Exposure to heavy metal-contaminated sediments disrupts gene expression, lipid profile, and life history traits in the midge Chironomus riparius

Arambourou, Hélène; Llorente, Lola; Moreno-Ocio, Iñigo; Herrero, Óscar; Barata, Carlos; Fuertes, Inmaculada; Delorme, Nicolas; Méndez-Fernández, Leire; Planelló, Rosario

doi:10.1016/j.watres.2019.115165

Cited by 40 publications

(15 citation statements)

References 74 publications

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“…47 The role of TAG in protection against ROS damage was proved in Cd 2+ -induced toxicity. 48 In the present study, the level of TAG in the Cd 2+ or AGSP−Cd 2+ group was more than 3 times that in the control group. Following the elevation of TAG, the direct precursor for TAG synthesis, DG, increased significantly after Cd 2+ or AGSP−Cd 2+ treatment as well.…”

Section: ■ Discussionsupporting

confidence: 42%

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Enhanced Cytotoxicity of Cadmium by a Sulfated Polysaccharide from Abalone

Wang

Song

et al. 2020

J. Agric. Food Chem.

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Consumption of seafood is a common route of cadmium ion (Cd2+) exposure to consumers. The seafood matrices may alter the toxicity profile of Cd2+ due to the interaction between Cd2+ and biomacromolecules in seafood. In this study, enhanced cytotoxicity of Cd2+ was found in the presence of an abalone gonad sulfated polysaccharide (AGSP) and the mechanism was investigated at a metabolic level. The formation of the AGSP–Cd2+ complex was demonstrated by isothermal titration calorimetry. The level of reactive oxygen species (ROS) increased and mitochondrial membrane potential reduced upon exposure to the AGSP–Cd2+ complex as compared with those of Cd2+ exposure. The decreased cell viability after incubation with the AGSP–Cd2+ complex also suggested enhanced Cd2+ toxicity induced by AGSP. The metabolomics and lipidomics analysis revealed that, compared with the Cd2+ group, the AGSP–Cd2+ downregulated the phospholipid metabolism and resulted in more serious damage in the cellular membrane. The lipid metabolism disorder, in turn, amplified the generation of ROS, leading to a decrease in cell viability. These results provided new evidence of the enhanced Cd2+ toxicity upon interaction with seafood polysaccharides, and much attention should be paid to the effect of food ingredients on heavy metal ion toxicity.

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Section: ■ Discussionsupporting

confidence: 42%

“…Additionally, ROS could trigger the lipogenesis pathway involved in TAG synthesis in glia . The role of TAG in protection against ROS damage was proved in Cd 2+ -induced toxicity . In the present study, the level of TAG in the Cd 2+ or AGSP–Cd 2+ group was more than 3 times that in the control group.…”

Section: Discussionmentioning

confidence: 41%

Enhanced Cytotoxicity of Cadmium by a Sulfated Polysaccharide from Abalone

Wang

Song

et al. 2020

J. Agric. Food Chem.

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“…All stock solutions were prepared according to the sediment dry weight (dw) and resulted in five nominal contents of 0, 0.7, 2, 6, and 18 mg/kg for Cd and 0, 25, 50, 100, and 200 mg/kg for Cu. These environmentally relevant metal contents were chosen based on field data (measured contents range from 0.3 to 33 mg Cd/kg dw and 1.0 to 3100 mg Cu/kg dw , ) and published effect thresholds for C. riparius (e.g., Marinković et al).…”

Section: Methodsmentioning

confidence: 99%

Metal Exposure and Sex Shape the Fatty Acid Profile of Midges and Reduce the Aquatic Subsidy to Terrestrial Food Webs

Pietz

Kainz

Schroeder

et al. 2023

Environ. Sci. Technol.

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Aquatic micropollutants can be transported to terrestrial systems and their consumers by emergent aquatic insects. However, micropollutants, such as metals, may also affect the flux of physiologically important polyunsaturated fatty acids (PUFAs). As certain PUFAs have been linked to physiological fitness and breeding success of terrestrial consumers, reduced fluxes from aquatic systems could affect terrestrial populations and food webs. We chronically exposed larvae of the aquatic insect Chironomus riparius to a range of environmentally relevant sediment contents of cadmium (Cd) or copper (Cu) in a 28-day microcosm study. Since elevated water temperatures can enhance metals' toxic effects, we used two temperature regimes, control and periodically elevated temperatures (heat waves) reflecting an aspect of climate change. Cd and Cu significantly reduced adult emergence by up to 95% and 45%, respectively, while elevated temperatures had negligible effects. Both metal contents were strongly reduced (∼90%) during metamorphosis. Furthermore, the chironomid FA profile was significantly altered during metamorphosis with the factors sex and metal exposure being relevant predictors. Consequently, fluxes of physiologically important PUFAs by emergent adults were reduced by up to ∼80%. Our results suggest that considering fluxes of physiologically important compounds, such as PUFAs, by emergent aquatic insects is important to understand the implications of aquatic micropollutants on aquatic-terrestrial meta-ecosystems.

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“…High ecological risk induced by these five heavy metals demonstrates that human activities have greatly affected the river environment. At the same time, rivers can release these pollutants again, causing ecological risks [40,41].…”

Section: Assessment Of Heavy Metals Pollution In Sedimentmentioning

confidence: 99%

Contamination and Ecological Risk Assessment of Heavy Metals in Surface Sediments of Huangshui River, Northwest China

Fang

Wei²,

et al. 2022

Journal of Chemistry

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In the Xining area of Huangshui River, China, the concentrations of globally alarming toxic heavy metals such as chromium (Cr), arsenic (As), lead (Pb), cadmium (Cd), and zinc (Zn) in the surface sediments were measured to determine the ecological risks to the riverine ecosystem. Overall, the concentrations of heavy metals in the surface sediments were relatively high. The results indicated that the concentrations of Pb/Zn/Cr were lower than 120/250/200 mg·kg−1 which was the risk screening value of each heavy metal for soil contamination of agricultural land (GB15618-2018). The concentrations of As/Cd were higher than 120/3.0 mg·kg−1 which was the risk intervention value of As/Cd for soil contamination of agricultural land (GB15618-2018). Their values were arranged in the following decreasing order: As (151.23–818.55 mg·kg−1) > Cr (44.18–201.70 mg·kg−1) > Pb (29.10–121.95 mg·kg−1) > Zn (1.45–86.18 mg·kg−1) > Cd (4.36–6.21 mg·kg−1). The concentrations of As, Cr Pb, and Cd greatly exceeded the background contents of elements in Qinghai soils. While Zn was lower than background. The contamination factor (CF), the geoaccumulation index (Igeo), and the potential ecological risk index (RI) of As, Cr, Cd, and Pb followed the descending order of Cd > As > Pb > Cr > Zn. The order of the enrichment factor (EF) was as follows: As > Cd > Pb > Cr > Zn. The contamination level of heavy metals implied that the condition is frightening and probably severely affecting the aquatic ecology. Cd and As were the main contributing elements to the ecological risk of the sediments in the Xining area of the Huangshui River, which should be mainly studied and prevented.

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Exposure to heavy metal-contaminated sediments disrupts gene expression, lipid profile, and life history traits in the midge Chironomus riparius

Cited by 40 publications

References 74 publications

Enhanced Cytotoxicity of Cadmium by a Sulfated Polysaccharide from Abalone

Enhanced Cytotoxicity of Cadmium by a Sulfated Polysaccharide from Abalone

Metal Exposure and Sex Shape the Fatty Acid Profile of Midges and Reduce the Aquatic Subsidy to Terrestrial Food Webs

Contamination and Ecological Risk Assessment of Heavy Metals in Surface Sediments of Huangshui River, Northwest China

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