Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology

Berardino, Bruno Gabriel; Chertoff, Mariela; Gianatiempo, Octavio; Alberca, Carolina D.; Priegue, Rocío; Fiszbein, Ana; Long, Patrick; Corfas, Gabriel; Cánepa, Eduardo T.

doi:10.1016/j.neuroscience.2019.03.027

Cited by 13 publications

(8 citation statements)

References 92 publications

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“…Besides an upregulation of miR-132 in response to distress, some studies also observed a significant downregulation of miR-132 in response to social and physical enrichment 50 , 51 . This result implies that the upregulation of miR-132 might function as biomarker for distress and that its downregulation indicates well-being of animals.…”

Section: Discussionmentioning

confidence: 99%

“…The expression of miR-132 in response to stress was quantified primarily in tissue, such as hippocampus 43,44,46,47,50,52,53 , spinal cord 54 or dorsal root ganglia 55 . In contrast to the mentioned literature, the present study proved that the stress-specific deregulation of miR-132 is not just locally restricted to neuronal tissue, but can also be quantified systemically in the blood.…”

Section: Discussionmentioning

confidence: 99%

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MicroRNAs as systemic biomarkers to assess distress in animal models for gastrointestinal diseases

Kumstel

Janssen-Peters

Abdelrahman

et al. 2020

Sci Rep

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Severity assessment of animal experiments is mainly conducted by using subjective parameters. A widely applicable biomarker to assess animal distress could contribute to an objective severity assessment in different animal models. Here, the distress of three murine animal models for gastrointestinal diseases was assessed by multiple behavioral and physiological parameters. To identify possible new biomarkers for distress 750 highly conserved microRNAs were measured in the blood plasma of mice before and after the induction of pancreatitis. Deregulated miRNA candidates were identified and further quantified in additional animal models for pancreatic cancer and cholestasis. MiR-375 and miR-203 were upregulated during pancreatitis and down regulated during cholestasis, whereas miR-132 was upregulated in all models. Correlation between miR-132 and plasma corticosterone concentrations resulted in the highest correlation coefficient, when compared to the analysis of miR-375, miR-203 and miR-30b. These results indicate that miR-132 might function as a general biomarker for distress, whereas the other miRNAs were altered in a disease specific manner. In conclusion, plasma miRNA profiling may help to better characterize the level of distress in mouse models for gastrointestinal diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

MicroRNAs as systemic biomarkers to assess distress in animal models for gastrointestinal diseases

Kumstel

Janssen-Peters

Abdelrahman

et al. 2020

Sci Rep

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“…Finally, we previously showed a similar rescue of anxiety-like behaviour in perinatal malnourished male mice that was linked to the expression of three miRNAs (miR-187-3p, miR-369-3p, and miR-132-3p) [24]. None of these miRNAs are closer than 100,000 base pairs from any of the DhMRs, indicating that it is unlikely that DNA hydroxymethylation is directly regulating their expression following perinatal malnutrition.…”

Section: Enriched Environment Restoration Of Aberrant 5hmc Levels Is ...mentioning

confidence: 78%

“…Here, we show that perinatal malnutrition-induced anxiety-like behaviours in adult female mice and that post-weaning exposure to a social and sensory stimulation (enriched environment) rescued this behaviour. Several studies in both humans and rodents have demonstrated that maternal malnutrition affects neurocognitive and neuropsychological development [39] and increases the risk to develop behavioural disorders [24,33,40]. In contrast, the combination of enriched environment improves both behavioural and molecular components: reduces anxiety-like responses [41], enhances dendritic branching and spine density in the hippocampus [42], increases the cortical and whole-brain weight [43], and stimulates hippocampal neurogenesis [44].…”

Section: Discussionmentioning

confidence: 99%

“…The molecular impact of a social and sensory stimulation (enriched environment) on the development of the brain has been deeply studied in rodents: enriched environment improves spatial learning [22] and memory [23], and ameliorates anxiety-like behaviour [24]. An enriched environment also enhances neuronal plasticity and attenuates cognitive deficits caused by brain lesions, such as cortical or hippocampal injuries [25], degeneration of cerebellar cortex [26], prenatal alcohol exposure [27], and anoxia [28].…”

Section: Introductionmentioning

confidence: 99%

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Perinatal protein malnutrition results in genome-wide disruptions of 5-hydroxymethylcytosine at regions that can be restored to control levels by an enriched environment

et al. 2020

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Maternal malnutrition remains one of the major adversities affecting brain development and longterm mental health outcomes, increasing the risk to develop anxiety and depressive disorders. We have previously shown that malnutrition-induced anxiety-like behaviours can be rescued by a social and sensory stimulation (enriched environment) in male mice. Here, we expand these findings to adult female mice and profiled genome-wide ventral hippocampal 5hmC levels related to malnutrition-induced anxiety-like behaviours and their rescue by an enriched environment. This approach revealed 508 differentially hydroxymethylated genes associated with protein malnutrition and that several genes (N = 34) exhibited a restored 5hmC abundance to control levels following exposure to an enriched environment, including genes involved in neuronal functions like dendrite outgrowth, axon guidance, and maintenance of neuronal circuits (e.g. Fltr3, Itsn1, Lman1, Lsamp, Nav, and Ror1) and epigenetic mechanisms (e.g. Hdac9 and Dicer1). Sequence motif predictions indicated that 5hmC may be modulating the binding of transcription factors for several of these transcripts, suggesting a regulatory role for 5hmC in response to perinatal malnutrition and exposure to an enriched environment. Together, these findings establish a role for 5hmC in early-life malnutrition and reveal genes linked to malnutrition-induced anxious behaviours that are mitigated by an enriched environment.

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Environmental Factors and Epigenetics

Weber‐Stadlbauer

Richetto

2022

Encyclopedia of Behavioral Neuroscience, 2nd Edition

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Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology

Cited by 13 publications

References 92 publications

MicroRNAs as systemic biomarkers to assess distress in animal models for gastrointestinal diseases

MicroRNAs as systemic biomarkers to assess distress in animal models for gastrointestinal diseases

Perinatal protein malnutrition results in genome-wide disruptions of 5-hydroxymethylcytosine at regions that can be restored to control levels by an enriched environment

Environmental Factors and Epigenetics

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