Exposure to maternal depressive symptoms in childhood and suicide-related thoughts and attempts in Canadian youth: test of effect-modifying factors

Goodday, Sarah M.; Bondy, Susan J.; Sutradhar, Rinku; Brown, Hilary K.; Rhodes, Anne E.

doi:10.1007/s00127-018-1612-0

Cited by 5 publications

(5 citation statements)

References 37 publications

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“…The timing of variables was restricted based on what was available from the NLSCY. While there was not complete overlap between the exposure and life stress variable, given that depressive symptoms were stable over the first 5 years (Goodday et al ., 2018 ), there are still instances where life stress in offspring could contribute to depressive symptoms in mothers. There are also likely other unmeasured confounders that we were unable to account for that differ by psychiatric symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Studies also support that maternal depression may be associated with offspring suicide-related behaviour in adolescence (Goodday et al ., 2017 ), although the nature of this association is understudied. In our prior work, we have shown that girls exposed to maternal depressive symptom during the first decade of life are at an increased risk of incident and recurrent suicide-related thoughts (SRT) and SA between 11 and 25 years of age (Goodday et al ., 2018 ). Hypothesised mechanisms linking maternal depression to offspring psychiatric problems in addition to or interacting with genetics surround disruptions in neuro-programming of important emotional systems during sensitive windows in childhood.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to maternal depressive symptoms in childhood and adolescent suicide-related thoughts and attempts: mediation by child psychiatric symptoms

Goodday

Bondy

Brown

et al. 2019

Epidemiol Psychiatr Sci

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Aims The nature of the association between child psychiatric symptoms and adolescent suicide-related thoughts (SRT) and attempts (SA) remains unclear. Our objective was to assess whether child psychiatric symptoms from 6 to 10 years of age mediate the association between exposure to maternal depressive symptoms in childhood and offspring SRT and SA in adolescence. Methods A population-based cohort study was constructed by linking all eight cycles from the National Longitudinal Survey of Children and Youth (NLSCY), a nationally representative Canadian panel survey conducted from 1994 to 2009. Self-reported maternal depressive symptoms were measured when offspring were between 0 and 5 years. Maternal-reported child psychiatric symptoms and psychiatric comorbid symptoms were measured from 6 to 10 years, and offspring self-reported SRT and SA were measured between 11 and 19 years. Indirect effects, the effect proportion mediated and their corresponding bootstrapped 95% confidence intervals (CI) were estimated. Results Hyperactivity and inattention significantly mediated the association between maternal depressive symptoms in childhood and risk of both SRT and SA from 11 to 19 years, where approximately 60% (SRT 95% CI 23–94%; SA 95% CI 27–95%) of this association was explained by hyperactivity and inattention. Psychiatric comorbid symptoms also significantly mediated this relationship and accounted for 50% (95% CI 18–81%) of this association with SA. Conclusions Targeting hyperactivity and inattention, and co-occurring psychiatric symptoms in offspring of depressed mothers could reduce risk of SRT, eventual SA and halt progression towards suicide. However, further understanding of comorbid psychiatric symptoms in childhood that most strongly predict adolescent SA is needed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to maternal depressive symptoms in childhood and adolescent suicide-related thoughts and attempts: mediation by child psychiatric symptoms

Goodday

Bondy

Brown

et al. 2019

Epidemiol Psychiatr Sci

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“…Further, girls—in whom we observed a statistically significant increased risk for assault in our study despite small numbers in the stratified analyses—are known to be at increased risk of child maltreatment including physical and sexual violence, and neglect 40 . A connection between parental mood disorder and risk for suicidality in older children and adolescents has also been noted 41,42 and one study using Swedish population registers also found an increased risk of suicidal behavior in offspring of parents with schizophrenia aged 12–30 years 43 …”

Section: Discussionmentioning

confidence: 90%

Accidental injury, self‐injury, and assault among children of women with schizophrenia: a population‐based cohort study

Taylor

Brown

Saunders

et al. 2021

Acta Psychiatr Scand

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We aimed to compare the risk for injury overall and by intent (accidental injury, self-injury, and assault) among children born to women with versus without schizophrenia. Methods: Using health administrative data from Ontario, Canada, children born from 2003 to 2017 to mothers with (n = 3769) and without (n = 1,830,054) schizophrenia diagnosed prior to their birth were compared on their risk for child injury, captured via emergency department, hospitalization, and vital statistics databases up to age 15 years. Cox proportional hazard models generated hazard ratios for time to first injury event (overall and by intent), adjusted for potential confounders (aHR). We stratified by child sex and age at follow-up: 0-1 (infancy), 2-5 (pre-school), 6-9 (primary school), and 10-15 (early adolescence) planning to collapse age categories as needed to obtain stable and reportable estimates. Results: Maternal schizophrenia was associated with elevated risk for child injury overall (105.4 vs. 89.4/1000 person-years (py), aHR 1.08, 95% CI 1.03-1.14), accidental injury (104.7 vs. 88.1/1000py, 1.08, 1.03-1.14), for self-injury (0.4 vs. 0.2/1000py, 2.14 1.18-3.85), and assault (1.0 vs. 0.3/1000py, 2.29, 1.45-3.62). By child sex, point estimates were of similar magnitude and direction, though not all remained statistically significant. For accidental injury and self-injury, the risk associated with maternal schizophrenia was most elevated in 10-15-year-olds. For assault, the risk associated with maternal schizophrenia was most elevated among children in the 0-1 and 2-5-year-old age groups. Conclusion:The elevated risk of child injury associated with maternal schizophrenia, especially for self-injury and assault, suggests that targeted monitoring and preventive interventions are warranted. K E Y W O R D S child, injuries, schizophrenia SUPPORTING INFORMATION Additional supporting information may be found online in the Supporting Information section. How to cite this article: Taylor CL, Brown HK, Saunders NR, et al. Accidental injury, self-injury, and assault among children of women with schizophrenia: a population-based cohort study.

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“…Of the 21 male adolescent and youth articles, 19 were epidemiological observational studies that drew from large population datasets or primary cross-sectional research. [55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73] One study utilized mixed methods, combining data from the Quebec Coroner's office and psychological autopsy interviews 74 and one comprised a prepost feasibility test of a literature based intervention. 75 Ten studies compared suicide in male and female adolescents, linking coroner data or mortality statistics with provincial health databases.…”

Section: Health Inequitiesmentioning

confidence: 99%

“…55 Ten studies explored suicidality in adolescents and youth. 56,[58][59][60][61][62][63][64]67,70 Sex differences studies indicated that suicide attempts in males occurred at a younger age (ages 11 to 13) compared to females (ages 14 to 16). 59 A population study (n ¼ 29,315; 48% males) reported that adolescent males were more likely than females to report physical violence (46% vs. 30%), and such experiences increased their odds 5-fold for making a suicide attempt; boys who experienced sexual violence were 3 times more likely than girls to make a suicide attempt.…”

Section: Health Inequitiesmentioning

confidence: 99%

Segmenting or Summing the Parts? A Scoping Review of Male Suicide Research in Canada

et al. 2021

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Objective: Suicide in Canadian men is high and rising. Research consistently indicates increased suicide risk in male subgroups including sexual minority, Indigenous, middle-aged, and military men. The current scoping review addresses the research question: Among male subgroups featured in Canadian suicide research, what are the key findings to inform suicide prevention efforts?. Method: A scoping review was undertaken in accord with PRISMA-ScR guidelines. Structured searches were conducted in CIHAHL, Medline, PsychInfo, and Web of Science to identify studies reporting suicidality (suicidal ideation, plans and/or attempts) and suicide among men in Canada. Inclusion criteria comprised primary empirical studies featuring Canadian male subgroups published in English from 2009 to 2020 inclusive. Results: Sixty-eight articles met the inclusion criteria, highlighting significant rates of male suicidality and/or suicide in 3 categories: (1) health inequities ( n = 29); (2) age-specific ( n = 30); and (3) occupation ( n = 9). The health inequities category included sexual minority men, Indigenous, and other marginalized males (i.e., homeless, immigrant men, and men who use opiates). Age-specific men focused on adolescents and youth, and middle-aged and older males. Active military, veterans, and first responders featured in the occupation category. Studies compared at risk male subgroups to females, general male populations, and/or other marginalized groups in emphasizing mental health disparities and increased suicide risk. Some men’s suboptimal connections to existing mental health care services were also highlighted. Conclusion: While male subgroups who are vulnerable to suicidality and suicide were consistently described, these insights have not translated to tailored upstream suicide prevention services for Canadian boys and men. There may be some important gains through integrating social and mental health care services for marginalized men, implementing school-based masculinity programs for adolescent males, orientating clinicians to the potential for men’s mid-life suicide risks (i.e., separation, bereavement, retirement) and lobbying employers to norm help-seeking among activate military, veterans, and first responder males.

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Exposure to maternal depressive symptoms in childhood and suicide-related thoughts and attempts in Canadian youth: test of effect-modifying factors

Cited by 5 publications

References 37 publications

Exposure to maternal depressive symptoms in childhood and adolescent suicide-related thoughts and attempts: mediation by child psychiatric symptoms

Exposure to maternal depressive symptoms in childhood and adolescent suicide-related thoughts and attempts: mediation by child psychiatric symptoms

Accidental injury, self‐injury, and assault among children of women with schizophrenia: a population‐based cohort study

Segmenting or Summing the Parts? A Scoping Review of Male Suicide Research in Canada

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