Exposure to indoor mould and children's respiratory health in the PATY study

Antova, T; Pattenden, Sam; Brunekreef, Bert; Heinrich, Joachim; Rudnai, Péter; Forastiére, Francesco; Luttmann‐Gibson, Heike; Grize, Leticia; Katsnelson, Boris A.; Moshammer, Hanns; Nikiforov, B; Šlachtová, Hana; Slotova, Katarina; Złotkowska, Renata; Fletcher, Tony

doi:10.1136/jech.2007.065896

Cited by 99 publications

(71 citation statements)

References 36 publications

(23 reference statements)

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“…The Pollution and the Young (PATY) study reported a significantly increased risk for hay fever in 6-12-yr-old children when exposed to visible mould at home [15]. Two Asian studies from Singapore also reported higher risks for rhinitis and rhinoconjunctivitis among 1-12-yr-old children [25,65].…”

Section: Allergic Rhinitismentioning

confidence: 82%

“…DIJKSTRA [29] DALES [16] DALES [32] PONSONBY [18] ZHENG [27] CHEN [25] FREEMAN [20] FREEMAN substudy [20] SPENGLER [19] PEKKANEN [33] DONG [17] DONG [22] ANTOVA [15] WARMAN [24] Summary (OR FAGBULE [34] VERHOEFF [31] LI [26] LI [35] MAIER [28] BRUNEKREEF [23] BRUNEKREEF [23] BRUNEKREEF [21] STRACHAN [37] STRACHAN [38] DIJKSTRA [29] DALES [16] SPENGLER [19] EMENIUS [36] ALPER [39] DONG [17] DONG [22] ANTOVA [15] ROSENBAUM [43] IOSSIFOVA [8] KARVONEN [42] Summary (OR LI [26] MAIER [28] BRUNEKREEF [23] BRUNEKREEF [23] CHEN [25] BIAGINI [45] IBARGOYEN-ROTETA [44] KOSKINEN substudy [47] KOSKINEN [47] LI [26] LI [35] BRUNEKREEF [21] DONG …”

Section: Discussionmentioning

confidence: 99%

“…ANTOVA et al [15] observed an increased risk of sensitisation against inhalant allergens in a pooled analysis of .58,000 children. In a smaller German study of 1,235 children, exposure to visible mould was found to increase the risk of sensitisation against mugwort, dust mites and cat (assessed by skin-prick test) among 5-7-yr-old children [68].…”

Section: Atopic Sensitisationmentioning

confidence: 99%

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Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Tischer¹,

Cm²,

Heinrich³

2011

European Respiratory Journal

144

108

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Critical reviews over the past 10 yrs have found increased respiratory and allergic health outcomes for children living in damp and mouldy environments. However, recent studies have suggested that early childhood exposure to specific mould components may actually protect children from developing allergy.We conducted a systematic review of observational studies published in English from January 1980 to July 2010. This review was conducted according to systematic guidelines for Metaanalyses of Observational Studies in Epidemiology (MOOSE). The literature was searched using a computerised bibliographic database, PubMed. In order to increase the quality of the reviewed studies, meta-analyses of the effects of visible mould exposure on allergic health outcomes were performed and we evaluated the findings according to the Bradford Hill criteria for evidence of causation.The literature search identified 1,398 peer-reviewed scientific publications, and 61 studies that fulfilled the inclusion criteria were included in this review. We observed increased risks of allergic respiratory health outcomes in children exposed to visible mould and mould spores. These findings were confirmed by the results of the meta-analysis and in line with the evaluation criteria according to Bradford Hill. Visible mould was positively associated with asthma (OR 1.49 (95% CI 1.28-1.72)), wheeze (OR 1.68 (95% CI 1.48-1.90)) and allergic rhinitis (OR 1.39 (95% CI 1.28-1.51)). However, there was a tendency of lower risk for allergic health outcomes in children exposed to mouldderived components such as (1,3)-b-D-glucan and extracellular polysaccharides.These findings suggest that home environments with visible mould and mould spore exposure increase the risk of allergic respiratory health outcomes in children. However, further investigations are needed to examine the effects of exposure to mould-derived components as the current literature is inconclusive. In order to disentangle the different effects of overall microbial exposure on children's health, research should focus on specific microbial markers in the home, in combination with new assessment techniques including molecular methods.

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Section: Allergic Rhinitismentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Atopic Sensitisationmentioning

confidence: 99%

See 1 more Smart Citation

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Tischer¹,

Cm²,

Heinrich³

2011

European Respiratory Journal

144

108

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis demonstrated that living in a humid environment is related to a significant risk of developing de novo asthma and decreasing asthma control in asthmatic patients [24]. Such conclusions have also been reached in a large European collaborative epidemiological survey [25]. Exposure to hydrophilic moulds seems to present a greater health hazard than exposure to mesophilic moulds [26].…”

Section: Current Achievementsmentioning

confidence: 69%

Environmental home inspection services in Western Europe

Charpin

Baden

Bex³

et al. 2010

Environ Health Prev Med

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This review deals with environmental home inspection services in Western Europe provided for patients at the request of attending physicians to improve patient management. Such requests are usually motivated by respiratory or general symptoms which occur or worsen at home. The visit includes a standardised questionnaire as well as environmental sampling such as mite-allergen measurement, mould identification and volatile organic compound (VOC) measurements. Besides, some nonrespiratory indoor risks are also taken into account. Following the visit, a report is sent to the family and the attending physician. These services have been developed since the early 1990s, but evaluation of their efficacy is still limited. Some studies have demonstrated a reduction in mite-allergen levels and clinical improvement following the visit and implementation of advice provided to the family. However, more studies are needed to further document efficacy and also perform cost-benefit analysis of these services.

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“…En este tema, diversos estudios han demostrado la asociación de contaminantes domiciliares, como hongos, ácaros, cucarachas, combustibles de biomasa y humo de cigarrillo, entre otros, con la presencia de morbilidad respiratoria, especialmente en niños, que permanecen la mayor parte del tiempo en sus casas (25)(26)(27)(28)(29)(30)(31)(32).…”

Section: Discussionunclassified

Prevalencia de síntomas respiratorios indicativos de asma y asociación con contaminación atmosférica en preescolares de Bucaramanga, Colombia

et al. 2010

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Introducción. Actualmente se sabe que el incremento de los niveles de contaminación atmosférica externa e interna se asocia con efectos nocivos para la salud, especialmente asma y otras alergias. Objetivos. Determinar la prevalencia de síntomas respiratorios indicativos de asma en la población preescolar y compararla entre zonas con diferentes niveles de contaminación atmosférica en Bucaramanga, Colombia. Materiales y métodos. Estudio observacional analítico de corte transversal que compara los síntomas respiratorios en menores de siete años de dos zonas de la ciudad con niveles diferentes de contaminación por material sólido en partículas y ozono. La morbilidad fue medida con un cuestionario sobre síntomas respiratorios indicativos de asma, validado al español.Resultados. Se estudiaron 768 niños distribuidos de las zonas de alta y baja contaminación. El uso de cigarrillos (27,5%) y aerosoles (22,7%) se encontraron como las fuentes de contaminación más frecuentes dentro de las viviendas. La prevalencia de ruidos respiratorios a lo largo de la vida fue de 25,6% (IC95% 23,2-29,8) y la de diagnóstico médico de asma fue de 8,4% (IC95% 6,2-11,5), sin diferencias significativas entre las zonas. El modelo final no mostró asociación entre la contaminación atmosférica y la presencia de síntomas respiratorios indicativos de asma. Por el contrario, la presencia de pisos de cemento y moho mostró una asociación significativa con estos síntomas. Conclusiones. Es posible que en Bucaramanga los factores de contaminación domiciliaria puedan tener un mayor efecto sobre la presencia de síntomas respiratorios indicativos de asma en menores de siete años que los contaminantes externos.Palabras clave: signos y síntomas respiratorios, asma/epidemiología, contaminación del aire, preescolar. Respiratory symptoms associated with asthma prevalence and air pollution in preschool childrenIntroduction. Increases in the air pollution levels has well-documented harmful effects on human health, especially exacerbating problems of asthma and other allergies. Objective. The prevalence of symptoms associated with asthma was determined in preschool populations in zones with differing levels of air pollution. Materials and methods. A cross-sectional study was conducted in Bucaramanga, Colombia, comparing respiratory symptoms in 768 children under seven years in two urban zones with different pollution levels of particulate matter and ozone. Morbidity was evaluated for respiratory indicators of asthma by means of a questionnaire version previously validated in Spanish. Results. The use of cigarettes (27.5%) and aerosols (22.7%) were the most frequent source of indoor air pollution. Wheezing prevalence was 25.6% (95% CI 23.2-29.8%) and diagnosis of asthma was 8.4% (95% CI 6.2-11.5%), with no differences between zones. The final multivariate model did not show an association between outdoor pollution and symptoms related with asthma. However, concrete flooring and presence of mold did show an association with these symptoms. Conclusions. Indoor air qua...

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Exposure to indoor mould and children's respiratory health in the PATY study

Abstract: Indoor mould exposure was consistently associated with adverse respiratory health outcomes in children living in these diverse countries.

Cited by 99 publications

References 36 publications

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Environmental home inspection services in Western Europe

Prevalencia de síntomas respiratorios indicativos de asma y asociación con contaminación atmosférica en preescolares de Bucaramanga, Colombia

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