Exposure to Chinese famine in early life modifies the association between hyperglycaemia and cardiovascular disease

Zhang, Yuxia; Ying, Yaoyu; Zhou, Liang; Fu, Jiaojiao; Shen, Yueping; Ke, Chaofu

doi:10.1016/j.numecd.2019.07.004

Cited by 16 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, neither method addresses the question of whether fetal famine exposure increased the risk of earlyonset (at 18-45 years of age) T2DM. A study published in 2019 found that early-life exposure to famine exacerbated the association between hyperglycaemia and cardiovascular disease 3 , which suggests that famine exposure might increase the risk of early-onset T2DM.…”

mentioning

confidence: 99%

Chinese Famine and the diabetes mellitus epidemic

et al. 2019

View full text Add to dashboard Cite

mentioning

confidence: 99%

Chinese Famine and the diabetes mellitus epidemic

et al. 2019

View full text Add to dashboard Cite

“…The first research report of long-term influence of CGF in fetal origins on cardiovascular systems was our study several years ago (24). Since then, a number of studies reported that CGF has a close link to increase incidence of cardiovascular and metabolic diseases (25)(26)(27)(28). However, it is noted that CGF affected whole country and population 50 years ago, but the possibility is small to have unexposed subjects as the control with the same ages born during 1959-1961.…”

Section: Discussionmentioning

confidence: 95%

Sex Differences at Early Old Stage in Glycolipid Metabolism and Fatty Liver in Offspring Prenatally Exposed to Chinese Great Famine

Zhang

Ding

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

BackgroundAbout 50 years ago, Chinese Great Famine (CGF) affected the entire population in China, and its long-term influence on the offspring has attracted significant attention for research. However, information on possible metabolic differences between sexes is limited. This study explored whether there might be sex differences in the risks of development of glucolipid metabolic dysfunction and fatty liver following prenatal exposure to CGF.Materials and MethodsThere were 11,417 subjects around 55 years of age (6,661 women and 4,756 men). They were divided as the exposed group in which the fetal stage was in CGF, and the unexposed group included those born after CGF. Analysis focused on comparisons between sexes.ResultsCompared to the unexposed group, the BMI and triglyceride (P < 0.05) in men were higher in exposed group, while waist circumference and blood sugar (P < 0.05) in the exposed women were significantly higher. With the ages being properly balanced, the risks of glycolipid metabolic dysfunction were significantly higher in both men and women in the exposed than in the unexposed group (P < 0.001). Prenatal exposure to CGF significantly increased risks of abnormal BMI (P < 0.001, 95% CI: 2.305–2.93), blood sugar (P < 0.05, 95% CI: 1.050–1.401), triglycerides (P < 0.05, 95% CI: 1.006–1.245), and fatty liver (P < 0.001, 95% CI: 1.121–1.390) in men, and increased risks of abnormal blood sugar (P < 0.05, 95% CI: 1.024–1.689) and positive urine sugar (P < 0.05, 95% CI: 1.062–6.211) in women. Height and body weight were either the same or higher in the exposed subjects compared with the unexposed ones, regardless of sexes.ConclusionThis study is the first to identify sex differences in the long-term effects of CGF on metabolism and fatty liver. Importance of the findings include the benefits of prescribing medicine for the early prevention of certain diseases for each sex before aging based on the differences revealed. This study also shows “catch-up growth” in the offspring prenatally exposed to CGF as possible mechanisms underlying the long-term effects.

show abstract

“…This might be caused by early life exposure to serious adverse condition especially malnutrition during the Japanese military occupation (1937)(1938)(1939)(1940)(1941)(1942)(1943)(1944)(1945) and the Chinese Famine (1958)(1959)(1960)(1961), respectively. Exposures to adverse living condition and malnutrition in early life are often associated with metabolic syndrome including hyperglycemia, hypertension, and type 2 diabetes that contribute to an increased occurrence of CVD in later life [55][56][57][58]. Thus, to decrease adverse events including malnutrition in early life should be important for the prevention of the major types of CVD in later life.…”

Section: Discussionmentioning

confidence: 99%

Associations of socioeconomic factors with cause-specific Mortality and burden of cardiovascular diseases: findings from the vital registration in urban Shanghai, China, during 1974–2015

Zhang

Han

et al. 2020

BMC Public Health

View full text Add to dashboard Cite

Background: Cardiovascular disease (CVD) is the leading cause of mortality worldwide. The effect of socioeconomic factors on cause-specific mortality and burden of CVD is rarely evaluated in low-and middleincome countries, especially in a rapidly changing society. Methods: Original data were derived from the vital registration system in Yangpu, a representative, populationstable district of urban Shanghai, China, during 1974-2015. Temporal trends for the mortality rates and burden of CVD during 1974-2015 were evaluated using Joinpoint Regression Software. The burden was evaluated using agestandardized person years of life loss per 100,000 persons (SPYLLs). Age-sex-specific CVD mortality rates were predicted by using age-period-cohort Poisson regression model.

show abstract

Exposure to Chinese famine in early life modifies the association between hyperglycaemia and cardiovascular disease

Cited by 16 publications

References 31 publications

Chinese Famine and the diabetes mellitus epidemic

Chinese Famine and the diabetes mellitus epidemic

Sex Differences at Early Old Stage in Glycolipid Metabolism and Fatty Liver in Offspring Prenatally Exposed to Chinese Great Famine

Associations of socioeconomic factors with cause-specific Mortality and burden of cardiovascular diseases: findings from the vital registration in urban Shanghai, China, during 1974–2015

Contact Info

Product

Resources

About