Exposure to Crude Oil Induces Retinal Apoptosis and Impairs Visual Function in Fish

Magnuson, Jason T.; Bautista, Naim M.; Lucero, JoAnn; Lund, Amie K.; Xu, Elvis Genbo; Schlenk, Daniel; Burggren, Warren W.; Roberts, Aaron P.

doi:10.1021/acs.est.9b07658

Cited by 58 publications

(33 citation statements)

References 52 publications

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“…In PFOA-exposed F0 larvae, rpe65a and atp6v0e1 were downregulated. Downregulation of rpe65a is associated with retinal degeneration in zebrafish [47], and loss of RPE65 function leads to blindness in humans [48]. Atp6v0e1 is involved in visual-motor behavior [49].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, human health research and policies are mainly concerned with the directly exposed subject. In the F0 generation, PFOA exposure was associated with hypoactivity, with a potential visual-motor impact occurring via the downregulation of vision-related genes rpe65a and atp6v0e1 [47,49]. Similarly, PFOS-exposed larvae were also hypoactive in the light and had a downregulated photoreceptor gene (kif3c) [61].…”

Section: Discussionmentioning

confidence: 99%

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Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)

Haimbaugh

Akemann

et al. 2022

Toxics

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Per- and polyfluoroalkyl substances (PFASs) are ubiquitous in the environment and are tied to myriad health effects. Despite the phasing out of the manufacturing of two types of PFASs (perfluorosulfonic acid (PFOS) and perfluorooctanoic acid (PFOA)), chemical composition renders them effectively indestructible by ambient environmental processes, where they thus remain in water. Exposure via water can affect both human and aquatic wildlife. PFASs easily cross the placenta, exposing the fetus at critical windows of development. Little is known about the effects of low-level exposure during this period; even less is known about the potential for multi- and transgenerational effects. We examined the effects of ultra-low, very low, and low-level PFAS exposure (7, 70, and 700 ng/L PFOA; 24, 240, 2400 ng/L PFOS; and stepwise mixtures) from 0–5 days post-fertilization (dpf) on larval zebrafish (Danio rerio) mortality, morphology, behavior and gene expression and fecundity in adult F0 and F1 fish. As expected, environmentally relevant PFAS levels did not affect survival. Morphological abnormalities were not observed until the F1 and F2 generations. Behavior was affected differentially by each chemical and generation. Gene expression was increasingly perturbed in each generation but consistently showed lipid pathway disruption across all generations. Dysregulation of behavior and gene expression is heritable, even in larvae with no direct or indirect exposure. This is the first report of the transgenerational effects of PFOA, PFOS, and their mixture in terms of zebrafish behavior and untargeted gene expression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)

Haimbaugh

Akemann

et al. 2022

Toxics

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“…Polycyclic aromatic hydrocarbons in crude oil have been reported to impair vision in fish. Magnuson et al ( 2020 ) found out that embryonic zebrafish ( Danio rerio ) exposed to crude oil exhibited cell death in the retina and bradycardia. A reduction in cardiovascular performance was observed in the Gulf killfish ( Fundulus grandis ) exposed to oil.…”

Section: Environmental Pollution As a Results Of Crude Oil Exploration And Processingmentioning

confidence: 99%

Crude oil exploration in Africa: socio-economic implications, environmental impacts, and mitigation strategies

et al. 2021

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Crude oil exploration is a source of significant revenue in Africa via trade and investment since its discovery in the mid-19th Century. Crude oil has bolstered the continent’s economy and improved the wellbeing of the citizenry. Historically, Africa has suffered from conflicts due to uneven redistribution of crude oil revenue and severe environmental pollution. Advancements in geophysical survey techniques, such as magnetic and gravity methods, to seismic methods, have made the commercial exploration of crude oil possible for some other countries in Africa apart from Nigeria, Angola, Algeria, Libya, and Egypt. The occurrence of organic-rich, oil-prone Type I, II, and mixed II/III kerogens in sedimentary basins and entrapment within reservoir rocks with intrinsic petrophysical properties are majorly responsible for the large deposits of hydrocarbon in Africa. The unethical practices by some multinational oil corporations have resulted in social movements against them by host communities and human rights groups. The unscrupulous diversion of public funds, award of oil blocks, and production rights to certain individuals have impaired economic growth in Africa. The over-dependence on crude oil revenues has caused the economic recession in oil-producing countries due to plummeting oil prices and global pandemic. Most host communities of crude oil deposits suffer from a lack of infrastructure, arable soils, clean water, and their functioning capabilities are violated by crude oil exploratory activities, without adequate compensations and remedial actions taken by oil companies and the government. Thus, this review examines crude oil exploration in Africa and provides insight into the environmental and socio-economic implications of crude oil exploration in Africa. Furthermore, this report highlights some recommendations that may ensure ethical and sustainable practices toward minimizing negative impacts and improving the quality of life in affected communities.

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“…Disruption of these pathways affected retinal histology as well as visual acuity (as determined by optomotor response) in a PAH dose-dependent manner in mahi-mahi (Xu et al 2018), red drum, and sheepshead minnows (Magnuson et al 2018). A subsequent study using slick oil and zebrafish determined that disruption of these gene expression pathways and visual acuity were consistent with a dose-dependent loss of glial cells supporting the neuronal network in the retina (Magnuson et al 2020). These data suggest that exposure to oil may disrupt eye development and function across a number of fish species.…”

Section: Fishmentioning

confidence: 91%

A review of the toxicology of oil in vertebrates: what we have learned following the Deepwater Horizon oil spill

Takeshita

Bursian

Colegrove

et al. 2021

Journal of Toxicology and Environmental Health, Part B

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In the wake of the Deepwater Horizon (DWH) oil spill, a number of government agencies, academic institutions, consultants, and nonprofit organizations conducted lab-and field-based research to understand the toxic effects of the oil. Lab testing was performed with a variety of fish, birds, turtles, and vertebrate cell lines (as well as invertebrates); field biologists conducted observations on fish, birds, turtles, and marine mammals; and epidemiologists carried out observational studies in humans. Eight years after the spill, scientists and resource managers held a workshop to summarize the similarities and differences in the effects of DWH oil on vertebrate taxa and to identify remaining gaps in our understanding of oil toxicity in wildlife and humans, building upon the cross-taxonomic synthesis initiated during the Natural Resource Damage Assessment. Across the studies, consistency was found in the types of toxic response observed in the different organisms. Impairment of stress responses and adrenal gland function, cardiotoxicity, immune system dysfunction, disruption of blood cells and their function, effects on locomotion, and oxidative damage were observed across taxa. This consistency suggests conservation in the mechanisms of action and disease pathogenesis. From a toxicological perspective, a logical progression of impacts was noted: from molecular and cellular effects that manifest as organ dysfunction, to systemic effects that compromise fitness, growth, reproductive potential, and survival. From a clinical perspective, adverse health effects from DWH oil spill exposure formed a suite of signs/symptomatic responses that at the highest doses/concentrations resulted in multi-organ system failure.

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Exposure to Crude Oil Induces Retinal Apoptosis and Impairs Visual Function in Fish

Cited by 58 publications

References 52 publications

Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)

Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)

Crude oil exploration in Africa: socio-economic implications, environmental impacts, and mitigation strategies

A review of the toxicology of oil in vertebrates: what we have learned following the Deepwater Horizon oil spill

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