Exposure to lead increases the risk of meningioma and brain cancer: A meta-analysis

Yan-fa, Meng; Tang, Caoli; Yu, Jun; Meng, Shiyao; Zhang, Wanying

doi:10.1016/j.jtemb.2020.126474

Cited by 34 publications

(18 citation statements)

References 30 publications

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“…The reproductive system may also lead to developmental disorders in children [ 10 – 13 ]. Lead can cross the placenta and cause damage to the developing fetal nervous system [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Construction of a sensitive and specific lead biosensor using a genetically engineered bacterial system with a luciferase gene reporter controlled by pbr and cadA promoters

et al. 2020

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Background A bacterial biosensor refers to genetically engineered bacteria that produce an assessable signal in the presence of a physical or chemical agent in the environment. Methods We have designed and evaluated a bacterial biosensor expressing a luciferase reporter gene controlled by pbr and cadA promoters in Cupriavidus metallidurans (previously termed Ralstonia metallidurans) containing the CH34 and pI258 plasmids of Staphylococcus aureus, respectively, and that can be used for the detection of heavy metals. In the present study, we have produced and evaluated biosensor plasmids designated pGL3-luc/pbr biosensor and pGL3-luc/cad biosensor, that were based on the expression of luc+ and under the control of the cad promoter and the cadC gene of S. aureus plasmid pI258 and pbr promoter and pbrR gene from plasmid pMOL30 of Cupriavidus metallidurans. Results We found that the pGL3-luc/pbr biosensor may be used to measure lead concentrations between 1–100 μM in the presence of other metals, including zinc, cadmium, tin and nickel. The latter metals did not result in any significant signal. The pGL3-luc/cad biosensor could detect lead concentrations between 10 nM to 10 μM. Conclusions This biosensor was found to be specific for measuring lead ions in both environmental and biological samples.

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“…The reproductive system may also lead to developmental disorders in children [ 10 – 13 ]. Lead can cross the placenta and cause damage to the developing fetal nervous system [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Construction of a sensitive and specific lead biosensor using a genetically engineered bacterial system with a luciferase gene reporter controlled by pbr and cadA promoters

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The reproductive system may also lead to developmental disorders in children [10]. Lead can cross the placenta and cause damage to the developing fetal nervous system [11].…”

Section: Introductionmentioning

confidence: 99%

Construction of a sensitive and specific lead biosensor using a genetically engineered bacterial system with a luciferase gene reporter controlled by pbr and cadA promoters

Nourmohammadi

Hosseinkhani

Khoshdel‐Sarkarizi

et al. 2020

Preprint

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Background: A bacterial biosensor refers to genetically engineered bacteria that produce an assessable signal in the presence of a physical or chemical agent in the environment.Methods: We have designed and evaluated a bacterial biosensor expressing a luciferase-reporter gene controlled by pbr and cadA promoters in Cupriavidus metallidurans (previously termed Ralstonia metallidurans ) containing the CH34 and pI258 plasmids of Staphylococcus aureus , respectively, and that can be used for the detection of heavy metals. In the present study, we have produced and evaluated biosensor plasmids designated pGL3-luc/pbr -biosensor and pGL3-luc/cad -biosensor, that were based on the expression of luc+ under the control of the cad promoter and the cadC gene of S. aureus plasmid pI258 and pbr promoter and pbrR gene from plasmid pMOL30 of Cupriavidus metallidurans.Results: We found that the pGL3-luc/pbr -biosensor may be used to measure lead concentrations between 1-100 μM in the presence of other metals, including: zinc, cadmium, tin and nickel. The latter metals did not result in any significant signal gene expression of the reporter . The pGL3-luc/cad -biosensor could detect lead concentrations between 10 nM to 10 μM.Conclusions: This biosensor was found to be a specific for measuring lead ions in both environmental and biological samples.

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“…The reproductive system may also be affected by developmental disorders that are highly likely to occur in children [10][11][12][13]. Lead can cross the placenta and cause damage to the developing fetal nervous system [14].…”

Section: Introductionmentioning

confidence: 99%

Construction of a sensitive and specific lead biosensor using a genetically engineered bacterial system with a luciferase gene reporter

Nourmohammadi

Hosseinkhani

Khoshdel‐Sarkarizi

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: A bacterial biosensor refers to genetically engineered bacteria that produce an assessable signal in the presence of a physical or chemical agent in the environment. Methods: We have designed and evaluated a bacterial biosensor expressing a luciferase-reporter gene controlled by pbr and cadA promoters in Cupriavidus metallidurans (previously termed Ralstonia metallidurans) containing CH34 and pI258 plasmids of Staphylococcus aureus, respectively, and that can be used for the detection of heavy metals. In the present study, we produced biosensor plasmids designated pGL3-luc/pbr-biosensor and pGL3-luc/cad-biosensor, that were based on the expression of luc+ under the control of the cad promoter and the cadC gene of S. aureus plasmid pI258 and pbr promoter and pbrR gene from plasmid pMOL30 of Cupriavidus metallidurans.Results: We found that the biodegradable pGL3-luc/pbr-biosensor could be used to measure lead concentrations between 1-100 μM in the presence of other metals, including: zinc, cadmium, tin and nickel. The latter metals did not result in gene expression of the reporter. The pGL3-luc/cad-biosensor was able to detect lead concentrations between 10 nM to 10 μM.Conclusions: This biosensor was found to be a specific for measuring lead ions in both environmental and biological samples.

show abstract

Exposure to lead increases the risk of meningioma and brain cancer: A meta-analysis

Cited by 34 publications

References 30 publications

Construction of a sensitive and specific lead biosensor using a genetically engineered bacterial system with a luciferase gene reporter controlled by pbr and cadA promoters

Construction of a sensitive and specific lead biosensor using a genetically engineered bacterial system with a luciferase gene reporter controlled by pbr and cadA promoters

Construction of a sensitive and specific lead biosensor using a genetically engineered bacterial system with a luciferase gene reporter controlled by pbr and cadA promoters

Construction of a sensitive and specific lead biosensor using a genetically engineered bacterial system with a luciferase gene reporter

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