Exposure to echimidine impairs the heart development and function of zebrafish larvae

Lin, Tingting; Zhou, Li; Chen, Zhibin; Wang, Luanjin; Yang, Jian; Wang, Sheng; Chen, Xintan; Zuo, Zhenghong; He, Chengyong; Guo, Lanping

doi:10.1016/j.ecoenv.2023.115574

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…In our study, the transcript level of cdh2 showed an increase in the cyprodinil-treated group (2.15-fold), but decreased to 0.89-fold in the cyprodinil plus ECG group. These results suggest that cyprodinil may lead to a decrease in the in ux of calcium ions from extracellular mediators into the cytoplasmic matrix, while ECG treatment can mitigate this effect (Lin et al, 2023). The restoration of gene expression levels in the cyprodinil plus ECG group suggests that ECG treatment can alleviate the adverse effects of cyprodinil on calcium channels-related genes, potentially restoring calcium homeostasis and maintaining normal cardiac function.…”

Section: Ecg Alleviated the Low Expression Of Cardiac Calcium Channel...mentioning

confidence: 79%

(-)-Epicatechin gallate ameliorates cyprodinil-induced cardiac developmental defects through inhibiting aryl hydrocarbon receptor in zebrafish

Huang,

Su,

et al. 2023

Preprint

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Cyprodinil is a widely used fungicide with broad-spectrum activity, but it has been associated with cardiac abnormalities. (-)-Epicatechin gallate (ECG), a natural polyphenolic compound, has been shown to possess protective properties in cardiac development. In this study, we investigated whether ECG could mitigate cyprodinil-induced heart defects using zebrafish embryos as a model. Zebrafish embryos were exposed to cyprodinil (500 µg/L) with or without ECG (1 µM). Our results demonstrated that ECG significantly improved the survival rate, embryo movement, and hatching delay induced by cyprodinil. Furthermore, ECG effectively ameliorated cyprodinil-induced cardiac developmental toxicity, including pericardial anomaly and impairment of cardiac function. Mechanistically, ECG attenuated the cyprodinil-induced alterations in mRNA expression related to cardiac development, such as amhc, vmhc, tbx5, and gata4, as well as calcium ion channels, such as ncx1h, atp2a2a, and cdh2. Additionally, ECG was found to inhibit the activity of the aryl hydrocarbon receptor (AhR) signaling pathways induced by cyprodinil. In conclusion, our findings provide evidence for the protective effects of ECG against cyprodinil-induced cardiac developmental toxicity, mediated through the inhibition of AhR activity. These findings contribute to a better understanding of the regulatory mechanisms and safe utilization of pesticide, such as cyprodinil.

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Section: Ecg Alleviated the Low Expression Of Cardiac Calcium Channel...mentioning

confidence: 79%

(-)-Epicatechin gallate ameliorates cyprodinil-induced cardiac developmental defects through inhibiting aryl hydrocarbon receptor in zebrafish

Huang,

Su,

et al. 2023

Preprint

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(−)‐Epicatechin gallate ameliorates cyprodinil‐induced cardiac developmental defects through inhibiting aryl hydrocarbon receptor in zebrafish

Huang,

Su,

et al. 2024

Birth Defects Research

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BackgroundCyprodinil is a widely used fungicide with broad‐spectrum activity, but it has been associated with cardiac abnormalities. (−)‐Epicatechin gallate (ECG), a natural polyphenolic compound, has been shown to possess protective properties in cardiac development.MethodsIn this study, we investigated whether ECG could mitigate cyprodinil‐induced heart defects using zebrafish embryos as a model. Zebrafish embryos were exposed to cyprodinil with or without ECG.ResultsOur results demonstrated that ECG significantly improved the survival rate, embryo movement, and hatching delay induced by cyprodinil. Furthermore, ECG effectively ameliorated cyprodinil‐induced cardiac developmental toxicity, including pericardial anomaly and impairment of cardiac function. Mechanistically, ECG attenuated the cyprodinil‐induced alterations in mRNA expression related to cardiac development, such as amhc, vmhc, tbx5, and gata4, as well as calcium ion channels, such as ncx1h, atp2a2a, and cdh2. Additionally, ECG was found to inhibit the activity of the aryl hydrocarbon receptor (AhR) signaling pathways induced by cyprodinil.ConclusionsIn conclusion, our findings provide evidence for the protective effects of ECG against cyprodinil‐induced cardiac developmental toxicity, mediated through the inhibition of AhR activity. These findings contribute to a better understanding of the regulatory mechanisms and safe utilization of pesticide, such as cyprodinil.

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Induction of oxidative stress and cardiac developmental toxicity in zebrafish embryos by arsenate at environmentally relevant concentrations

Wang,

Ye,

Liu

et al. 2024

Ecotoxicology and Environmental Safety

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Exposure to echimidine impairs the heart development and function of zebrafish larvae

Cited by 5 publications

References 37 publications

(-)-Epicatechin gallate ameliorates cyprodinil-induced cardiac developmental defects through inhibiting aryl hydrocarbon receptor in zebrafish

(-)-Epicatechin gallate ameliorates cyprodinil-induced cardiac developmental defects through inhibiting aryl hydrocarbon receptor in zebrafish

(−)‐Epicatechin gallate ameliorates cyprodinil‐induced cardiac developmental defects through inhibiting aryl hydrocarbon receptor in zebrafish

Induction of oxidative stress and cardiac developmental toxicity in zebrafish embryos by arsenate at environmentally relevant concentrations

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