Exposure to DDT and hypertensive disorders of pregnancy among South African women from an indoor residual spraying region: The VHEMBE study

Murray, Jennifer; Eskenazi, Brenda; Bornman, Riana; Gaspar, Fraser W.; Crause, Madelein; Obida, Muvhulawa; Chevrier, Jonathan

doi:10.1016/j.envres.2017.12.006

Cited by 34 publications

(27 citation statements)

References 33 publications

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“…Briefly, the 28 investigations were published between 2006–2018 with sample sizes ranging from 58 to 1.21 million women. There were 6 studies on POP (Eslami et al 2016; Murray et al 2018; Savitz et al 2012; 2014; Stein et al 2009; Starling et al 2014), one study on water contaminants (Carwile et al 2014), 11 investigations on air pollutants (Dadvand et al 2014; Lee et al 2013; Madsen et al 2017; Mendola et al 2016; Nahidi et al 2014; Pedersen et al 2017; Savitz et al 2015; Wang et al 2018b; Wesselink et al 2017; Wu et al 2016; Yorifuji et al 2015), 6 examining metals (Elongi Moyene et al 2016; Maduray et al 2017; Sandoval-Carrillo et al 2016; Laine et al 2015; Wang et al 2018a; Vigeh et al 2006), and 4 investigations evaluating non-persistent organic pollutants (Cantonwine et al 2016; Leclerc et al 2014; Ye et al 2017; Shaw et al 2018).…”

Section: Resultsmentioning

confidence: 99%

Environmental contaminants and preeclampsia: a systematic literature review

Rosen

Muñoz

McElrath

et al. 2018

Journal of Toxicology and Environmental Health, Part B

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Preeclampsia is a medical condition specific to pregnancy characterized by high blood pressure and protein in the woman’s urine, indicating kidney damage. It is one of the most serious reproductive conditions, posing substantial risks to the baby and potentially fatal for the mother. The causes of preeclampsia are largely unknown and environmental contaminants merit further investigation. The aim of this review was to determine the association between environmental chemical exposures and preeclampsia.PubMed was searched for articles examining a priori chemical exposures and preeclampsia through April 2018. Studies were included in our review if they included at least 10 cases, evaluated preeclampsia independent of gestational hypertension, and used either measured or modeled exposure assessments.Our review contained 28 investigations examining persistent organic pollutants (POP) (6 studies), drinking water contaminants (1 study), atmospheric pollutants (11 studies), metals and metalloids (6 studies), and other environmental contaminants (4 studies). There were an insufficient number of investigations on most chemicals to draw definitive conclusions, but strong evidence existed for an association between preeclampsia and cadmium (Cd). There is suggestive evidence for associations between nitrogen dioxide (NO2), particulate matter (PM)2.5, and traffic exposure with preeclampsia.There is evidence for an association between preeclampsia and Cd but insufficient literature to evaluate many other environmental chemicals. Additional studies using repeated measures, appropriate biological matrices, and mixtures methods are needed to expand this area of research and address the limitations of previous studies.

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Section: Resultsmentioning

confidence: 99%

Environmental contaminants and preeclampsia: a systematic literature review

Rosen

Muñoz

McElrath

et al. 2018

Journal of Toxicology and Environmental Health, Part B

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“…Finally, we included 27 articles in this systematic review and out of 27 studies, 13 studies were included in the meta-analysis study (see Fig 1). The majority of the articles, 15 articles included in this review were cross-sectional [16,17,[22][23][24][25][26][27][28][29][30][31][32][33][34][35], nine were case-control [15,[36][37][38][39][40][41][42][43], and the remaining three were of a longitudinal study design [34,44,45]. Studies from ten countries were included in this review.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

“…In addition, seasonal variation [32,43] and exposure to insecticide chemicals used for malaria control [22] were identified as associated factors for developing HDP. However, this systematic review was not found sufficient evidence to draw strong to consider as associated factor for developing HDP.…”

Section: Plos Onementioning

confidence: 99%

Factors associated with hypertensive disorders of pregnancy in sub-Saharan Africa: A systematic and meta-analysis

et al. 2020

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Background Hypertensive disorders of pregnancy (HDP) are common complications of pregnancy globally, including sub-Saharan African (SSA) countries. Although it has a high burden of maternal and neonatal mortality and morbidity, evidence on the risk of the problem is limited. Therefore, the aim of this review was to systematically examine factors associated with HDP among women in SSA countries. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. Articles conducted in SSA and published in English from January 2000 to May 2020 from electronic databases including MEDLINE, EMBASE, PubMed, and CINAHL were included. Articles, which focused on HDP and found to be relevant through the reference check, were included. Additional articles found through a hand search of reference lists were also included. The quality of papers was appraised using the Critical Appraisal Skills Programme (CASP) scale. Two reviewers independently screened, extracted, and assessed the quality of the articles. STATA 16 software was used to compute the pooled estimated odds ratios for each of the identified associated factor. Both random and fixed effect models were used for analysis. Heterogeneity of the studies and small study bias were checked by I 2 and asymmetric test, respectively. Results Twenty-seven studies met the inclusion criteria and included in the systematic review and meta-analysis. Significant associations with HDP were identified through meta-analysis for the following variables: being primiparous (

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“…He reported that IRS was associated with elevated serum DDT/DDE and urinary pyrethroid metabolite concentrations in peripartum samples collected from 751 VHEMBE women 24,25 . Associations between maternal exposure to DDT and hypertensive disorders of pregnancy 26 , larger birth size 27 , and higher body composition measures, and marginally altered motor development were found among VHEMBE girls at age 1 and/or 2 years 28 . Prenatal exposure to pyrethroids was also associated with lower body composition measures among boys 28 and altered motor development among girls aged 1 to 3.5 years 29,30 .…”

Section: Nutrition and Toxicodietary Exposuresmentioning

confidence: 84%

Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop

et al. 2019

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Individuals with African ancestry have extensive genomic diversity but have been underrepresented in genomic research. There is also extensive global diversity in the exposome (the totality of human environmental exposures from conception onwards) which should be considered for integrative genomic and environmental health research in Africa. To address current research gaps, we organized a workshop on environmental health research in Africa in conjunction with the H3Africa Consortium and the African Society of Human Genetics meetings in Kigali, Rwanda. The workshop was open to all researchers with an interest in environmental health in Africa and involved presentations from experts within and outside of the Consortium. This workshop highlighted innovative research occurring on the African continent related to environmental health and the interplay between the environment and the human genome. Stories of success, challenges, and collaborative opportunities were discussed through presentations, breakout sessions, poster presentations, and a panel discussion. The workshop informed participants about environmental risk factors that can be incorporated into current or future epidemiology studies and addressed research design considerations, biospecimen collection and storage, biomarkers for measuring chemical exposures, laboratory strategies, and statistical methodologies. Inclusion of environmental exposure measurements with genomic data, including but not limited to H3Africa projects, can offer a strong platform for building gene-environment (G x E) research in Africa. Opportunities to leverage existing resources and add environmental exposure data for ongoing and planned studies were discussed. Future directions include expanding the measurement of both genomic and exposomic risk factors and incorporating sophisticated statistical approaches for analyzing high dimensional G x E data. A better understanding of how environmental and genomic factors interact with nutrition and infection is also needed. Considering that the environment represents many modifiable risk factors, these research findings can inform intervention and prevention efforts towards improving global health.

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Exposure to DDT and hypertensive disorders of pregnancy among South African women from an indoor residual spraying region: The VHEMBE study

Cited by 34 publications

References 33 publications

Environmental contaminants and preeclampsia: a systematic literature review

Environmental contaminants and preeclampsia: a systematic literature review

Factors associated with hypertensive disorders of pregnancy in sub-Saharan Africa: A systematic and meta-analysis

Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop

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