Exposure to metal fumes and circulating miRNAs in Algerian welders

Amrani, Imene; Haddam, Nahida; Garat, Anne; Allorge, Delphine; Zerimech, Farid; Schraen, Susanna; Taleb, A.; Merzouk, H.; Edmé, Jean-Louis; Lo-Guidice, Jean-Marc

doi:10.1007/s00420-019-01509-1

Cited by 12 publications

(2 citation statements)

References 39 publications

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“…The authors found that a high concentration of cotinine in urine (as a measure of maternal smoking) was associated with miR-223 in maternal and cord blood. Although there is a lack of literature data on the effect of smoking on the expression of circulating miRNAs, the existing evidence have so far shown that air pollutants [ 57 ], working conditions [ 58 , 59 ] and metal exposure [ 60 ] might affect the regulation of circulating miRNA.…”

Section: Discussionmentioning

confidence: 99%

The effects of maternal cigarette smoking on cadmium and lead levels, miRNA expression and biochemical parameters across the feto-placental unit

Sekovanić¹,

Dorotić²,

Pašalić³

et al. 2022

Heliyon

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Section: Discussionmentioning

confidence: 99%

The effects of maternal cigarette smoking on cadmium and lead levels, miRNA expression and biochemical parameters across the feto-placental unit

Sekovanić¹,

Dorotić²,

Pašalić³

et al. 2022

Heliyon

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“…It has become a significant public health concern with toxic effects in the skin, oral, digestive, hepatic, respiratory, and renal systems [219], capable of inducing carcinogenesis through both genetic and epigenetic mechanisms, as evaluated in mice [220] and human cells [221]. People highly exposed to Cr may have high concentrations in the urine associated with the expression of miR-21 and miR-155, promoting chronic kidney diseases [222]. In addition to urine, Cr has been detected in blood where it induces miR-142-3p, miR-19a-3p, and miR-19b-3p downregulation, and in contrast with upregulation of miR-941.…”

Section: Effects Of Epigenetic Toxicants In Phenotypic Transformationmentioning

confidence: 99%

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

et al. 2022

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Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characteristics such as genetics, physiology, and epigenetics. Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Some studies have confirmed that environmental factors may promote disease in individuals or subsequent progeny through epigenetic alterations. Variations in the epigenetic machinery cause a spectrum of different disorders since these mechanisms are more sensitive to the environment than the genome, due to the inherent reversible nature of the epigenetic landscape. Several epigenetic mechanisms, including modifications in DNA (e.g., methylation), histones, and noncoding RNAs can change genome expression under the exogenous influence. Notably, the role of long noncoding RNAs in epigenetic processes has not been well explored in the context of exposome-induced tumorigenesis. In the present review, our scope is to provide relevant evidence indicating that epigenetic alterations mediate those detrimental effects caused by exposure to environmental toxicants, focusing mainly on a multi-step regulation by diverse noncoding RNAs subtypes.

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