Exposure to Diesel Exhaust Particles and Indoor Endotoxin During Early Childhood Increases the Risk for Persistent Wheeze at Age Three

Ryan, Pat; Bernstein, David I.; Levin, Linda; Burkle, Jeff; Villareal, Manuel; Kalra, H.; Lockey, James E.; Hershey, Gurjit K. Khurana; LeMasters, Grace K.

doi:10.1016/j.jaci.2007.12.262

Cited by 1 publication

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“…The central hypothesis of this study was that traffic-related particle exposure during early childhood increases the risk of persistent wheezing at age 3 years, and this effect is modified by exposure to indoor endotoxin. Some of these studies have previously been reported in the form of an abstract (29).…”

Section: What This Study Adds To the Fieldmentioning

confidence: 99%

Exposure to Traffic-related Particles and Endotoxin during Infancy Is Associated with Wheezing at Age 3 Years

Ryan¹,

Bernstein²,

Lockey³

et al. 2009

Am J Respir Crit Care Med

103

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Rationale: Murine models demonstrate a synergistic production of reactive oxygen species on coexposure to diesel exhaust particles and endotoxin. Objectives: It was hypothesized that coexposure to traffic-related particles and endotoxin would have an additive effect on persistent wheezing during early childhood. Methods: Persistent wheezing at age 36 months was assessed in the Cincinnati Childhood Allergy and Air Pollution Study, a high-risk birth cohort. A time-weighted average exposure to traffic-related particles was determined by applying a land-use regression model to the homes, day cares, and other locations where children spent time from birth through age 36 months. Indoor levels of endotoxin were measured from dust samples collected before age 12 months. The relationship between dichotomized (,/>75th percentile) trafficrelated particle and endotoxin exposure and persistent wheezing, controlling for potential covariates, was examined. Measurements and Main Results: Persistent wheezing at age 36 months was significantly associated with exposure to increased levels of traffic-related particles before age 12 months (OR 5 1.75; 95% confidence interval, 1.07-2.87). Coexposure to endotoxin had a synergistic effect with traffic exposure on persistent wheeze (OR 5 5.85; 95% confidence interval, 1.89-18.13) after adjustment for significant covariates. Conclusions:The association between traffic-related particle exposure and persistent wheezing at age 36 months is modified by exposure to endotoxin. This finding supports prior toxicological studies demonstrating a synergistic production of reactive oxygen species after coexposure to diesel exhaust particles and endotoxin. The effect of early versus later exposure to traffic-related particles, however, remains to be studied because of the high correlation between exposure throughout the first 3 years of life.

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Section: What This Study Adds To the Fieldmentioning

confidence: 99%