Exposure to light at night and risk of depression in the elderly

Obayashi, Kenji; Saeki, Keigo; Iwamoto, Junko; Ikada, Yoshito; Kurumatani, Norio

doi:10.1016/j.jad.2013.06.018

Cited by 78 publications

(57 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The enhanced statistical power of this large-scale study also detected a significant association between physiological melatonin levels and depressive symptoms, which was not statistically significant in our previous study with a smaller sample size (n ϭ 516) (28).…”

Section: Discussioncontrasting

confidence: 70%

“…Previous studies validating this cutoff value reported a sensitivity and specificity for clinically diagnosed depression of 0.85-0.91 and 0.68 -0.78, respectively (27). Some studies suggested that the cutoff value of 6 was optimal, although a cutoff value of 5, with higher sensitivity but lower specificity, was used in our previous study (28).…”

Section: Measurement Of Depressive Symptomsmentioning

confidence: 73%

See 1 more Smart Citation

Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort

Obayashi¹,

Saeki²,

Iwamoto

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 70%

Section: Measurement Of Depressive Symptomsmentioning

confidence: 73%

Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort

Obayashi¹,

Saeki²,

Iwamoto

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

View full text Add to dashboard Cite

show abstract

“…Shorter days during winter are associated with seasonal affective disorder and cognitive dysfunction in both humans and nocturnal animals, whereas bright light is an effective therapy for human patients with seasonal or non-seasonal depression 11,13,[79][80][81][82][83][84][85] . Our study showing lightdependent NT plasticity in the SCN-PeVN network is a new mechanism for seasonal adaptation that might prove useful for the development of novel targets and therapeutic approaches for treating seasonal depression and cognitive impairment induced by altered light-dark cycles.…”

Section: Discussionmentioning

confidence: 99%

Photoperiod-Induced Neurotransmitter Switching in the Circadian Pacemaker Regulates Hypothalamic Dopamine Expression

Porcu

Booreddy

Welsh

et al. 2020

Preprint

View full text Add to dashboard Cite

Light, circadian clocks, and rhythmic behaviors interact closely to produce a temporal order that is essential for the survival of most living organisms. In mammals, the principal circadian pacemaker in the brain is the suprachiasmatic nucleus (SCN), which receives direct retinal input and synchronizes itself and other brain regions to the external light-dark cycle. Altered day length (photoperiod) and disrupted circadian rhythms are associated with impaired memory and mood in both humans and animal models. Prior work demonstrated that altering photoperiod can change neurotransmitter (NT) expression in the periventricular nucleus (PeVN) of the hypothalamus in adult rat brain. Here we show that neuromedin S-(NMS-) and vasoactive intestinal polypeptide-(VIP-) expressing neurons in the SCN also display photoperiod-induced neurotransmitter switching. Such photoperiod-dependent NT plasticity is retained in Bmal1-KO mice, indicating that NT plasticity in the SCN does not require a functional circadian clock. Utilizing a conditional viral DO-DIO vector as an historical marker of NT expression in the SCN, we further reveal that short-day photoperiod induces a cluster of non-NMS-expressing neurons to undergo NT switching and acquire the NMS phenotype. Selective chemogenetic activation of NMS neurons, but not VIP neurons, during the dark phase induces a significant delay in the timing of locomotor activity onset and is sufficient to increase the number of dopaminergic neurons in the PeVN. Our findings provide novel insights into molecular adaptations of the SCN neuronal network in response to altered photoperiod that affect neuronal circuit function in the hypothalamus and lead to changes in circadian behavior.

show abstract

“…Research on natural light environments has focused on workers, university students (Hoaki et al, 2011;Smolders, de Kort, & van den Berg, 2013), older people living independently (Campbell, Kripke, Gillin, & Hrubovcak, 1988;Obayashi, Saeki, Iwamoto, Ikada, & Kurumatani, 2013), and those in care facilities (Ancoli-Israel et al, 1997;Mishima, Okawa, Shimizu, & Hishikawa, 2001;Shochat, Martin, Marler, & Ancoli-Israel, 2000). A relationship between the amount of light and mental health has been reported among home-dwelling, frail, older people (Ichimori, Tsukasaki, & Koyama, 2013;Obayashi et al, 2013), but the relationship between light and sleep remains unexamined. One previous study measured the light environment of homedwelling older people using a stationary luminometer to determine the relationship between mental health and daytime illuminance (Obayashi et al, 2013).…”

mentioning

confidence: 99%

“…A relationship between the amount of light and mental health has been reported among home-dwelling, frail, older people (Ichimori, Tsukasaki, & Koyama, 2013;Obayashi et al, 2013), but the relationship between light and sleep remains unexamined. One previous study measured the light environment of homedwelling older people using a stationary luminometer to determine the relationship between mental health and daytime illuminance (Obayashi et al, 2013). However, the relationship between sleep and illuminance in the participants' daily sleep-activity cycle remains unclear.…”

mentioning

confidence: 99%

Illuminance, Subjective Sleep Quality, and Psychosomatic Health in Elderly Individuals Requiring Care: A Survey of Japan’s Hokuriku Region in Winter

Ichimori

Tsukasaki

Emi

2015

Journal of Community Health Nursing

View full text Add to dashboard Cite

We measured the illuminance exposure for 3 days in winter of a convenience sample of 44 elderly people certified as requiring support in Japan's Hokuriku region. We calculated the illuminance ratio per minute during activity and while in bed and analyzed the relationship between illuminance, subjective sleep quality, and psychosomatic health. There was a significant negative correlation between illuminance and 15-item Geriatric Depression Scale scores. Multiple regression analysis indicated that depression scores were significantly related to age, level of required support, and illuminance. The findings suggest that environments without light and dark cycles increase depression scores in frail elderly people.

show abstract

Exposure to light at night and risk of depression in the elderly

Cited by 78 publications

References 29 publications

Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort

Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort

Photoperiod-Induced Neurotransmitter Switching in the Circadian Pacemaker Regulates Hypothalamic Dopamine Expression

Illuminance, Subjective Sleep Quality, and Psychosomatic Health in Elderly Individuals Requiring Care: A Survey of Japan’s Hokuriku Region in Winter

Contact Info

Product

Resources

About