Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years

Smink, A.; Ribas-Fitó, Núria; García, Rafael Clua; Torrent, Maties; Mendez, Michelle A.; Grimalt, Joan O.; Sunyer, Jordi

doi:10.1111/j.1651-2227.2008.00937.x

Cited by 143 publications

(103 citation statements)

References 34 publications

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“…Thus, it is possible that other chemicals than PCB and DDE could have contributed to the observed effects. For example, prenatal exposure to hexachlorobenzene, which is a persistent organic pollutant highly correlated to PCB and DDE, has been reported to cause overweight in children (39). However, the serum concentration of hexachlorobenzene in this study was close to the limit of detection and much lower than that of PCB and DDE, and therefore, we believe it was unlikely that hexachlorobenzene was responsible for the observed effects.…”

Section: Tablecontrasting

confidence: 51%

Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands

Tang-Péronard¹,

Heitmann²,

Andersen³

et al. 2014

The American Journal of Clinical Nutrition

108

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Background: Chemicals with endocrine-disrupting abilities may act as obesogens and interfere with the body's natural weight-control mechanisms, especially if exposure occurs during prenatal life. Objective: We examined the association between prenatal exposure to polychlorinated biphenyls (PCBs) and p,p#-dichlorodiphenyldichloroethylene (DDE) and subsequent obesity at 5 and 7 y of age. Design: From 1997 to 2000, 656 pregnant Faroese women were recruited. PCB and DDE were measured in maternal serum and breast milk, and children's weight, height, and waist circumference (WC) were measured at clinical examinations at 5 and 7 y of age. The change in body mass index (BMI) from 5 to 7 y of age was calculated. Analyses were performed by using multiple linear regression models for girls and boys separately, taking into account maternal prepregnancy BMI. Results: For 7-y-old girls who had overweight mothers, PCB was associated with increased BMI (b = 2.07, P = 0.007), and PCB and DDE were associated with an increased change in BMI from 5 to 7 y of age (PCB: b = 1.23, P = 0.003; DDE: b = 1.11, P = 0.008). No association was observed with BMI in girls with normal-weight mothers. PCB was associated with increased WC in girls with overweight mothers (b = 2.48, P = 0.001) and normal-weight mothers (b = 1.25, P = 0.04); DDE was associated with increased WC only in girls with overweight mothers (b = 2.21, P = 0.002). No associations were observed between PCB or DDE and BMI in 5-y-old girls. For boys, no associations were observed. Conclusions: Results suggest that prenatal exposure to PCB and DDE may play a role for subsequent obesity development. Girls whose mothers have a high prepregnancy BMI seem most affected.Am J Clin Nutr 2014;99:5-13.

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Section: Tablecontrasting

confidence: 51%

Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands

Tang-Péronard¹,

Heitmann²,

Andersen³

et al. 2014

The American Journal of Clinical Nutrition

108

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“…Neurotoxicity of these compounds is connected with Dopamine-based reward circuitry as well as the endocrine system, and lead to an increase of food intake and -in consequence -obesity. The problem is even more serious because some authors [95,[137][138] stated that exposure to pesticides and other environmental contaminants during the early stages of life could increase vulnerability to such substances in later life periods. According to WHO [139], as evidence grows on the fetal determinants of adult disease, the importance of promoting a healthier environment for pregnant women are recognized as priorities.…”

Section: Discussionmentioning

confidence: 99%

Are Environmental Contaminants Responsible for ‘Globesity’?

Filipiak‐Florkiewicz¹,

Topolska²,

Florkiewicz³

et al. 2017

Pol. J. Environ. Stud.

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“…The impact of prenatal exposure increasing the risk of obesity has been demonstrated in humans for maternal tobacco smoke [29]; dichlorodiphenyldichloroethylene (DDE), the metabolite of dichlorodiphenyltrichloroethane (DDT) [30,31]; hexachlorobenzene [32]; and polychlorinated biphenyls [33,34]. There is some indication that different polychlorinated biphenyl congeners may have different associations, and that sex and height may be confounders [35].…”

Section: Obesity and Type II Diabetesmentioning

confidence: 99%

Early-life risk factors for chronic nonrespiratory diseases

et al. 2014

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We have witnessed a change in disease patterns contributing to the global burden of disease, with a shift from early childhood deaths due to the classic infectious communicable diseases to years lived with disability from chronic noncommunicable diseases. In both developing and developed countries, the years lived with disability attributable to chronic disease have increased: cardiovascular diseases by 17.7%; chronic respiratory disease by 8.5%; neurological conditions by 12.2%; diabetes by 30.0%; and mental and behavioural disorders by 5.0% over the past 20 years. Recognition of the contribution made by adverse environmental exposures in early life to noncommunicable diseases in later life is increasing. These earlylife exposures appear to contribute to both chronic respiratory and chronic nonrespiratory diseases. In this State of the Art article, we aim to examine early-life environmental exposures that have an epidemiological association with chronic nonrespiratory diseases, such as obesity and type II diabetes, cardiovascular disease, and neurocognitive and behavioural problems. We will highlight the potential overlap in environmental risks with respiratory diseases, and point out knowledge gaps and research opportunities. @ERSpublications Respiratory diseases are linked to obesity/diabetes/metabolic syndrome, CVD and neurocognitive/behavioural disorders

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Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years

Abstract: Prenatal exposure to HCB is associated with an increase in BMI and weight at age 6.5 years. Further studies with larger samples and longer follow-up are needed to confirm these results.

Cited by 143 publications

References 34 publications

Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands

Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands

Are Environmental Contaminants Responsible for ‘Globesity’?

Early-life risk factors for chronic nonrespiratory diseases

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