Exposure to Coxiella burnetii and risk of non-Hodgkin lymphoma: a retrospective population-based analysis in the Netherlands

Roeden, Sonja E van; Houwelingen, F. Van; Donkers, Chiel M J; Hogewoning, Sander J; Lange, Marit M A de; Hoek, Wim van der; Kampschreur, Linda M.; Bonten, Marc J. M.; Hoepelman, Andy I. M.; Bleeker‐Rovers, Chantal P.; Wever, Peter C.; Oosterheert, Jan Jelrik

doi:10.1016/s2352-3026(18)30038-3

Cited by 16 publications

(17 citation statements)

References 25 publications

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“…Consequently, Q fever complication and unusual presentation of the diseases are probably underestimated. 21 , 22 , 23 In the Netherlands, the mortality rate varies from 1% in cases of acute Q fever to 13% in cases of persistent focalized C burnetii infection (9% for endocarditis and 21% for vascular infection). 22 , 24 To our knowledge, no study on aCL associated with Q fever has been published from the Netherlands.…”

Section: Discussionmentioning

confidence: 99%

“… 27 Placentitis and microthrombi have been described. 23 In children, Q fever has been marked by an age-related increase in incidence. 28 The imbalance in the sex ratio distribution of the disease occurred after puberty, and males were most affected by vascular infections and presented with a higher secretion of aCL antibodies during acute Q fever.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

et al. 2018

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Key Points Question What are the characteristics and clinical presentations of Coxiella burnetii infection using 21st-century–clarified definitions? Finding In a cohort study of 2434 patients with Q fever, the following new critical Q fever foci were identified: acute endocarditis, lymphadenitis, and bone marrow involvement in hemophagocytic syndrome. Lymphadenitis is a risk factor for lymphoma, and the elevation of IgG anticardiolipin antibody titers in acute Q fever is associated with complications. Meaning Screening for anticardiolipin antibodies may help prevent acute Q fever complications; the use of transthoracic echocardiography in acute Q fever and positron emission tomographic scanning in suspected persistent focalized infection is justified to improve the care of patients with Q fever.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

et al. 2018

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“…burnetii infection, known as Q fever, has been reported in domestic and wild animals, birds, and in a wide variety of tick species [11,19]. Moreover, C. burnetii infection is globally a major public health problem with infections being reported sporadically, as outbreaks or endemic disease [6,[19][20][21]. However, little is known about C. burnetii in many resourcelimited countries and this is also true for Africa, where limited diagnostic resources are resulting in a significant underestimation of the disease [22], although some studies have clearly demonstrated the importance of Q fever [23,24].…”

Section: Discussionmentioning

confidence: 99%

High Prevalence and New Genotype of Coxiella burnetii in Ticks Infesting Camels in Somalia

et al. 2021

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Coxiella burnetii is the causative agent of Q fever. It can infect animals, humans, and birds, as well as ticks, and it has a worldwide geographical distribution. To better understand the epidemiology of C. burnetii in Somalia, ticks infesting camels were collected from five different regions, including Bari, Nugaal, Mudug, Sool, and Sanaag, between January and March 2018. Collected ticks were tested for C. burnetii and Coxiella-like endosymbiont DNA by using IS1111, icd, and Com1-target PCR assays. Moreover, sequencing of the 16S-rRNA was conducted. Molecular characterization and typing were done by adaA-gene analysis and plasmid-type identification. Further typing was carried out by 14-marker Multi-Locus Variable-Number Tandem Repeats (MLVA/VNTR) analysis. The investigated ticks (n = 237) were identified as Hyalomma spp. (n = 227, 95.8%), Amblyomma spp. (n = 8, 3.4%), and Ripicephalus spp. (n = 2, 0.8%), and 59.1% (140/237) of them were positive for Coxiella spp. While Sanger sequencing and plasmid-type identification revealed a C. burnetii that harbours the QpRS-plasmid, MLVA/VNTR genotyping showed a new genotype which was initially named D21. In conclusion, this is the first report of C. burnetii in ticks in Somalia. The findings denote the possibility that C. burnetii is endemic in Somalia. Further epidemiological studies investigating samples from humans, animals, and ticks within the context of “One Health” are warranted.

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“…The list of bacterial pathogens involved in lymphogenesis has also recently included C. burnetii , the Gram-negative intracellular pathogen responsible for Q fever [ 118 ]. The role of this bacterium in the development of DLBCL and other NHL lymphomas was first reported in 2016, when C. burnetii lymphadenitis and hemophogocytic syndrome was linked to NHL lymphomas, such as DLBCL, MALT-lymphoma, FL, Mantle cell lymphoma and chronic lymphocytic leukemia [ 14 ].…”

Section: Coxiella Burnetii ( C Burnetii ) and Various Nhlmentioning

confidence: 99%

“…The role of C. burnetii in the pathogenesis of NHL is not fully understood. C. burnetii DNA was present in about 36% of cases with NHL vs. 8% of controls but this difference was not statistically significant [ 118 ]. It has been speculated that the risk of NHL could be increased after exposure to C. burnetii .…”

Section: Coxiella Burnetii ( C Burnetii ) and Various Nhlmentioning

confidence: 99%

Bacterial Infection and Non-Hodgkin B-Cell Lymphoma: Interactions between Pathogen, Host and the Tumor Environment

Biernat

Wróbel

2021

IJMS

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Non-Hodgkin B-cell lymphomas (NHL) are a heterogeneous group of lymphoid neoplasms with complex etiopathology, rich symptomatology, and a variety of clinical courses, therefore requiring different therapeutic approaches. The hypothesis that an infectious agent may initiate chronic inflammation and facilitate B lymphocyte transformation and lymphogenesis has been raised in recent years. Viruses, like EBV, HTLV-1, HIV, HCV and parasites, like Plasmodium falciparum, have been linked to the development of lymphomas. The association of chronic Helicobacter pylori (H. pylori) infection with mucosa-associated lymphoid tissue (MALT) lymphoma, Borrelia burgdorferi with cutaneous MALT lymphoma and Chlamydophila psittaci with ocular adnexal MALT lymphoma is well documented. Recent studies have indicated that other infectious agents may also be relevant in B-cell lymphogenesis such as Coxiella burnettii, Campylobacter jejuni, Achromobacter xylosoxidans, and Escherichia coli. The aim of the present review is to provide a summary of the current literature on infectious bacterial agents associated with B-cell NHL and to discuss its role in lymphogenesis, taking into account the interaction between infectious agents, host factors, and the tumor environment.

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Exposure to Coxiella burnetii and risk of non-Hodgkin lymphoma: a retrospective population-based analysis in the Netherlands

Cited by 16 publications

References 25 publications

Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

High Prevalence and New Genotype of Coxiella burnetii in Ticks Infesting Camels in Somalia

Bacterial Infection and Non-Hodgkin B-Cell Lymphoma: Interactions between Pathogen, Host and the Tumor Environment

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