Exposure to isoflavone-containing soy products and endothelial function: A Bayesian meta-analysis of randomized controlled trials

Beavers, Daniel P.; Beavers, Kristen M.; Miller, Michael; Stamey, James D.; Messina, Mark

doi:10.1016/j.numecd.2010.05.007

Cited by 77 publications

(48 citation statements)

References 57 publications

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“…The alternative medical systems category included homeopathic treatment 18 , acupuncture [19][20][21] , traditional healers, naturopathy, and ayurveda 22 . The biologically based category included non-vitamin, non-mineral, natural products; diet-based therapies; and chelation therapy [23][24][25][26][27][28][29][30][31][32] . The manipulative and body-based category included chiropractic or osteopathic manipulation, massage, and movement therapies 33,34 .…”

Section: Methods Data Sourcementioning

confidence: 99%

Use of Complementary and Alternative Medicine and Self-Rated Health Status: Results from a National Survey

et al. 2010

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BACKGROUND: Despite the absence of conclusive evidence of effectiveness, complementary and alternative medicine (CAM) is used by 4 of 10 adults in the US; little is known about the association between CAM use and health status. OBJECTIVE: To determine the relation between CAM use and self-reported health status and health improvement over time. DESIGN AND PARTICIPANTS:We performed a secondary database analysis using data from the 2007 National Health Interview Survey of non-institutionalized US residents conducted by the National Center of Health Statistics of the Center for Disease Control. We identified CAM users and compared them to non-users. We used multivariable logistic regression to model the health status of respondents. We controlled for confounders including socio-demographic, clinical, and behavioral factors. The models were evaluated for discrimination and calibration. MAIN MEASURES: The likelihood of respondents to report 'Excellent' current health and 'Better' health than in the prior year. KEY RESULTS: Based on 23,393 respondents, we found 37% of U.S. adults used complementary and alternative medicine and 63% did not use any CAM. Compared to those who did not use CAM, CAM users were more likely to rate their health as 'Excellent' (adjusted-odds ratio (AOR) = 1.14, 95% CI = [1.03,1.26]). Similarly, CAM users were more likely to report their health as 'Better' than in the prior year (AOR = 1.64, 95% CI = [1.49,1.83]). The c-statistics for the two models were 0.755 and 0.616, respectively. CONCLUSION: We found a significant association between CAM use and self-rated excellent health and health improvement over the prior year. Prospective trials are required to determine whether CAM use is causally related to excellent health status and better health than in the prior year.

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Section: Methods Data Sourcementioning

confidence: 99%

Use of Complementary and Alternative Medicine and Self-Rated Health Status: Results from a National Survey

et al. 2010

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“…Celle-ci est considérée comme un indicateur du risque de maladie cardiovasculaire, car les cellules endothéliales jouent un rôle important dans l'inhibition du développement de l'artériosclérose. Une méta-analyse récente (Beavers, 2012) a montré que les isoflavones de soja (doses allant de 50 à 100 mg par jour) amélioraient considérablement la fonction endothéliale chez les femmes ménopausées.…”

Section: Les Aliments Au Soja Et La Santé Cardiovasculaireunclassified

Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé

Chevalier¹,

Debeuf²,

Joubrel³

et al. 2016

OCL

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Résumé -Aujourd'hui, 4 Français sur 10 consomment des aliments au soja. Les consommateurs les ont intégrés dans leur alimentation, sans bouleverser leurs habitudes alimentaires, parce qu'ils les considèrent naturels et sains. Les non consommateurs sont en attente de plus d'informations (origine géographique du soja et qualités nutritionnelles). La consommation est assez récente et devrait progresser dans les prochaines années. Les aliments élaborés à partir de la graine de soja fournissent des protéines de très bonne qualité nutritionnelle, des acides gras insaturés, des fibres, des vitamines et des minéraux. La graine de soja contient des isoflavones, dont une grande partie est éliminée lors de l'élaboration des aliments au soja (qui en contiennent 1 à 3 mg/g de protéine). La consommation actuelle d'aliments au soja est largement compatible avec l'apport maximal de 1mg/kg/j recommandé par l'Afssa en 2005. Le développement infantile avec les préparations à base de protéines de soja est comparable à celui observé avec celles à base de protéines de lait de vache ou avec le lait maternel, sur tous les paramètres étudiés (croissance, santé osseuse et fonctions métaboliques, reproductives, endocrines, immunitaires et neurologiques). Les aliments au soja semblent exercer un effet protecteur vis-à-vis du risque de cancer du sein (probablement lié aux isoflavones), surtout si la consommation est débutée avant l'adolescence. Chez les femmes ayant des antécédents de cancer du sein, l'alimentation peut intégrer les aliments au soja. Introduire des aliments à base de soja dans l'alimentation contribue aussi à maintenir la santé cardiovasculaire, du fait de leur effet favorable sur le taux de LDL-cholestérol, sur la fonction endothéliale, et potentiellement sur la tension artérielle. Mots clés :Alimentation / soja / consommation / nutrition / santé Abstract -Soyfoods: consumption in France, nutritional qualities and recent scientific data on its contribution to health. Today, 4 French people out of 10 eat soyfoods. Consumers have adopted them in their diet, without changing their habits, because they consider them natural and healthy. The non-users are waiting for more information (geographical origin, nutritional benefits). The consumption is relatively new and is expected to grow in the coming years. Soyfoods produced from soybeans provide high quality proteins, unsaturated fatty acids, fibres, vitamins and minerals. Soybeans contain isoflavones, much of which is lost during the production of soyfoods, which contain between 1 and 3 mg per g protein. The current consumption of soyfoods is largely consistent with the maximum intake of 1 mg/kg/day recommended by the Afssa in 2005. Infant development with formulas based on soy protein is similar to that observed with those based on cow milk or with breast milk, on all studied parameters (growth, bone health and metabolic, reproductive, endocrine, immune and neurological functions). Soyfoods may have a protective effect against the risk for breast cancer (probably due to isofla...

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“…A previous meta-analysis indicated that isoflavone phytoestrogens decreased plasma cholesterol concentrations in subjects with initially elevated levels, but had little effect on subjects with normal serum cholesterol concentrations (37). These substances may also exert beneficial effects on arterial endothelial function, which was also confirmed by Beavers et al (38). In addition to these potentially antiatherogenic effects, numerous laboratories are investigating other possible mechanisms, including the antioxidant and antiproliferative properties of these substances (39).…”

Section: Effects Of Soy Isoflavones On Coronary Heart Diseasementioning

confidence: 64%

Soy isoflavone: The multipurpose phytochemical (Review)

Wang¹,

Ge²,

Tian

et al. 2013

Biomedical Reports

143

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Abstract. Soy isoflavones are compounds found in soybean and soybean products. They have been reported to possess numerous physiological properties, such as antitumor, antimenopausal (female) osteoporosis and anti-aging. They have also been reported to improve learning and memory skills in menopausal women and aid in the prevention and treatment of heart disease, diabetes and Kawasaki disease (KD). In this review, the effects of soy isoflavones on various diseases were analyzed. Based on the analysis, it was hypothesized that the function of soybean isoflavones in the prevention and treatment of various diseases results from their phytoestrogen and antioxidant properties. However, due to their phytoestrogen properties, it is recommended that the risks of soy isoflavone intake as food and̸or medical treatment be further evaluated.

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Exposure to isoflavone-containing soy products and endothelial function: A Bayesian meta-analysis of randomized controlled trials

Cited by 77 publications

References 57 publications

Use of Complementary and Alternative Medicine and Self-Rated Health Status: Results from a National Survey

Use of Complementary and Alternative Medicine and Self-Rated Health Status: Results from a National Survey

Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé

Soy isoflavone: The multipurpose phytochemical (Review)

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