Exposure to Low (≤10 cGy) Doses of 4He Particles Leads to Increased Social Withdrawal and Loss of Executive Function Performance

Burket, Jessica A.; Matar, Mona; Fesshaye, Arriyam; Pickle, Jerrah C.; Britten, Richard A.

doi:10.1667/rade-20-00251.1

Cited by 16 publications

(15 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Self-grooming is an innate behavioral repertoire for rodent hygiene and care for the body surface ( Spruijt et al, 1992 ) and is an important endophenotype for assessing treatment effects and exploring the neural mechanisms in various psychiatric disorders ( Burket et al, 2021 ; Pinhal et al, 2018 ; Reis-Silva et al, 2019 ). As an autistic model, the Shank3B KO mouse exhibits robust self-grooming, which is considered a repetitive stereotyped behavior ( Peca et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Liu

Huang

et al. 2021

Neurobiology of Stress

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Liu

Huang

et al. 2021

Neurobiology of Stress

View full text Add to dashboard Cite

“…However, no changes were observed in misses/contacts or kinematic measures of performance upon varying reward rate (i.e., motivational component) or string length (i.e., temporal component). While these factors were not exclusively assessed in the current study, evidence for motivational and/or attention deficits have been reported following exposure to SR in various behavioral tasks, including psychomotor vigilance task [31], attentional set shifting [20, 32–35], and social withdrawal [27]. Therefore, this work taken with the current findings that 4 He rats take longer to approach the string, and both SR groups engage in longer pull durations, it is possible that irradiated rats may have experienced attentional, temporal, or motivational impairments that influenced performance in the string-pull task 72 hours after exposure.…”

Section: Discussionmentioning

confidence: 99%

Rapid loss of fine motor skills after low dose space radiation exposure

Blackwell

Fesshaye

Tidmore

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Sensorimotor function, motivation, and attentional processes are fundamental aspects of behavioral organization during skilled tasks. NASA's planned expedition to Mars will expose astronauts to space radiation that has the potential to impair performance in mission critical tasks. Impairments in task accuracy and movement kinematics have been previously reported during string-pulling behavior approximately 7 months after space radiation exposure. If similar space radiation-induced sensorimotor deficits emerge at earlier times, then astronauts may have compromised in-flight performance disruptions while performing skilled tasks in critical situations, such as when manipulating controls or performing seat egress. Due to the possibility that such performance losses may compromise mission success, it is critical to determine if performance deficits occur acutely after space radiation exposure at a time point that corresponds to in-flight performance. Male Wistar rats were thus exposed to either 10 centigray simplified galactic cosmic radiation, 10 centigray Helium, or no radiation at all (Sham), and string-pulling behavior was assessed approximately 72 hours later. Following exposure to space radiation, rats (Helium) took more time to approach the string to initiate string-pulling behavior and to pull in the string to reach the Cheerio (Helium and GCRsim) relative to Sham rats. Helium-exposed rats also exhibited a greater number of misses and less contacts relative to both Sham and GCRsim-exposed rats. Further, rats exposed to Helium demonstrated less concentrated reach endpoints with both the left and right hands compared to GCR-exposed rats. This work suggests that sensorimotor function and motivation and/or attentional processes were impaired 72 hours after Helium-radiation exposure.

show abstract

“…The dataset examined in this work is provided by the experimental lab in a tabular form. Initial findings on postirradiation data was previously published (Parihar et al, 2016;Jewell et al, 2018;Britten et al, 2020;Burket et al, 2021) but prescreen scores are specifically retrieved for this study. Data is available through Dr. Britten.…”

Section: Datamentioning

confidence: 99%

“…compound discrimination (CD) and compound discrimination reversal (CDR) after 20 cGy of 48 Ti (Hadley et al, 2016), and SD and CD after ≤15 cGy of 56 Fe or ≤10 cGy of 4 He (Jewell et al, 2018;Burket et al, 2021). These decrements and most behavioral deficits in the studies listed above are reported as a change in the irradiated cohort's test score from the corresponding nonirradiated group's score (Rabin et al, 2005(Rabin et al, , 2011(Rabin et al, , 2012(Rabin et al, , 2019(Rabin et al, , 2015Cucinotta et al, 2014;Acharya et al, 2015;Parihar et al, 2015;Cekanaviciute et al, 2018;Shukitt-hale et al, 2018;Britten et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Machine Learning Models to Predict Cognitive Impairment of Rodents Subjected to Space Radiation

Matar

Gökoğlu

Prelich

et al. 2021

Front. Syst. Neurosci.

Self Cite

View full text Add to dashboard Cite

This research uses machine-learned computational analyses to predict the cognitive performance impairment of rats induced by irradiation. The experimental data in the analyses is from a rodent model exposed to ≤15 cGy of individual galactic cosmic radiation (GCR) ions: 4He, 16O, 28Si, 48Ti, or 56Fe, expected for a Lunar or Mars mission. This work investigates rats at a subject-based level and uses performance scores taken before irradiation to predict impairment in attentional set-shifting (ATSET) data post-irradiation. Here, the worst performing rats of the control group define the impairment thresholds based on population analyses via cumulative distribution functions, leading to the labeling of impairment for each subject. A significant finding is the exhibition of a dose-dependent increasing probability of impairment for 1 to 10 cGy of 28Si or 56Fe in the simple discrimination (SD) stage of the ATSET, and for 1 to 10 cGy of 56Fe in the compound discrimination (CD) stage. On a subject-based level, implementing machine learning (ML) classifiers such as the Gaussian naïve Bayes, support vector machine, and artificial neural networks identifies rats that have a higher tendency for impairment after GCR exposure. The algorithms employ the experimental prescreen performance scores as multidimensional input features to predict each rodent’s susceptibility to cognitive impairment due to space radiation exposure. The receiver operating characteristic and the precision-recall curves of the ML models show a better prediction of impairment when 56Fe is the ion in question in both SD and CD stages. They, however, do not depict impairment due to 4He in SD and 28Si in CD, suggesting no dose-dependent impairment response in these cases. One key finding of our study is that prescreen performance scores can be used to predict the ATSET performance impairments. This result is significant to crewed space missions as it supports the potential of predicting an astronaut’s impairment in a specific task before spaceflight through the implementation of appropriately trained ML tools. Future research can focus on constructing ML ensemble methods to integrate the findings from the methodologies implemented in this study for more robust predictions of cognitive decrements due to space radiation exposure.

show abstract

Exposure to Low (≤10 cGy) Doses of 4He Particles Leads to Increased Social Withdrawal and Loss of Executive Function Performance

Cited by 16 publications

References 37 publications

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Rapid loss of fine motor skills after low dose space radiation exposure

Machine Learning Models to Predict Cognitive Impairment of Rodents Subjected to Space Radiation

Contact Info

Product

Resources

About