Exposure to cannabinoid receptor 1 ligands induces miswiring of GnRH axons in the brain of zebrafish embryos

Bovolin, Patrizia; D’Atri, Ilaria; Cottone, Erika; Pomatto, Valentina; Zuccarini, Giulia; Gothilf, Yoav; Merlo, Giorgio R.

doi:10.1016/j.reprotox.2017.06.144

Cited by 1 publication

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“…In another study, it was found that THC leads to a 65% reduction in testosterone levels, which lasted for an hour. Therefore, it was concluded that the consequences of chronic exposure are less severe compared to acute administration and can be related to the development of resistance against other drugs ( Bovolin et al, 2017 , Sharma and Balhara, 2018 ). In experiments conducted on different animals for the study, the effect of acute dose of cannabinoids showed an increase in ACTH and GC levels with respect to the dose of cannabinoids and showed a similar effect as perceived by the increase in the CRH level ( Franks et al, 2020 ).…”

Section: Marijuana and Health Effects: Conflicting But Interesting Outcomesmentioning

confidence: 99%

Wonder or evil?: Multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals

Datta

Ramamurthy

Anand

et al. 2021

Saudi Journal of Biological Sciences

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Cannabis sativa , widely known as ‘Marijuana’ poses a dilemma for being a blend of both good and bad medicinal effects. The historical use of Cannabis for both medicinal and recreational purposes suggests it to be a friendly plant. However, whether the misuse of Cannabis and the cannabinoids derived from it can hamper normal body physiology is a focus of ongoing research. On the one hand, there is enough evidence to suggest that misuse of marijuana can cause deleterious effects on various organs like the lungs, immune system, cardiovascular system, etc. and also influence fertility and cause teratogenic effects. However, on the other hand, marijuana has been found to offer a magical cure for anorexia, chronic pain, muscle spasticity, nausea, and disturbed sleep. Indeed, most recently, the United Nations has given its verdict in favour of Cannabis declaring it as a non-dangerous narcotic. This review provides insights into the various health effects of Cannabis and its specialized metabolites and indicates how wise steps can be taken to promote good use and prevent misuse of the metabolites derived from this plant.

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Section: Marijuana and Health Effects: Conflicting But Interesting Outcomesmentioning

confidence: 99%

Wonder or evil?: Multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals

Datta

Ramamurthy

Anand

et al. 2021

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

show abstract

Exposure to cannabinoid receptor 1 ligands induces miswiring of GnRH axons in the brain of zebrafish embryos

Cited by 1 publication

References 2 publications

Wonder or evil?: Multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals

Wonder or evil?: Multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals

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