Exposure to hazardous air pollutants and the risk of amyotrophic lateral sclerosis

Malek, Angela M.; Barchowsky, Aaron; Bowser, Robert; Heiman‐Patterson, Terry; Lacomis, David; Rana, Sandeep; Youk, Ada O.; Talbott, Evelyn O.

doi:10.1016/j.envpol.2014.12.010

Cited by 68 publications

(47 citation statements)

References 43 publications

(49 reference statements)

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“…Although there are only a few studies that relate exposure to air pollutants as a result of traffic and the occurrence of ALS [32, 53, 54], our results are similar. Seelen et al [54] in particular, find that, as in our case, once adjusted for possible confounders, the risk of ALS is significantly higher for subjects with high levels of exposure to NO 2 .…”

Section: Discussionsupporting

confidence: 81%

“…Using a case-control study from 2008 to 2011 in 6 counties surrounding Pittsburgh, the United States, Malek et al [53] investigated the association between being exposed to air pollution and the occurrence of ALS and found that aromatic solvents significantly elevated the risk of ALS (OR 5.03, 95% CI 1.29–19.53). In fact, the possible influence exposure to solvents has, although interacting with heritability and male sex, had already been found by Gunnarsson et al [30] through a population-based case-control study in central and southern Sweden in 1990.…”

Section: Introductionmentioning

confidence: 99%

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Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

et al. 2018

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Background: It is believed that an interaction between genetic and non-genetic factors may be involved in the development of amyotrophic lateral sclerosis (ALS). With the exception of exposure to agricultural chemicals like pesticides, evidence of an association between environmental risk factors and ALS is inconsistent. Our objective here was to investigate the association between long-term exposure to environmental factors and the occurrence of ALS in Catalonia, Spain, and to provide evidence that spatial clusters of ALS related to these environmental factors exist. Methods: We carried out a nested case-control study constructed from a retrospective population-based cohort, covering the entire region. Environmental variables were the explanatory variables of interest. We controlled for both observed and unobserved confounders. Results: We have found some spatial clusters of ALS. The results from the multivariate model suggest that these clusters could be related to some of the environmental variables, in particular agricultural chemicals. In addition, in high-risk clusters, besides corresponding to agricultural areas, key road infrastructures with a high density of traffic are also located. Conclusion: Our results indicate that some environmental factors, in particular those associated with exposure to pesticides and air pollutants as a result of urban traffic, could be associated with the occurrence of ALS.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

et al. 2018

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“…However, another study with the same approach conducted by Malek et al 17 found no association between pesticides and the development of amyotrophic lateral sclerosis (ALS).…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, two epidemiological case-control studies that sought to associate exposure of air contaminated with pesticides were not published in public health journals, commonly observed in investigations with this objective and approach 17,19 .…”

Section: Resultsmentioning

confidence: 99%

Presença de agrotóxicos na atmosfera e risco à saúde humana: uma discussão para a Vigilância em Saúde Ambiental

Souza

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Maciel

et al. 2017

Ciênc. saúde coletiva

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“…Some methodological questions arise in the article by Malek et al (2014), which looked at possibility that air pollutants increase the risk of amyotrophic lateral sclerosis (ALS).…”

Section: Editormentioning

confidence: 99%

Letter to the Editor on “Exposure to hazardous air pollutants and the risk of amyotrophic lateral sclerosis”

Kullmann¹

2015

Environmental Pollution

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Exposure to hazardous air pollutants and the risk of amyotrophic lateral sclerosis

Cited by 68 publications

References 43 publications

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

Presença de agrotóxicos na atmosfera e risco à saúde humana: uma discussão para a Vigilância em Saúde Ambiental

Letter to the Editor on “Exposure to hazardous air pollutants and the risk of amyotrophic lateral sclerosis”

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