Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood

Yusof, Nurfadhilah; Hamid, Noor Aman; Feei, Zheng; Lawenko, Rona Marie; Mohammad, Wan Mohd Zahiruddin Wan; Collins, Deirdre A.; Liong, Min‐Tze; Odamaki, Toshitaka; Xiao, Jin‐zhong; Lee, Yeong Yeh

doi:10.1186/s13099-017-0224-7

Cited by 33 publications

(33 citation statements)

References 28 publications

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“…The gut microbiota in the human colon is also affected by the diet and induces metabolic diseases, like type II diabetes. In other words, dietary changes can improve physiological metabolism in humans by modifying microbial metabolic processes [ 76 , 77 ]. In a comparison of the gut microbiota, 53% of children in the African countryside, but not in Europe, had Prevotella.…”

Section: Discussionmentioning

confidence: 99%

Effects of Tempeh Fermentation with Lactobacillus plantarum and Rhizopus oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Huang

Chu

et al. 2018

Nutrients

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The increased consumption of high fat-containing foods has been linked to the prevalence of obesity and abnormal metabolic syndromes. Rhizopus oligosporus, a fungus in the family Mucoraceae, is widely used as a starter for homemade tempeh. Although R. oligosporus can prevent the growth of other microorganisms, it grows well with lactic acid bacteria (LAB). Lactobacillus plantarum can produce β-glucosidase, which catalyzes the hydrolysis of glucoside isoflavones into aglycones (with greater bioavailability). Therefore, the development of a soybean-based functional food by the co-inoculation of R. oligosporus and L. plantarum is a promising approach to increase the bioactivity of tempeh. In this study, the ameliorative effect of L. plantarum in soy tempeh on abnormal carbohydrate metabolism in high-fat diet (HFD)-induced hyperglycemic rats was evaluated. The co-incubation of L. plantarum with R. oligosporus during soy tempeh fermentation reduced the homeostatic model assessment of insulin resistance, HbA1c, serum glucose, total cholesterol, triglyceride, free fatty acid, insulin, and low-density lipoprotein contents, and significantly increased the high-density lipoprotein content in HFD rats. It also increased the LAB counts, as well as the bile acid, cholesterol, triglyceride, and short-chain fatty acid contents in the feces of HFD rats. Our results suggested that the modulation of serum glucose and lipid levels by LAB occurs via alterations in the internal microbiota, leading to the inhibition of cholesterol synthesis and promotion of lipolysis. Tempeh, which was produced with both L. plantarum and R. oligosporus, might be a beneficial dietary supplement for individuals with abnormal carbohydrate metabolism.

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Section: Discussionmentioning

confidence: 99%

Effects of Tempeh Fermentation with Lactobacillus plantarum and Rhizopus oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Huang

Chu

et al. 2018

Nutrients

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“…We then applied a machine learning method (Random Forest) to our genus level data set, identifying Catenibacterium and Megamonas as bacterial discriminants of aggressive behavior. Respectively belonging to the families Erysipelotrichaceae and Veillonellaceae, Catenibacterium and Megamonas have been recently correlated with primary bile acid metabolism and abdominal pain in humans [42–44], suggesting a possible connection between a dysbiotic GM profile and behavioral disorders. We found no alteration within the GM of dogs with phobic behavioral disorder except for an increase in Lactobacillus , bacterial genera with well-known probiotic properties.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders

Mondo

Barone

Soverini

et al. 2019

Preprint

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27Accompanying human beings since the Paleolithic period, dogs has been recently regarded as a 28 reliable model for the study of the gut microbiome connections with health and disease. In order to 29 provide some glimpses on the connections between the gut microbiome layout and host behavior, 30 we profiled the phylogenetic composition and structure of the canine gut microbiome of dogs with 31 aggressive (n = 17), phobic (n = 15) and normal behavior (n = 17). According to our findings, 32 aggressive behavioral disorder was found to be characterized by a peculiar gut microbiome 33 structure, with high biodiversity and enrichment in generally subdominant bacterial genera. On the 34 other hand, phobic dogs were enriched in Lactobacillus, a bacterial genus with known probiotic and 35 psychobiotic properties. Although further studies are needed to validate our findings, our work 36 supports the intriguing opportunity that different behavioral phenotypes in dogs may be associated 37 with peculiar gut microbiome layouts, suggesting possible connections between the gut microbiome 38 and the central nervous system and indicating the possible adoption of probiotic interventions aimed 39 at restoring a balanced host-symbiont interplay for mitigating behavioral disorders. 40 41 42 Keywords: microbiome, behavioral disorders, aggressive dogs, phobic dogs, hormones, HPA-axis 43 44 45 46 47 48 49 50 51 52 Descending from the gray wolf (Canis lupus), dogs were domesticated during the Paleolithic 53 period, accompanying humans across the transition from hunting-gathering to rural agriculture of 54 the Neolithic, to post-industrialized Western lifestyle [1-3]. The frequent sharing of food resources 55with human beings has been a selective force able to drive changes in the digestive and metabolic 56 system of dogs, enabling them to efficiently adapt to a more starch-enriched diet compared to their 57 wild ancestor, and ultimately influence canine behavior [4,5]. The canine gastrointestinal tract 58 harbors a complex and highly biodiverse microbial ecosystem, whose predominant taxa resemble 59 those typically found in the gut of other omnivorous mammals. However, in comparison to both 60 mice and pigs, the canine gut microbiome (GM) result the most similar to humans [6,7]. Thus, in 61 dogs, the GM-host mutualistic exchange well approximate what has been observed in humans [8-62 11]. Indeed, the peculiar patterns of dysbiosis observed in dogs with IBD are generally comparable 63 to variations typically found in humans, suggesting that bacterial responses to inflammatory 64 conditions are conserved among the two [12,13]. As observed in humans, the eubiotic and stable 65 configuration of the canine GM is therefore of fundamental importance for the maintenance of a 66 homeostatic gut environment and of the overall host health. 67Several recent studies have shown the ability of the mammalian GM to communicate with the host 68 central nervous system (CNS) through several parallel channels, involving the vagus nerve, 69 neuroimmune and ...

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“…Dysbiosis in the gut microbiota has been shown to cause IBS, for example, exposure of environmental microbiota had led to the development of IBS after a major flood disaster . On the other hand, diet is an important determinant of gut microbiota abundance and diversity, especially in early life, where it may impact health and diseases in later life, including IBS …”

Section: Methodsmentioning

confidence: 99%

Low fermentable oligosaccharides, disaccharides, monosaccharides, and polypols diet and irritable bowel syndrome in Asia

et al. 2018

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Functional bowel disorders, including irritable bowel syndrome (IBS), are a chronic condition that can significantly reduce patients’ quality of life. Therefore, this paper will review the roles of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polypols (FODMAP) diet in treating IBS, particularly in an Asian setting. About 20% of the general population is diagnosed with IBS. However, there are limited effective medical therapies available for treating IBS. Therefore, IBS presents a major challenge to the health‐care providers. Recently, there is an increasing interest in the use of a diet low in FODMAP for the treatment of IBS. A low FODMAP diet can decrease the delivery of readily fermentable substrates to the small intestine and colon, thereby improving functional gastrointestinal symptoms.

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Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood

Cited by 33 publications

References 28 publications

Effects of Tempeh Fermentation with Lactobacillus plantarum and Rhizopus oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Effects of Tempeh Fermentation with Lactobacillus plantarum and Rhizopus oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders

Low fermentable oligosaccharides, disaccharides, monosaccharides, and polypols diet and irritable bowel syndrome in Asia

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