemicals. Various EDCs contained or carried by MPs and NPs share structural similarities with specific hormone receptors; hence they interfere with normal hormone receptors, altering the hormonal action of the endocrine glands. This review demonstrates size-dependent MPs’ bioaccumulation, distribution, and translocation with potential hazards to the endocrine gland. We reviewed that MPs and NPs disrupt hypothalamic-pituitary axes, including the hypothalamic-pituitary-thyroid/adrenal/testicular/ovarian axis leading to oxidative stress, reproductive toxicity, neurotoxicity, cytotoxicity, developmental abnormalities, decreased sperm quality, and immunotoxicity. The direct consequences of MPs and NPs on the thyroid, testis, and ovaries are documented. Still, studies need to be carried out to identify the direct effects of MPs and NPs on the hypothalamus, pituitary, and adrenal glands.

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The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes

Yin

2023

J of Applied Toxicology

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Microplastics (MPs) and nanoplastics (NPs) are extensively distributed in the environment. However, a comprehensive review and in‐depth discussion on the effects of MPs and NPs to reproductive capacity and transgenerational toxicity on mammals, especially on humans, is lacked. It is suggested that microplastics and nanoplastics could accumulate in mammalian reproductive organs and exert toxic effects on the reproductive system for both sexes. For males, the damage of microplastics consists of abnormal testicular and sperm structure, decreased sperm vitality, and endocrine disruption, which were caused by oxidative stress, inflammation, apoptosis of testicular cells, autophagy, abnormal cytoskeleton, and abnormal hypothalamic‐pituitary‐testicular axis. For females, the damage of microplastics includes abnormal ovary and uterus structure and endocrine disruption, which were caused by oxidative stress, inflammation, granulosa cell apoptosis, hypothalamic‐pituitary‐ovary axis abnormalities, and tissue fibrosis. For transgenerational toxicity, premature mortality existed in the rodent offspring after maternal exposure to microplastics. Among the surviving offspring, metabolic disorders, reproductive dysfunction, immune, neurodevelopmental, and cognitive disorders were detected, and these events directly correlated with transgenerational translocation of MPs and NPs. Studies on human‐derived cells or organoids demonstrated that transgenerational toxicity studies for both sexes are yet in the phase of exploring suitable experimental models, and more detailed research on the threat of MPs and NPs to human fertility is still urgently needed. Further studies will help assess the MPs and NPs threat to public fertility and reproductive health risks.

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Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat

Cited by 40 publications

References 59 publications

Developmental and reproductive toxic effects of exposure to microplastics: A review of associated signaling pathways

Developmental and reproductive toxic effects of exposure to microplastics: A review of associated signaling pathways

A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals

The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes

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