Exposure to hypomagnetic field space for multiple generations causes amnesia in Drosophila melanogaster

Zhang, Bin; Lu, Huimin; Wang, Xi; Zhou, Xianju; Xu, Shiyu; Zhang, Ke; Jiang, Jun; Li, Yan; Guo, Aike

doi:10.1016/j.neulet.2004.08.072

Cited by 54 publications

(35 citation statements)

References 20 publications

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“…Fruit flies learned the magnetic position of the source of light that attracted them. In spite of the fact that other diverse experimental approaches were published (AcostaAvalos et al, 2001;Banks and Srygley, 2003;Camlitepe et al, 2005;Etheredge et al, 1999;Perez et al, 1999;Srygley et al, 2006;Ugolini, 2006;Vácha and Soukopová, 2004;Zhang et A relatively simple all-laboratory behavioural assay of insect magnetoreception has been developed. We found non-conditioned reactions of American cockroach to the periodical shifts of the geomagnetic field.…”

Section: Introductionmentioning

confidence: 99%

Laboratory behavioural assay of insect magnetoreception:magnetosensitivity of Periplaneta americana

Vácha

2006

Journal of Experimental Biology

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SUMMARY A relatively simple all-laboratory behavioural assay of insect magnetoreception has been developed. We found non-conditioned reactions of American cockroach to the periodical shifts of the geomagnetic field. The movement activity of animals individually placed into Petri dishes was scored as a number of body turns. Test groups were exposed to a 90-min interval with the horizontal component of the geomagnetic field periodically rotated by 60° back and forth with 5 min periodicity. The number of body turns was compared with the preceding and following intervals and with the corresponding interval of the control group kept in the natural field. We obtained a significant increase in activity when changes in field were applied. Interestingly, the period of increased activity did not coincide precisely with the 90 min stimulation interval. The onset of animal restlessness was delayed by tens of minutes and persisted correspondingly after the stimulation stopped. A respective evaluation criterion was suggested and verified. Owing to its simplicity and minimal manipulation of the insects, together with low demands on the memory and motivation state of animals, the approach potentially may be used as a laboratory diagnostic tool indicating magnetoreception in insect neurophysiology research.

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Section: Introductionmentioning

confidence: 99%

Laboratory behavioural assay of insect magnetoreception:magnetosensitivity of Periplaneta americana

Vácha

2006

Journal of Experimental Biology

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“…Previously, the HMF exposure has been found to cause abnormal cognitive behaviors and disrupt embryonic development (Wang et al 2002; Zhang et al 2004; Asashima and Shimada 1991; Mo et al 2012b; Fesenko et al 2010), but the potential biological mechanism is rarely been investigated. The proliferation, differentiation, and quiescence of NPCs/NSCs are under strict control and kept in delicate balance in embryonic as well as in adult brains (Simons and Clevers 2011; Stine and Matunis 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, the growth of the HMF-exposed NSs dropped to the same level as the GMF controls when they returned to the GMF condition; the reversible HMF effect on NS growth is consistent with the previously reported HMF effects on animal behavior. HMF-induced (10 generations of continuous HMF exposure) amnesia in Drosophila has been shown to be recoverable after six consecutive generations in the GMF (Zhang et al 2004). Since HMF is one of the environmental factors of outer space, GMF recovery would be a good option to minimize the HMF-related health risks to astronauts participating with long-term and long-distance space missions (Mo et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…It has been established that the elimination of the GMF has adverse effects on living systems (Mo et al 2012a). Animals continuously exposed to the HMF condition by shielding or compensatively eliminating the GMF exhibited dysfunction of central nervous system (CNS), with symptoms such as disturbed vocal behavior and circadian activity rhythm in birds (Bliss and Heppner 1976; Jiang et al 1998); amnesia in chicken (Wang et al 2002) and Drosophila (Zhang et al 2004); and decreased general activity, altered circadian drinking rhythm and analgesia in mice (Prato et al 2005; Mo et al 2015). The HMF also markedly disturbs development processes, evidenced by delayed embryonic and nymphal development in planthoppers (Wan et al 2014), increased embryo malformation in newt (Asashima and Shimada 1991) and Xenopus (Mo et al 2012b), as well as inhibited early embryogenesis in mice (Fesenko et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells

Liu

et al. 2016

Protein Cell

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Living organisms are exposed to the geomagnetic field (GMF) throughout their lifespan. Elimination of the GMF, resulting in a hypogeomagnetic field (HMF), leads to central nervous system dysfunction and abnormal development in animals. However, the cellular mechanisms underlying these effects have not been identified so far. Here, we show that exposure to an HMF (<200 nT), produced by a magnetic field shielding chamber, promotes the proliferation of neural progenitor/stem cells (NPCs/NSCs) from C57BL/6 mice. Following seven-day HMF-exposure, the primary neurospheres (NSs) were significantly larger in size, and twice more NPCs/NSCs were harvested from neonatal NSs, when compared to the GMF controls. The self-renewal capacity and multipotency of the NSs were maintained, as HMF-exposed NSs were positive for NSC markers (Nestin and Sox2), and could differentiate into neurons and astrocyte/glial cells and be passaged continuously. In addition, adult mice exposed to the HMF for one month were observed to have a greater number of proliferative cells in the subventricular zone. These findings indicate that continuous HMF-exposure increases the proliferation of NPCs/NSCs, in vitro and in vivo. HMF-disturbed NPCs/NSCs production probably affects brain development and function, which provides a novel clue for elucidating the cellular mechanisms of the bio-HMF response.Electronic supplementary materialThe online version of this article (doi:10.1007/s13238-016-0300-7) contains supplementary material, which is available to authorized users.

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“…In this regard, the geomagnetic field is not a real SMF (it is a quasi SMF) but it is considered to be essential to living organisms as a natural, pervasive, and ubiquitous weak magnetic field. It is reported that shielding of the geomagnetic field caused biological alterations, e.g., a decrease of the vital functions in bacteria [5], amnesia in fruit flies [6], early developmental abnormalities in newts [7], attenuation of opioid induced analgesia in mice [8], and a decrease of the noradrenergic activities in the brainstem of golden hamsters [9].…”

Section: Weak Intensity Fieldsmentioning

confidence: 99%

Effects of Static Magnetic Fields on Blood Pressure in Animals and Humans

Okano

2008

CHYR

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It is presumed that life on Earth has evolved in the presence of natural and ubiquitous magnetic fields. It is not surprising that biological systems can respond to a wide range of static magnetic fields (SMF). It is suggested that some physiological responses seem to be mediated through the nervous system. For weak intensity SMF, the effects of geomagnetic activity on the arterial baroreflex (reflex initiated by receptors in the aortic arch that alter peripheral vasomotion) in conscious animals were investigated by measuring blood pressure and microcirculation. Baroreflex sensitivity (BRS) was assessed as an indicator of cardiac autonomic regulation on the basis of the heart rate/mean arterial blood pressure relationship during a vasodilator (sodium nitroprusside) or a vasoconstrictor (phenylephrine) treatment. This study suggests that the geomagnetic field directly modifies microcirculatory responses related to BRS. These findings may have serious implications for individuals with ischemic diseases during periods of intense geomagnetic activity or geomagnetic storms. Concerning the moderate intensity SMF effects, pharmacological procedures and experimental animals have been used to assess the sympathetic responsiveness to SMF. We have reported that continuous exposure to moderate intensity SMF for several weeks can depress or suppress the action of sympathetic agonists (norepinephrine, phenylephrine, and dobutamine) and a sympathetic antagonist (reserpine) on hemodynamics and/or blood pressure by modulating sympathetic nerve activity or BRS in animals. In contrast, in humans there is little evidence to suggest that the SMF exposure of up to 8 tesla can alter blood pressure. Thus, this review describes the SMF effects (and non-effects) on the blood pressure in animals and humans.

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Exposure to hypomagnetic field space for multiple generations causes amnesia in Drosophila melanogaster

Cited by 54 publications

References 20 publications

Laboratory behavioural assay of insect magnetoreception:magnetosensitivity of Periplaneta americana

Laboratory behavioural assay of insect magnetoreception:magnetosensitivity of Periplaneta americana

Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells

Effects of Static Magnetic Fields on Blood Pressure in Animals and Humans

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