Exposure to house dust mite allergens and the clinical activity of asthma

Čustović, Adnan; Taggart, Simon; Francis, Helen; Chapman, Martin D.; Woodcock, Ashley

doi:10.1016/s0091-6749(96)70227-0

Cited by 233 publications

(149 citation statements)

References 38 publications

(15 reference statements)

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“…Our results demonstrate that allergenimpermeable covers in combination with weekly laundering of nonencased bedding materials can result in reductions in bed HDM allergens, in accordance with results of previous tests of these methods (5,9,15,(25)(26)(27)(28)(29)(30). The intervention that was implemented as part of this study resulted in bedding-dust HDM allergen concentrations < 10 µg/g, an exposure level threshold linked to asthma development (1) and acute asthma attacks (31).…”

Section: Discussionsupporting

confidence: 88%

“…A large body of evidence suggests that exposure to common indoor environmental allergens, including the house dust mite (HDM) allergens Dermatophagoides pteronyssinus allergen 1 (Der p 1) and Dermatophagoides farinae allergen 1 (Der f 1), is an important risk factor for allergic sensitization, asthma development, and asthma symptom exacerbation (1)(2)(3)(4)(5). Interventions to reduce HDM and food allergen exposure during the first 9 months of life have been reported to result in a decrease in the frequency of asthma, allergic rhinitis, and eczema at 12 months of age, suggesting that early allergen avoidance may indeed prevent the development of allergic diseases and asthma (6).…”

mentioning

confidence: 99%

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Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes.

Vojta

Randels

Stout

et al. 2001

Environ Health Perspect

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House dust mite allergen exposure is a postulated risk factor for allergic sensitization, asthma development, and asthma morbidity; however, practical and effective methods to mitigate these allergens from low-income, urban home environments remain elusive. The purpose of this study was to assess the feasibility and effectiveness of physical interventions to mitigate house dust mite allergens in this setting. Homes with high levels of house dust mite allergen (Der f 1 + Der p 1 > or = 10 microg/g dust by enzyme-linked immunosorbent assay) in the bed, bedroom carpet, and/or upholstered furniture were enrolled in the study. Carpets and upholstered furniture were subjected to a single treatment of either dry steam cleaning plus vacuuming (carpet only) or intensive vacuuming alone. Bed interventions consisted of complete encasement of the mattress, box spring, and pillows plus either weekly professional or in-home laundering of nonencased bedding. Dust samples were collected at baseline and again at 3 days (carpet and upholstery only) and 2, 4, and 8 weeks posttreatment. We compared pretreatment mean allergen concentrations and loads to posttreatment values and performed between-group analyses after adjusting for differences in the pretreatment means. Both dry steam cleaning plus vacuuming and vacuuming alone resulted in a significant reduction in carpet house dust mite allergen concentration and load (p < 0.05). Levels approached pretreatment values by 4 weeks posttreatment in the intensive vacuuming group, whereas steam cleaning plus vacuuming effected a decrease that persisted for up to 8 weeks. Significant decreases in bed house dust mite allergen concentration and load were obtained in response to encasement and either professional or in-home laundering (p < 0.001). Between-group analysis revealed significantly less postintervention house dust mite allergen load in professionally laundered compared to home-laundered beds (p < 0.05). Intensive vacuuming and dry steam cleaning both caused a significant reduction in allergen concentration and load in upholstered furniture samples (p < 0.005). Based on these data, we conclude that physical interventions offer practical, effective means of reducing house dust mite allergen levels in low-income, urban home environments.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes.

Vojta

Randels

Stout

et al. 2001

Environ Health Perspect

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“…Attempting to convert our results to likely Der p 1 levels can only yield approximate values. Custovic (10) The value of 2000 ng g -1 of Der p 1 in settled dust is often quoted as the threshold for the risk of sensitisation (11). Our data suggest that 25 % of the matched households would exceed this.…”

Section: Resultsmentioning

confidence: 64%

Levels of house dust mite allergen in cars / Razine alergena prašinskih grinja u automobilima

Mason

Smith

Anua

et al. 2015

Archives of Industrial Hygiene and Toxicology

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This small study investigated house dust mite (HDM) allergen levels in cars and their owners' homes in north-east Scotland. Dust samples from twelve households and cars were collected in a standardised manner. The dust samples were extracted and measured for the Dermatophagoides group 2 allergens (Der p 2 and Der f 2) and total soluble protein. Allergen levels at homes tended to be higher than in the cars, but not significantly. However, they significantly correlated with paired car dust samples expressed either per unit weight of dust or soluble protein (rho=0.657; p=0. 02 and 0.769; p=0.003, respectively). This points to house-to-car allergen transfer, with the car allergen levels largely reflecting levels in the owner's home. Car HDM allergen levels were lower than those reported in Brazil and the USA. Twenty-five percent of the houses and none of the cars had allergen levels in dust greater than 2000 ng g -1 . This value is often quoted as a threshold for the risk of sensitisation, although a number of studies report increased risk of sensitisation at lower levels. This small study does not allow for characterisation of the distribution of HDM allergen in vehicles in this geographic area, or of the likely levels in other warmer and more humid areas of the UK. Cars and other vehicles are an under-investigated micro-environment for exposure to allergenic material.

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“…Nas crianças eles são os seguintes: os alérgenos inaláveis (ácaros domésticos: D. pteronyssinus, D. farinae e a Blomia tropicalis; fungos; alérgenos eliminados de animais: gato, cão e pássaros e de baratas), as infecções das vias aéreas superiores, as mudanças climáticas, a exposição a poluentes ambientais (fumaça de tabaco e outros irritantes), o exercício e fatores emocionais 7,[30][31][32] . A identificação desses fatores envolvidos na gênese e/ou agravamento da asma é o primeiro passo para o estabelecimento de um plano de tratamento efetivo.…”

Section: Tratamento Da Asma Na Intercrise 1 -Considerações Geraisunclassified

Asthma in children: classification and treatment

Solé

Ic²,

Mc³

et al. 1998

J Pediatr (Rio J)

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ResumoObjetivos: Rever conceitos, gravidade e planos de tratamento a longo prazo da asma na criança.Método: Identificar os agentes desencadeantes e/ou agravantes dos quadros agudos de asma e classificá-la para permitir-se o estabelecimento de um plano de tratamento a longo prazo.Resultado: Classificada como leve, moderada e grave, a asma terá planos distintos de manejo, ficando a abordagem com agentes antiinflamatórios reservada às formas moderada e grave.Conclusões: No tratamento do paciente asmático, a identificação e o controle dos agentes etiológicos e dos possíveis agravantes é parte fundamental. A via inalatória é a mais adequada para a administração de fármacos a pacientes asmáticos. As principais drogas habitualmente utilizadas no tratamento da asma são revistas e o emprego precoce de glicocorticosteróides inalados tem sido recomendado pela maioria dos autores.J. pediatr. (Rio J.). 1998; 74 (Supl.1): S48-S58: asma, alérge-nos, criança, tratamento, terapia inalatória, imunoterapia. AbstractObjectives: To review concepts, classification based on severity, and long term treatment for children with asthma.Methods: To identify precipitating factors of acute asthma attacks and classify the disease in order to establish long term treatment.Results: Different plans of management according to its classification: mild, moderate and severe asthma. Antiinflammatory therapy is reserved to moderate and severe asthma.Conclusions: The identification and control of the etiologic and precipitating factors are important tasks in the management of asthma. The inhalatory route is the most appropriate to treat patients suffering from asthma. The usual drugs indicated in asthma treatment are reviewed. Precocious treatment with inhaled glucocorticosteroids is recommended by several authors. J. pediatr. (Rio J. IntroduçãoA asma é definida pelo II Consenso Brasileiro no Manejo da Asma como uma doença crônica das vias aéreas caraterizada por a) obstrução ao fluxo aéreo reversível (embora não completamente em alguns pacientes) espontaneamente ou com tratamento; b) inflamação em que muitas células têm um papel importante, em particular mastócitos e eosinófilos; c) aumento da reatividade das vias aéreas a uma variedade de estímulos (hiper-responsividade brônquica = HRB); d) episódios recidivantes de sibilância, dispnéia, aperto no peito e tosse, particularmente à noite e pela manhã ao acordar 1 .A análise de fragmentos de mucosa brônquica obtidos por endoscopia, mesmo de indivíduos com asma leve e de início recente, ou por autópsia de indivíduos asmáticos falecidos durante episódio agudo, revela alterações características que variam de intensidade segundo a gravidade da asma. Estas alterações incluem: a) infiltração da mucosa e submucosa com células inflamatórias (especialmente eosinófilos e linfócitos T), b) descamação irregular do epitélio, c) espessamento da musculatura lisa da via aérea, d) fibrose subepitelial, e) hiperplasia de glândulas mucosas e de células caliciformes e f) tampões mucosos disseminados na asma fatal 2,3 .O p...

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Exposure to house dust mite allergens and the clinical activity of asthma

Cited by 233 publications

References 38 publications

Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes.

Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes.

Levels of house dust mite allergen in cars / Razine alergena prašinskih grinja u automobilima

Asthma in children: classification and treatment

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